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Study did not show any associations between rs2516839 and rs3737787 polymorphisms of the USF-1 gene and pediatric ischemic stroke. However, found an influence of specific genotypes on the outcome of stroke, including epilepsy, dysarthria, and a decrease in intellectual functioning.
our study first demonstrated that USF1 could activate the transcription of MUC13, thereby enhancing the proliferation and self-renewal of glioblastoma stem cells
miR-483 is a self-regulating microRNA and can activate its own expression via USF1
Findings suggest the underlying mechanism of upstream transcription factor 1 (USF1) in papillary thyroid cancer (PTC) development.
SNP (single-nucleotide polymorphism) alleles that reduced USF1 mRNA expression also displayed a beneficial cardiometabolic profile, featuring improved insulin sensitivity, a favorable lipid profile, and reduced atherosclerosis
USF1 gene can take part in basal transcription regulation of the human A3G gene in hepatocyte, and the identified E-box represented a binding site for the USF1.
A trend of increasing triglycerides levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was found.
Rta autoregulates BRLF1 transcription via its interaction with USF1 on E1.
Results show that the USF1 and APOA5 polymorphisms are associated with Familial combined hyperlipidemia and that the S19W SNP in the APOA5 gene is associated to the disease independently of total cholesterol, triglycerides and body mass index.
The carriers of minor alleles of rs2516839 (C) and rs1556259 (G) of USF1 gene had decreased USF1 expression in atherosclerotic plaques as compared to non-carriers.
Our results provided a new insight into susceptibility of USF1 variant with male infertility. rs11204546 of OR2W3 and rs11677854 of GTF2A1L might be additional valuable molecular predictive markers
CK2 phosphorylation of USF1 modulates two functionally important properties of USF1, namely hetero-dimerization and transactivation.
Further studies may be needed to validate our results and gain insights into the pathological mechanism of USF1 gene in the HCC tumorigenesis.
A significantly elevated genotype frequency in certain USF1 genes was observed in hepatocellular carcinoma patients.
Increased upstream stimulatory factor in HCC is associated with heparanase expression. USF might be an important factor in regulating HPSE expression and act as a novel marker of metastatic recurrence of HCC patients
They underscore the new role of USF1 and give new clues of how p53 loss of function can occur in any cell type.
USF1 binding to an E-box element may be critical for basal MVP promoter activation.
Knockdown of USF-1 protected the HepG2 cells from oxygen and glucose deprivation (OGD)-induced apoptosis.
The rs2516838 and rs2516839 polymorphisms of USF1 influence total unstable CPA in atherosclerotic stroke patients, which might be new markers to predict the risk of recurrence for this disease.
USF1 SNP's distribution and genetic risk for cardiovascular disease in Azoreans (Portugal)
study demonstrates that upstream transcription factor 1 (USF1) is a maternally derived transcription factor required for bovine early embryonic development
Depletion of the USFs by RNAi and expression of a dominant-negative USF mutant, were both associated with a significant decrease in P1.1-dependent reporter gene expression.
bovine upstream stimulatory factor 1 and 2 have roles regulating the prostaglandin G/H synthase-2 promoter in granulosa cells [USF1/USF2]
Mice lacking Usf1 displayed increased BAT-facilitated, diet-induced thermogenesis with up-regulation of mitochondrial respiratory chain complexes, as well as increased BAT activity even at thermoneutrality and after BAT sympathectomy
USF1 exclusively bound to the CACGTG E-box motifs in the brain cortex neuron proximal promoter regions. Importantly, functional annotation of the USF1-binding targets revealed an enrichment of genes related to lysosomal functions.
Propose that USF1 is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex.
USF1 but not USF2 supports OPN expression in LRP6-VKO vascular smooth muscle lineage, and immunoprecipitation confirmed increased USF1 association with OPN chromatin.
Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells.
USF1-centered regulatory networks were further confirmed by ChIP assays.
studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression
AGTRAP expression is regulated by USF1 and USF2
USF1 transactivates GATA5 expression by binding to the E-box in its promoter
Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors.
using a mouse model we show that the loss of USF-1 compromises DNA repair, which suggests that USF-1 plays an important role in maintaining genomic stability.
USF-1 binds the 5'PDbeta2 repressor element (E-box) in developing double-negative thymocytes.
critical transcription factor regulating diabetic kidney disease and plays a critical role in albuminuria, mesangial matrix accumulation, and TGF-beta1 and renin stimulation in diabetic kidney disease
USF regulates osteopontin gene transcription aortic vascular smooth muscle cells, entrained to changes in cellular glucose metabolism
USF binding to the E-box at -893/-888 serves to trans-repress basal expression and IL-1beta induction of the iNOS promoter.
USF1, along with ikaros-2, regulates delta opioid receptor expression in mouse T lymphocytes
USF1 and USF2 play a functional role in RANKL-dependent TRAP expression during osteoclast differentiation.
Data show that USF1/-2 and CREB transcription factors binding to the cyclooxygenase-2 promoter induced H. pylori-dependent cox-2 transcription.
UV-induced expression of POMC and MC1R is dependent on the p-38-activated upstream stimulating factor-1
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21.
upstream transcription factor 1 usf1
, upstream transcription factor 1
, upstream stimulatory factor 1
, major late transcription factor 1
, class B basic helix-loop-helix protein 11
, upstream stimulatory factor 1a
, Upstream stimulatory factor 1 (Major late transcription factor 1)