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anti-Human Gelsolin Antibodies:
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Dog (Canine) Monoclonal Gelsolin Primary Antibody for IF, IP - ABIN967953
Arnt, Chiorean, Heldebrant, Gores, Kaufmann: Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. in The Journal of biological chemistry 2002
Show all 5 Pubmed References
Dog (Canine) Monoclonal Gelsolin Primary Antibody for IF, IP - ABIN2689519
De Botton, Sabri, Daugas, Zermati, Guidotti, Hermine, Kroemer, Vainchenker, Debili: Platelet formation is the consequence of caspase activation within megakaryocytes. in Blood 2002
Show all 5 Pubmed References
Cow (Bovine) Monoclonal Gelsolin Primary Antibody for ELISA, ICC - ABIN257868
Sezen, Bongiovanni, Gelber, Perni, Hutson, Skupski, Witkin: Gelsolin down-regulates lipopolysaccharide-induced intraamniotic tumor necrosis factor-alpha production in the midtrimester of pregnancy. in American journal of obstetrics and gynecology 2009
Show all 3 Pubmed References
Human Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN4313836
An, Kim, Jang, Kim, Kang, Choi: Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. in Biochemical and biophysical research communications 2011
Show all 2 Pubmed References
Human Polyclonal Gelsolin Primary Antibody for ICC, IF - ABIN443117
Yun-Hong, Chih-Fan, Chia-Wei, Yen-Chung: A study of the spatial protein organization of the postsynaptic density isolated from porcine cerebral cortex and cerebellum. in Molecular & cellular proteomics : MCP 2011
Show all 2 Pubmed References
Human Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN561152
Beck, Petersen, Nielsen, Morsczeck, Morszeck, Jensen, Sehested, Grauslund: Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat. in Electrophoresis 2010
Human Polyclonal Gelsolin Primary Antibody for ICC, IHC - ABIN1078060
Hergenroeder, Redell, Moore, Dubinsky, Funk, Crommett, Clifton, Levine, Valadka, Dash: Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure. in Journal of neurotrauma 2008
Human Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN4313834
Tanaka, Shirkoohi, Nakagawa, Qiao, Fujita, Okada, Hamada, Kuzumaki, Takimoto, Kuzumaki: siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells. in International journal of cancer. Journal international du cancer 2006
Human Monoclonal Gelsolin Primary Antibody for IHC, ELISA - ABIN1584495
Mashtoub, Tran, Howarth: Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats. in Experimental biology and medicine (Maywood, N.J.) 2014
Human Polyclonal Gelsolin Primary Antibody for IF (p), IHC (p) - ABIN738546
Wang, Yang, Liu, Zhou, Wu, Qiao, Li, Wang: Dietary supplementation with the probiotic Lactobacillus fermentum I5007 and the antibiotic aureomycin differentially affects the small intestinal proteomes of weanling piglets. in The Journal of nutrition 2011
Results identify GSN as target of miR (show MLXIP Antibodies)-200a which inhibits the release of microvesicles in hepatocellular carcinoma cells by functionally regulating GSN.
Gelsolin enhances the invasive capacity of colon cancer cells via elevating intracellular superoxide (O2.-) levels by interacting with Cu/ZnSOD (show SOD1 Antibodies), and gelsolin gene expression positively correlates with urokinase plasminogen (show PLG Antibodies) activator (uPA (show PRAP1 Antibodies)), an important matrix-degrading protease invovled in cancer invasion.
these data profile the importance of the physical interaction between HPV16 E7 and gelsolin in the acquisition of the metastatic phenotype by cervical cancer cells
Our study highlights gelsolin as an important pro-disseminative factor contributing to the aggressive phenotype of diffuse gastric cancer
study strongly supported the contribution of the genes ITGA2B, GSN and RHOA and the two pathways "regulation of actin cytoskeleton" and "leukocyte transendothelial migration" to osteoporosis risk.
SSH1 (show SSH1 Antibodies) binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 (show SSH1 Antibodies) in cell-free assays and in cultured cells.
free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.
analysis of how YopO disrupts normal gelsolin function to alter host actin dynamics and thus cripple phagocytosis
Our present study implied that the synergistic effect of pGSN and pIgA (show PIGA Antibodies) induced glomerular fibrosis via the TGF-beta1 (show TGFB1 Antibodies)/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.
The expression levels of GSN were observed to be reduced in colon carcinoma (CC) cells, and the reduced expression level of GSN was often associated with a poorer metastasisfree survival rate in patients with CC (P=0.04). In addition, the overexpression of GSN inhibited the invasion of CC cells in vitro.
model of the N-terminal extension on the surface of the gelsolin molecule, which was unknown previously
the observed structural transitions contribute to the stable binding of the second actin monomer in the ternary gelsolin-actin complex
gelsolin plays a critical role in airway smooth muscle relaxation.
We conclude that a nanobody-based gene therapy using adeno (show ADORA2A Antibodies)-associated viruses shows great potential as a novel strategy in gelsolin amyloidosis and potentially other amyloid diseases.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Antibodies) and actin mediated via gelsolin, suggesting that CCT (show FLVCR2 Antibodies) may influence processes depending on gelsolin activity, such as cell motility.
novel roles for actin-depolymerizing factor (show DSTN Antibodies) and cofilin-1 (show CFL1 Antibodies) in regulating the remodeling and permeability of epithelial junctions
The data of this study identify overlapping functions for ADF (show TXN Antibodies) and n-cofilin (show CFL1 Antibodies) in presynaptic physiology and vesicle in mice. trafficking.
Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes
Clic1 (show CLIC1 Antibodies) have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (show ANXA7 Antibodies) and Gelsolin.
our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3 (show ATF3 Antibodies)-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex
Plasma gelsolin levels decrease in the blood of mice with type II diabetes.
Ca2 (show CA2 Antibodies)+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin
Data show that scinla and scinlb have different expression patterns and developmental roles during zebrafish development.
Data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin (show SCIN Antibodies) gene, and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin.
The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
gelsolin (amyloidosis, Finnish type)
, drosophila gelsolin
, actin-depolymerizing factor
, C/L gelsolin
, gelsolin, like 1