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Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy.
Expression of p63-tGFP induces apoptosis with marked increase in PERP expression and associated p53 accumulation. Lack of p63 contributes to reduced PERP levels and impaired p53-mediated apoptosis in UM.
Salmonella Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface.
The authors identified the tetraspanning membrane protein, p53 effector related to PMP-22 (PERP), as a Salmonella typhimurium SipA binding partner.
Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.
Perp expression is reduced in human breast cancer cell lines
PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells.
Our comprehensive mutation scanning did not identify any Arrhythmogenic right ventricular cardiomyopathy (ARVC) causing mutations.
Data suggest a temporal sequence whereby PERP loss occurs before E-cadherin loss in the progression of human SCC.
findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by uveal melanoma tumours to modulate susceptibility to apoptosis
pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation
We demonstrate here that PERP induction is in fact compromised with some, but not all, Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate, AEC-patient derived TP63 mutants.
A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest.
Perp deletion promoted Th17 responses and exacerbated the development and severity of experimental autoimmune encephalomyelitis.
Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation
an important role for Perp in normal mammary tissue function and in mammary cancer suppression
Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation.
Studies suggest that Perp-deficiency promotes cancer by enhancing cell survival, desmosome loss, and inflammation, and they highlight a fundamental role for Perp and desmosomes in tumor suppression.
In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation
Perp is a key effector in the p63 developmental program.
Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings.
Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment.
Perp is requered throughout adult life for proper epithelial homeostasis and function.
PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia.
In contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival.
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
, keratinocyte-associated protein 1
, keratinocytes associated protein 1
, p53 apoptosis effector related to PMP-22
, p53 apoptosis effector related to PMP22
, p53-induced protein PIGPC1
, transmembrane protein THW
, p53 apoptosis effector related to Pmp22
, p53 apoptosis-associated target
, PERP, TP53 apoptosis effector
, p53 apoptosis effector related to pmp-22