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anti-Human Gelsolin Antibodies:
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Human Monoclonal Gelsolin Primary Antibody for IP, WB - ABIN532666
Deng, Zhu, Zeng, Zhang, Yu, Liu, Liu, Tian, Deng: Is GSN significant for hip BMD in female Caucasians? in Bone 2014
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Cow (Bovine) Monoclonal Gelsolin Primary Antibody for ELISA, ICC - ABIN257868
Sezen, Bongiovanni, Gelber, Perni, Hutson, Skupski, Witkin: Gelsolin down-regulates lipopolysaccharide-induced intraamniotic tumor necrosis factor-alpha production in the midtrimester of pregnancy. in American journal of obstetrics and gynecology 2009
Show all 3 Pubmed References
Human Polyclonal Gelsolin Primary Antibody for ICC, IF - ABIN443117
Yun-Hong, Chih-Fan, Chia-Wei, Yen-Chung: A study of the spatial protein organization of the postsynaptic density isolated from porcine cerebral cortex and cerebellum. in Molecular & cellular proteomics : MCP 2011
Show all 2 Pubmed References
Human Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN4313836
An, Kim, Jang, Kim, Kang, Choi: Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. in Biochemical and biophysical research communications 2011
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Human Polyclonal Gelsolin Primary Antibody for IF (p), IHC (p) - ABIN738546
Wang, Yang, Liu, Zhou, Wu, Qiao, Li, Wang: Dietary supplementation with the probiotic Lactobacillus fermentum I5007 and the antibiotic aureomycin differentially affects the small intestinal proteomes of weanling piglets. in The Journal of nutrition 2011
Dog (Canine) Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN547792
Tanaka, Shirkoohi, Nakagawa, Qiao, Fujita, Okada, Hamada, Kuzumaki, Takimoto, Kuzumaki: siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells. in International journal of cancer. Journal international du cancer 2006
Cow (Bovine) Polyclonal Gelsolin Primary Antibody for IHC, WB - ABIN2785642
Shokouhi, Khosroshahi: Ardalan-Shoja-Kiuru syndrome--hereditary gelsolin amyloidosis plus retinitis pigmentosa. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008
Human Polyclonal Gelsolin Primary Antibody for ELISA, WB - ABIN561152
Beck, Petersen, Nielsen, Morsczeck, Morszeck, Jensen, Sehested, Grauslund: Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat. in Electrophoresis 2010
Human Polyclonal Gelsolin Primary Antibody for ICC, IHC - ABIN1078060
Hergenroeder, Redell, Moore, Dubinsky, Funk, Crommett, Clifton, Levine, Valadka, Dash: Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure. in Journal of neurotrauma 2008
Human Polyclonal Gelsolin Primary Antibody for ICC, IHC (p) - ABIN3043978
Guo, Cui, Jiang, Zhang, Jiang: Proteomics of acute heart failure in a rat post-myocardial infarction model. in Molecular medicine reports 2018
the overall expression and the balance between GSN isoforms are mediating factors in proliferation, while increased overall expression of alternative splicing events-GSN is specific to cancer tissues.
High GSN expression is associated with colorectal cancer metastasis, mediating perineural and lymphovascular invasion.
increased activity in failing human hearts
Results suggest a cycle for gelsolin activity. Firstly, calcium activates ATP-bound gelsolin allowing it to sever and cap F-actin. Secondly, PIP2-binding removes the gelsolin cap from F-actin at low calcium levels, leading to filament elongation. Finally, ATP competes with PIP2 to release the calcium-free ATP-bound gelsolin, allowing it to undergo a further round of severing.
Data suggest that, in addition to the well-known proteolytic-dependent mechanism, an alternative oligomerization pathway may participate in gelsolin misfolding and aggregation.
the gelsolin N184K variant is subjected to the same aberrant proteolytic events responsible for the formation of amyloidogenic fragments in the previously characterized mutants.
Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin.
Gelsolin upregulation promotes radioresistance in non-small cell lung cancer cells, at least partially, through activation of phosphoinositide 3-kinase/Akt signaling.
Results identify GSN as target of miR-200a which inhibits the release of microvesicles in hepatocellular carcinoma cells by functionally regulating GSN.
Gelsolin enhances the invasive capacity of colon cancer cells via elevating intracellular superoxide (O2.-) levels by interacting with Cu/ZnSOD, and gelsolin gene expression positively correlates with urokinase plasminogen activator (uPA), an important matrix-degrading protease invovled in cancer invasion.
these data profile the importance of the physical interaction between HPV16 E7 and gelsolin in the acquisition of the metastatic phenotype by cervical cancer cells
Our study highlights gelsolin as an important pro-disseminative factor contributing to the aggressive phenotype of diffuse gastric cancer
study strongly supported the contribution of the genes ITGA2B, GSN and RHOA and the two pathways "regulation of actin cytoskeleton" and "leukocyte transendothelial migration" to osteoporosis risk.
SSH1 binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.
free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.
analysis of how YopO disrupts normal gelsolin function to alter host actin dynamics and thus cripple phagocytosis
Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-beta1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.
The expression levels of GSN were observed to be reduced in colon carcinoma (CC) cells, and the reduced expression level of GSN was often associated with a poorer metastasisfree survival rate in patients with CC (P=0.04). In addition, the overexpression of GSN inhibited the invasion of CC cells in vitro.
in chronic hemodialysis patients, lower pGSN levels were not associated with hospitalization, all-cause and cardio-vascular mortality, even though pGSN was inversely correlated with age, CRP and IL-6, suggesting that inflammation may influence pGSN
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
PI3Kalpha drives gelsolin-mediated adverse cytoskeletal remodeling in response to biomechanical stress.
Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
gelsolin plays a critical role in airway smooth muscle relaxation.
We conclude that a nanobody-based gene therapy using adeno-associated viruses shows great potential as a novel strategy in gelsolin amyloidosis and potentially other amyloid diseases.
The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin, suggesting that CCT may influence processes depending on gelsolin activity, such as cell motility.
novel roles for actin-depolymerizing factor and cofilin-1 in regulating the remodeling and permeability of epithelial junctions
The data of this study identify overlapping functions for ADF and n-cofilin in presynaptic physiology and vesicle in mice. trafficking.
GSNs might play a regulatory role in the suppression of the tissue damage induced by acute radiation exposure
Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes
Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 and Gelsolin.
our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex
Plasma gelsolin levels decrease in the blood of mice with type II diabetes.
The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Burn-induced cerebral gelsolin expression is involved in the activation of both monocytes and astroglial cells, thereby playing a crucial role in the subsequent inflammation-induced neural apoptosis following burn injury.
study concludes that cell adhesion to collagen presented on beads activates Ca(2 ) entry and promotes the formation of phagosomes enriched with NMMIIA and gelsolin
The F-actin severing activity of ADF/Co fi lin organizes space for the protrusion and bundling of microtubules, the backbone of neurites. ADF/Co fi lin organizes the cytoskeleton to drive actin retrograde fl ow and thus break the spherical shape of neurons.
Gelsolin deficiency alters the equilibrium between erythrocyte actin polymerization and depolymerization, causing impaired terminal maturation.
data support a mechanistic model for gelsolin's role in insulin exocytosis: gelsolin clamps unsolicited soluble N-ethylmaleimide-sensitive factor attachment receptor-regulated exocytosis through association with Syn4 which is relieved upon stimulus-induced calcium influx to activate gelsolin to facilitate insulin exocytosis
model of the N-terminal extension on the surface of the gelsolin molecule, which was unknown previously
the observed structural transitions contribute to the stable binding of the second actin monomer in the ternary gelsolin-actin complex
Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin
The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
, gelsolin (amyloidosis, Finnish type)
, drosophila gelsolin