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anti-Mouse (Murine) FERMT2 Antibodies:
anti-Human FERMT2 Antibodies:
anti-Rat (Rattus) FERMT2 Antibodies:
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Human Monoclonal FERMT2 Primary Antibody for IF, ELISA - ABIN564761
Dowling, Vreede, Kim, Golden, Feldman: Kindlin-2 is required for myocyte elongation and is essential for myogenesis. in BMC cell biology 2008
Kindlin-2 is a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2 (show AICDA Antibodies)/3 complex.
demonstration that Smurf1 (show SMURF1 Antibodies) acts as a brake for integrin activation by controlling Kindlin-2 protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions
Postnatal loss of Kindlin-2 from cardiac myocytes leads to progressive heart failure.
Data indicate that Kindlin-2 not only maintains the cardiac structure but also is required for cardiac function.
These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Antibodies) binding and adhesion.
These studies uncover a previously unrecognized function for Kindlin-2 and a mechanism for regulation of the chondrocyte differentiation programme and chondrogenesis.
Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of colorectal carcinoma
Data suggest that kindlin-2 (Kind2/Fermt2) interacts with actin alpha 2 (Actn2 (show ACTN2 Antibodies)) and integrin beta 1 (Itgb1 (show ITGB1 Antibodies)) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Actn2 (show ACTN2 Antibodies) and Itgb1 (show ITGB1 Antibodies).
beta3/kindlin-2 interaction promotes outside-in alphaVbeta3 signaling selectively, with biological consequences in vivo [kindlin-2]
kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signaling circuit controlling cell migration and proliferation
Kindlin-2 is up-regulated in glioma cells and acts as an oncogene (show RAB1A Antibodies). It is an independent risk factor for poor prognosis. The Kindlin-2/YB-1 (show YBX1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) complex promotes EGFR (show EGFR Antibodies) transcription and contributes to glioma progression. Kindlin-2 is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 may be a novel strategy for glioma treatment.
the rs17125944 polymorphism in FERMT2 gene might not be association with late-onset Alzheimer's disease in northern Han Chinese population
analysis of the Kindlin-2-RhoGDIalpha-Rac1 signaling axis that is critical for regulation of podocyte structure and function in vivo
Study found that FERMT2 (a beta3-integrin (show ITGB3 Antibodies) co-activator) was significantly associated with a variation in cerebrospinal fluid Abeta (show APP Antibodies) peptide levels in 2886 Alzheimer's disease cases.Under-expression of FERMT2 increases Abeta (show APP Antibodies) peptide production by raising levels of mature APP (show APP Antibodies) at the cell surface and facilitating its recycling
High kindlin 2 expression is associated with Breast Cancer.
Data suggest that the extreme C terminus of kindlin-2 is essential for interaction with and activation of integrin alphaIIBbeta3; these studies were conducted in macrophage cell line and erythroleukemia cell line.
We show a direct relationship between kindlin-1 (show FERMT1 Antibodies) abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 overexpression has no compensatory effect.
The F0 domain of K2 binds actin.
data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB (show NFKB1 Antibodies)-dependent upregulation of MMP-9 (show MMP9 Antibodies) and MMP-2 (show MMP2 Antibodies)
High kindlin-2 expression is associated with esophageal squamous cell carcinoma.
Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites (By similarity).
fermitin family homolog 2
, mitogen inducible 2
, pleckstrin homology domain containing, family C (with FERM domain) member 1
, pleckstrin homology domain-containing family C member 1
, PH domain-containing family C member 1
, kindlin 2
, mitogen inducible gene 2 protein
, mitogen-inducible gene 2 protein
, pleckstrin homology domain containing, family C member 1