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anti-Human LGALS1 Antibodies:
anti-Rat (Rattus) LGALS1 Antibodies:
anti-Mouse (Murine) LGALS1 Antibodies:
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Mouse (Murine) Polyclonal LGALS1 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4899423
Silva-Monteiro, Reis Lorenzato, Kenji Nihei, Junqueira, Rabinovich, Hsu, Liu, Savino, Chammas, Villa-Verde: Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection. in The American journal of pathology 2007
Show all 10 Pubmed References
Human Polyclonal LGALS1 Primary Antibody for CyTOF, FACS - ABIN4899422
Yazawa, Geddes-Sweeney, Cedeno-Laurent, Walley, Barthel, Opperman, Liang, Lin, Schatton, Laga, Mihm, Qureshi, Widlund, Murphy, Dimitroff: Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. in The Journal of investigative dermatology 2015
Show all 8 Pubmed References
Human Monoclonal LGALS1 Primary Antibody for IF, IP - ABIN561662
Tan, Tan, Lin, Lim, Hew, Chung: Quantitative and temporal proteome analysis of butyrate-treated colorectal cancer cells. in Molecular & cellular proteomics : MCP 2008
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Human Polyclonal LGALS1 Primary Antibody for IHC, IHC (p) - ABIN4313208
Ek, Andréasson, Hober, Kampf, Pontén, Uhlén, Merz, Borrebaeck: From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. in Molecular & cellular proteomics : MCP 2006
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Human Polyclonal LGALS1 Primary Antibody for IF, WB - ABIN517485
Doe, Wuebbles, Allred, Rooney, Elorza, Burkin: Transgenic overexpression of the ?7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A. in Journal of cell science 2011
Human Polyclonal LGALS1 Primary Antibody for IF (p), IHC (p) - ABIN718586
Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015
Human Polyclonal LGALS1 Primary Antibody for IF, IHC (p) - ABIN2473743
Resnick: Should the "worst case scenario" be universal for chloramines? in Nephrology news & issues 1990
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Human Polyclonal LGALS1 Primary Antibody for ELISA, WB - ABIN2473744
Camby, Le Mercier, Lefranc, Kiss: Galectin-1: a small protein with major functions. in Glycobiology 2006
Show all 2 Pubmed References
Human Monoclonal LGALS1 Primary Antibody for ELISA, FACS - ABIN5582500
Couraud, Casentini-Borocz, Bringman, Griffith, McGrogan, Nedwin: Molecular cloning, characterization, and expression of a human 14-kDa lectin. in The Journal of biological chemistry 1989
High LGALS1 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer.
Pancreatic stellate cells promote cancer proliferation, migration, and invasion via Gal1-driven pathways. Gene-expression analyses of pancreatic tumor cells exposed to Gal1 reveal modulation of multiple regulatory pathways involved in tumor progression.
Studies indicate tumor-derived galectin-1, galectin-3 (show LGALS3 Antibodies) and galectin-9 (show LGALS9 Antibodies) in various cancers and anticancer therapies that target these molecules [Review].
The expression level of galectin-1 affects survival in patients with glioblastoma multiforme treated with adjuvant radiotherapy
Results show that Galectin-1 teams up with Galectin-3 (show LGALS3 Antibodies) to induce inflammatory/pro-degradative gene signature in human chondrocytes affecting the progression of osteoarthritis. Also, Galectin-3 (show LGALS3 Antibodies) was found to induce a pro-degradative-inflammatory gene signature in human chondrocytes, teaming up with Galectin-1 in the pathogenesis of osteoarthritis.
We also found a subset of prostate cancer patient-derived xenografts and prostate cancer patient samples with mild HO-1 (show HMOX1 Antibodies) and low Gal-1 expression levels. These results highlight a novel function of a human-used drug as a means of boosting the antitumor response
Gal-1, Gal-3 (show LGALS3 Antibodies) and Gal-9 (show LGALS9 Antibodies) galectin expression was higher in the myenteric plexus ganglia of chagasic patients
Results have shown that Gal-1 in the farnesyl-bound form acquires the ability to form self-clusters, and the galactoside-binding pocket of Gal-1 in the FTS (show AKTIP Antibodies)-bound form plays an important role in self-cluster formation.
Our findings support the introduction of galectin-1 as a reliable diagnostic marker for thyroid carcinomas. Its involvement in cell proliferation, migration, invasion and tumor growth also intimate functional involvement of galectin-1 in the progression of thyroid carcinoma, suggesting its potential as a therapeutic target
This study showed that obese children had significantly higher galectin-1 levels in proportion to fat mass in obese cases than those in healthy children, which may be interpreted as a compensatory increase in an attempt to improve glucose metabolism.
Gal-1 may serve as an adhesion molecule (show NCAM1 Antibodies) to interact with both cells and laminins
Gal-1 is expressed in a wide range of porcine tissues, including striated (show NSDHL Antibodies) muscle, liver, lung, brain, kidney, spleen, and intestine
LGALS1 was found widely expressed in all tissues and transient transfection indicated that galectin-1 locates both in cytoplasm and nucleus.
Data suggest that galectin-1 and VEGFR-2 (show KDR Antibodies) are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 (show KDR Antibodies) in luteal cells.
The relative abundance of PIBF (show PIBF1 Antibodies), LGALS1, LGALS3 (show LGALS2 Antibodies), LGALS3BP (show LGALS3BP Antibodies), and LGALS9 (show LGALS9 Antibodies) mRNA would display a differential expression pattern in the endometrium.
The binding affinity and specificity of galectin-1 for eight different beta-galactosyl terminal disaccharides was studied using molecular-dynamics simulations.
Overexpression of galectin-1 inhibited the proliferation of T-cells by means of HSC (show FUT1 Antibodies) activation, which reduced the inflammatory response by exerting immunosuppressive effects and furthermore enhanced immune tolerance and alleviated hepatic fibrosis in liver transplantation.
Gal-1 is a major driver of pancreatic cancer progression. Genetic deletion of Gal1 in a Kras-driven mouse model of pancreatic ductal adenocarcinoma results in a significant increase in survival through mechanisms involving decreased stroma activation, attenuated vascularization, and enhanced T cell infiltration leading to diminished metastasis rates.
This work identified Gal1, an endogenous immune regulatory lectin, as an integral component of the secretory granule machinery and unveil the unexpected function of this lectin in regulating CTL killing activity.
The results of this study showed that development of spinal axons as well as the locomotor abilities observed in adult mice are independent of Gal-1.
GAL-1 also enhanced the generation of neural crest cells from explanted neural tubes
this present study indicated that Gal-1 secreted from MSCs upregulated expression of Gal-1 and stimulated formation of tolerance immunophenotype on DCs, where the underlying mechanism was the regulation of the MAPK (show MAPK1 Antibodies) signaling pathway in DCs, thereby inhibiting the function of DCs
markedly increased brain Gal-1 and S-nitrosylated Gal-1 both in scrapie-infected rodents and human prion (show PRNP Antibodies) diseases.
Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil apoptosis.
Gal1 protein is essential for efficient liver regeneration following partial hepatectomy through the regulation of liver inflammation, hepatic cell proliferation, and the control of lipid storage in the regenerating liver.
findings show that galectin-1 (Gal-1), an immunoregulatory lectin widely expressed in mucosal tissues, contributes to Y. enterocolitica pathogenicity by undermining protective antibacterial responses.
Equine bone marrow mesenchymal stromal cells constitutively express high levels of galectin-1 mRNA relative to other articular cell types, suggesting a possible mechanism for their intra-articular immunomodulatory properties.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation.
14 kDa laminin-binding protein
, 14 kDa lectin
, S-Lac lectin 1
, beta-galactoside-binding lectin L-14-I
, beta-galactoside-binding protein 14kDa
, galectin 1
, lactose-binding lectin 1
, putative MAPK-activating protein PM12
, lectin galactoside-binding soluble 1
, beta-galactoside-binding lectin
, RL 14.5
, lectin, galactose binding, soluble 1
, lectin, galactoside-binding, soluble, 1 (galectin 1)
, 14K beta-galactoside-binding lectin
, galectin CG-1B
, lectin, galactoside-binding, soluble, 1
, beta-galactoside binding protein
, Beta-galactoside-binding lectin L-14-I
, Lactose-binding lectin 1
, Lectin galactoside-binding soluble 1