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ChREBP and FGF21 constitute a signaling (show FGF21 Proteins) axis likely conserved in humans that mediates an essential adaptive response to fructose ingestion that may participate in the pathogenesis of NAFLD and liver fibrosis.
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (show GCKR Proteins) (rs780094), GCKR (show GCKR Proteins) (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population.
Data (including data from studies using tissues/cells from transgenic mice) suggest that ChREBPalpha up-regulates expression and activity of NRF2 (show GABPA Proteins), initiating mitochondrial biogenesis in beta-cells; induction of NRF2 (show GABPA Proteins) is required for ChREBPalpha-mediated effects and for glucose-stimulated beta-cell proliferation. [NRF2 (show GABPA Proteins) = nuclear factor (erythroid-derived 2)-like 2 (show NFE2L2 Proteins) protein]
ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease.
A nutrient-sensitive mTOR (show FRAP1 Proteins)/ChREBP regulated transcriptional network could be a novel target to improve beta cell survival and glucose homeostasis in diabetes.
these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin (show INS Proteins) resistance.
results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP methylation and DNMT1 (show DNMT1 Proteins) variants could probably influence LDL-C to further modify ChREBP DNA methylation (show HELLS Proteins)
p = 6.69 x 10(-9) ] on chr7 at the carbohydrate-responsive element-binding protein-encoding (MLXIPL) gene locus displayed significant protective characteristics, while another variant rs6982502 [0.76 (0.68-0.84); p = 5.31 x 10(-7) ] on chr8 showed similar but weaker properties.
ChREBP role in non-alcoholic fatty liver disease.The involvement of ChREBP in FASN (show FASN Proteins) promoter histone modification.
This cross-sectional study suggests that MLXIPL rs3812316 genotypes may be associated with Triglyceride levels. there were significantly different genotype distributions in two TG categories: (1) subjects with normal TG values had a significantly higher G allele frequency than those with elevated TG levels
ChREBP and SHP (show LAMC1 Proteins) control the regulation of hepatic microsomal triglyceride transfer protein (show MTTP Proteins) expression and VLDL Secretion. Adenoviral Overexpression of ChREBP and SHP (show LAMC1 Proteins) Respectively Increased and Decreased Mttp (show MTTP Proteins) Expression.
The acute increase in circulating FGF21 (show FGF21 Proteins) following fructose gavage was absent in ChREBP knockout mice. Induction of ChREBP-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 (show FGF21 Proteins) knockout mice fed high-fructose diets.
Data, including data from studies in knockout mice, suggest that ChREBP is involved in coordinate regulation of sucrose and fructose absorption/metabolism by modulating gene expression in intestinal mucosa and liver.
Authors have identified a previously unappreciated negative feedback loop by which glucose-induced ChREBP-beta downregulates ChREBP-alpha-signaling providing new insight into the physiological role of islet ChREBP-beta and into the regulation of glucose-induced gene expression.
loss of adipose-ChREBP is sufficient to cause insulin (show INS Proteins) resistance potentially by regulating AT glucose transport.
Glucose-challenged Chrebp-/- mice exhibit a marked reduction in FGF21 (show FGF21 Proteins) production.
Study identify O-GlcNAcylation on Ser514 in the C-terminus of ChREBP and validate two important sites, Thr517 and Ser839 for O-GlcNAcylation and their function. Ser514 phosphorylation enhances ChREBP O-GlcNAcylation, maintaining the transcriptional activity of ChREBP; Ser839 O-GlcNAcylation is essential for its heterodimerization, DNA-binding activity, and nuclear export.
Data suggest that triiodothyronine and high glucose signal coordinately to up-regulate ChREBP, Ucp1 (show UCP1 Proteins), Glut4 (show SLC2A4 Proteins), and Fasn (show FASN Proteins) in brown adipocytes; ChREBP plays role as a central regulator of brown adipocyte activity/energy metabolism. (ChREBP = carbohydrate-responsive element-binding protein; Ucp1 (show UCP1 Proteins) = uncoupling protein-1 (show UCP1 Proteins); Glut4 (show SLC2A4 Proteins) = facilitated glucose transporter (show SLC2A12 Proteins)-4; Fasn (show FASN Proteins) = fatty acid synthase (show FASN Proteins), type-I)
findings suggest that a previously unknown link exists between ChREBP and the regulation of cholesterol synthesis that affects liver injury.
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
MLX interacting protein-like
, carbohydrate response element binding protein variant 1
, carbohydrate response element binding protein variant 2
, Williams-Beuren syndrome chromosomal region 14 protein homolog
, carbohydrate responsive element binding protein
, williams-Beuren syndrome chromosomal region 14 protein homolog
, MLX-interacting protein-like
, Mlx interactor
, WS basic-helix-loop-helix leucine zipper protein
, Williams Beuren syndrome chromosome region 14
, Williams-Beuren syndrome chromosome region 14 protein 1
, Williams-Beuren syndrome chromosome region 14 protein 2
, carbohydrate response element binding protein
, carbohydrate-responsive element-binding protein
, class D basic helix-loop-helix protein 14
, williams-Beuren syndrome chromosomal region 14 protein
, MLX interacting protein-like beta
, MLX interactor
, Williams-Beuren syndrome chromosome region 14 homolog
, putative hepatic transcription factor
, WBSCR14 protein-like
, Williams-Beuren syndrome chromosomal region 14 protein