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anti-Human Laminin alpha 5 Antibodies:
anti-Mouse (Murine) Laminin alpha 5 Antibodies:
anti-Rat (Rattus) Laminin alpha 5 Antibodies:
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Human Monoclonal Laminin alpha 5 Primary Antibody for ELISA, WB - ABIN561641
Maynard, Heijnen, Horne, White, Gahl: Proteomic analysis of platelet alpha-granules using mass spectrometry. in Journal of thrombosis and haemostasis : JTH 2007
Show all 4 Pubmed References
Human Polyclonal Laminin alpha 5 Primary Antibody for ELISA, WB - ABIN561640
Kariya, Sato, Katou, Kariya, Miyazaki: Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration. in PLoS ONE 2012
Human Polyclonal Laminin alpha 5 Primary Antibody for ELISA - ABIN4229153
De Luca, Crocco, Wiener, Tiwari, Passarino, Rose: Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects. in Experimental gerontology 2010
Data suggest that laminin alpha5, which is concentrated at the distal ends of the fins, organizes the distal cells of the fin fold and pectoral fins in order to promote the morphogenesis of the epidermis.
This report links a LAMA5 variant with familial microscopic hematuria.
Analysis of individual U251MG cells revealed lama5 significantly lowered invasion as mobile U251MG cells traveled 32.5mum less, invaded 5.0mum/hr slower and initiated invasion 60% few times per cell.
this report describing severe neuromuscular transmission failure in a patient with a LAMA5 mutation expands the list of phenotypes associated with defects in genes encoding alpha-laminins.
Laminin subunit alpha 5 downregulation is associated with Preeclampsia (PE) placenta and impairs trophoblast viability and invasiveness, which could be a causative factor of PE pathogenesis.
Lu/BCAM-mediated binding to laminin-alpha5 is restricted by interacting, in cis, with glycophorin-C-derived sialic acid residues.
The finding of rare LAMA5 variants together with FLT4 and FOXC2 mutations in Milroy disease and lymphedema-distichiasis syndrome suggests that these mutations may be co-responsible for these disorders and most likely interfere with the function of lymphatics.
This study shows that specific laminin alpha5 substrates provide a controlled in vitro culture environment for human pluripotent stem cells-derived neurons.
study describes the first LAMA5 mutation that causes a novel complex extracellular matrix syndrome
data show that the BCAM/LAMA5 system plays a functional role in the metastatic spreading of KRAS-mutant colorectal cancer
Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review)
Taken together, these data suggest that alpha5-containing laminins repress intestinal differentiation in its early stages.
We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
The Laminin-511 consists of alpha5, beta1, and gamma1 chains, of which three laminin globular domains of the alpha5 chain (alpha5/LG1-3) and a Glu residue in the C-terminal tail of chain gamma1 (gamma1-Glu1607) are required for binding to integrins.
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers.
Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
The laminin-5 staining pattern was significantly more often continuous in severe dysplasia/carcinoma-in-situ
mechanistic role of laminin-511 in tissue homeostasis
the overriding effect of laminin 511 in the skin is inhibition of basal keratinocyte proliferation and migration.
Study found that the extracellular matrix protein laminin-511 (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP.
Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation
The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress.
According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time.
Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
Laminins affect T cell trafficking and allograft fate.
Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold.
These results suggest that laminin trimers containing alpha5 that are synthesized and secreted by endothelium or by trophoblasts are capable of integrating into the basement membrane and promoting normal vascularization of the placenta.
alpha1- and alpha5-containing laminins differentially regulate the sequential events to form epithelial tissues via beta1 integrin signals.
amino acid residues within the short arm region of alpha5 that were critical for neurite outgrowth activity
most of the integrin-mediated cell adhesive peptides are located in the loop regions in the G domains, suggesting that structure is important for the integrin specific recognition
crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network
Data provides support for a primary role of laminin-511 and integrin beta-1 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction.
Downregulation of laminin-511 is important for hair regression.
role in lobar septation and visceral pleural basement membrane formation in developing mouse lung
several peptides of Laminin alpha 5 had cell attachment activity and the ability to promote neurite outgrowth.
Results demonstrate that the alpha5 LG3 module is essential for the Lutheran blood group glycoprotein (Lu) binding to laminin alpha5.
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
, laminin subunit alpha-5
, unm m538
, laminin, alpha 5
, laminin subunit alpha-5-like
, laminin alpha-5 chain
, laminin-10 subunit alpha
, laminin-11 subunit alpha
, laminin-15 subunit alpha