This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Alternative names and synonyms associated with Cofilin 2
cofilin 1 (cfl1) ELISA Kit
cofilin 1 (non-muscle) S homeolog (cfl1.S) ELISA Kit