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we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt
A mutation in TAOK2 appears to cause a novel form of primary immunodeficiency, characterized by an impaired T cell proliferation upon activation.
tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases.
TAOK2 is essential for dendrite morphogenesis; TAOK2 downregulation impairs basal dendrite formation without affecting apical dendrites.
PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity
mediates signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors
the TAK1-JNK pathway is activated by osmotic stress, while blocking TAK1-mediated NF-kappaB activation; TAO2 regulates TAK1 pathways
PSK1-alpha is a bifunctional kinase that associates with microtubules, and JNK- and caspase-mediated removal of its C-terminal microtubule-binding domain permits nuclear translocation of the N-terminal region of PSK1-alpha and its induction of apoptosis
disruption of the Taok2 gene alters behavioral response to ethanol.
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, kinase from chicken homolog C
, prostate derived STE20-like kinase PSK
, prostate-derived STE20-like kinase 1
, prostate-derived sterile 20-like kinase 1
, serine/threonine-protein kinase TAO2
, thousand and one amino acid protein kinase 2
, serine-threonine kinase
, serine/threonine protein kinase TAO2
, thousand and one amino acid protein 2
, TAO kinase 2TAO kinase 2
, TAO kinase 2
, serine/threonine-protein kinase TAO2-like