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Bird (Avian) Polyclonal DBH Primary Antibody for IEM, ICC - ABIN617902
von Bartheld, Bothwell: Development and distribution of noradrenergic and cholinergic neurons and their trophic phenotypes in the avian ceruleus complex and midbrain tegmentum. in The Journal of comparative neurology 1992
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Human Polyclonal DBH Primary Antibody for WB - ABIN550216
Sabban, Kvetnanský: Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. in Trends in neurosciences 2001
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Human Polyclonal DBH Primary Antibody for WB - ABIN550217
Kish, Kalasinsky, Derkach, Schmunk, Guttman, Ang, Adams, Furukawa, Haycock: Striatal dopaminergic and serotonergic markers in human heroin users. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001
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Human Polyclonal DBH Primary Antibody for ICC, IF - ABIN4305916
Scifo, Szwajda, Soliymani, Pezzini, Bianchi, Dapkunas, Dębski, Uusi-Rauva, Dadlez, Gingras, Tyynelä, Simonati, Jalanko, Baumann, Lalowski: Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. in Journal of proteomics 2015
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Human Polyclonal DBH Primary Antibody for WB - ABIN152461
Li, Ham, Ma, Kuo, Kanter, Kim, Ko, Quan, Sardi, Li, Arancio, Kang, Sulzer, Tang: Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. in Autophagy 2019
Human Polyclonal DBH Primary Antibody for IF, IHC (p) - ABIN655173
Fernàndez-Castillo, Ribasés, Roncero, Casas, Gonzalvo, Cormand: Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. in Psychiatric genetics 2010
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While octopamine (OA) release reduced body fat, we inferred that tyramine (TA)release has the opposite effect, rescuing the fat deposition phenotype clearly seen in Tbh-deficient Drosophila.
Interdomain long-range electron transfer becomes rate-limiting in the Y216A variant of tyramine beta-monooxygenase.
Data show that ovulation is defective in females lacking tyramine beta-hydroxylase, resulting in blockage of mature oocytes within the ovaries.
Recombinant tyramine beta-monooxygenase requires copper for activity and has a typical type 2 copper electron spin resonance (EPR) spectrum.
Octopamine is not the natural signal for flight initiation because flies lacking octopamine [tyramine-beta-hydroxylase null mutants] can fly, though they show markedly different flight-initiation and -maintenance capabilities compared to wild-type flies.
the tyramine beta-monooxygenase mechanism is different from that of the mammalian enzyme, dopamine beta-monooxygenase
DBH-containing neurons express both ATP7A and ATP7B. The two transporters are located in distinct cellular compartments and oppositely regulate the export of soluble DBH from cultured neuronal cells under resting conditions.
Data show the wake lengths of locus coeruleus (LC)-specific dopamine beta hydroxylase (dbh)-mutated mice were decreased.
In mice, hepatic Dbh mRNA levels correlated with cardiovascular risk phenotypes.
Dbh-deficient mice exhibit shorter latencies to loss of righting reflex and longer durations of hypersensitivity to general anesthesia.
our results suggest that DBH knockout mice have normal levels of dopamine 2 receptors in the high-affinity state and that additional mechanisms contribute to their behavioral sensitivity to psychostimulants
These results strongly suggest that the norepinephrine defect in Mecp2(-/Y) mice is likely to result from deficient expression of not only tyrosine hydroxylase but also DBH without significant loss of catecholaminergic neurons in the locus coeruleus.
Dbh-/- animals were hypersensitive to the behavioral effects of amphetamine.
A mutation in the ATP7B copper transporter causes reduced levels of this enzyme and norepinephrine in the mouse adrenal gland.
The response of mice deficient in this gene to cholecystokinin-8 induced satiety
Data show how deficiency of dopamine-beta-hydroxylase (DBH) and CRH affects tyrosine hydroxylase, DBH, and phenylethanolamine N-methyltransferase gene expression and protein levels in the adrenal medulla and stellate ganglia of control and stressed mice.
This meta-analysis suggests that the DBH rs1611115 genetic polymorphism might not be associated with Parkinson's disease.
Most DBH polymorphisms from the currently available loci showed no linkage to Alzheimer's disease, Parkinson's disease, and schizophrenia, indicating the lower possibility of these loci serving as genetic markers of the risks of diseases with neurodegenerative characteristics. On the other hand, the DBH rs2283123 and rs2007153 polymorphisms could have opposite effects on schizophrenia development in Caucasians
The findings of this study confirmed a strong association between genotype at rs1611115 and pDbetaH activity in Chinese patients with schizophrenia. Our data also suggest the rs1108580 polymorphism may influence some aspects of cognitive function in schizophrenia.
Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults
This study demonstrate the genetic influence of a family history of alcohol use disorders and DAT and DBH gene polymorphisms on the risk of withdrawal seizures and delirium tremens.
Homospecific activity computed for the WT of DBH and variant proteins showed a marginal decrease in A318S, W544S and R549C variants
This study indicated that DBH5'-Ins/Del polymorphism may not play a role in the susceptibility to tardive dyskinesia and cognitive deficits in schizophrenia with tardive dyskinesia.
DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.
Results suggest that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype.
Dopamine beta-Hydroxylase Deficiency is associated with Hyperinsulinemia and Insulin Resistance.
Dopamin Beta Hydroxylase gene +1603C > T polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population.
The genotype and allele distribution frequencies in rs1611115 were different between Parkinson's disease patients and the healthy control. The TT genotype may lead to a 2.95 times higher risk of Parkinson's disease occurrence compared with the common genotype CC. DBH rs1611115 polymorphism was likely to be associated with the susceptibility to PD, but we did not find that rs732833 is a susceptibility marker
Results suggest that the DBH gene may play an important role in the occurrence of schizophrenia (SCZ). Also, rs1611114 may be associated with SCZ susceptibility and related clinical symptoms in the Chinese Zhuang but not Han Chinese population.
Study found that the functional T allele in DBH SNP rs1611115, which reduces the conversion of dopamine to norepinephrine, corresponds with different BOLD-signal changes in responses to gambling, drug or sad cues in individuals with and without pathological gambling
This study demonstrated that the association between DbetaH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
We report the crystal structure of human dopamine b-hydroxylase, which is the enzyme converting dopamine to norepinephrine. The structure of the DOMON (dopamine b-monooxygenase N-terminal) domain, also found in 1600 other proteins, reveals a possible metal-binding site and a ligand-binding pocket
The p.Val26Met variant in the dopamine beta-hydroxylase gene at 9q34.2 was associated with Lung Cancer.
A DBH gene variant, rs129882, which confers risk to attention deficit hyperactivity disorder, is also associated with reduced in vitro gene expression.
No significant association was found between the DbetaH 5'-Ins/Del polymorphism and patients with chronic schizophrenia.
This study finding significant excess of rare nonsynonymous variants exclusive to European Americans smokers in DBH.
The present study presents evidence for the conclusion that the catalytic activity of dopamine beta-hydroxylase (DBH; dopamine beta-mono-oxygenase, EC 22.214.171.124) is regulated independently by pH and by anions
dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase
The dopamine beta-hydroxylase (DBH) gene maps to chromosome 1q2.13. Polymorphisms within the DBH gene are associated with piglet survivability.
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
, dopamine beta hydroxylase
, tyramine beta hydroxylase
, tyramine beta-hydroxylase
, tyramine beta-monooxygenase
, tyroside beta-hydroxylase
, dopamine beta-hydroxylase (dopamine beta-monooxygenase)
, dopamine beta-hydroxylase-like
, dopamine beta-monooxygenase
, Dopamine beta hydroxylase (dopamine beta-monooxygenase)