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anti-Human TGFB2 Antibodies:
anti-Mouse (Murine) TGFB2 Antibodies:
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Human Polyclonal TGFB2 Primary Antibody for IHC (p), WB - ABIN1882140
Hatsushika, Hirota, Harada, Sakashita, Kanzaki, Takano, Doi, Fujita, Enomoto, Ebisawa, Yoshihara, Sagara, Fukuda, Masuyama, Katoh, Matsumoto, Saito, Ogawa, Tamari, Nakao: Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma. in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007
Show all 4 Pubmed References
Human Polyclonal TGFB2 Primary Antibody for WB - ABIN4359074
Lin, Teo, Lam, Jeyaseelan, Wang: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. in Cell death & disease 2012
High Tgfb2 expression is associated with ocular hypertension.
Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFbeta2 mediated pathway
Furthermore, upregulation of miR-328 could further repress the expression of TGF-beta2 and ECM proteins. In conclusion, this study demonstrated that miR-328 could prevent renal fibrogenesis by directly targeting TGF-beta2. Our findings suggested that elevated renal miR-328 levels might be a novel therapeutic strategy for treating renal fibrosis
Importantly, high expression levels of HIF-1alpha/TGF-beta2/GLI2 correlated robustly with the patient relapse following chemotherapy, highlighting a potential biomarker and therapeutic target for chemoresistance in colorectal cancer.
these data suggest that miR-592 may exert it suppressive role in breast cancer, at least in part, by targeting TGFbeta-2, and that miR-592 may be a novel target for breast cancer treatment
MicroRNA-486-5p suppresses TGFB2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2.
Results show that TGF-beta2 is highly expressed in glioma and correlated with poor prognosis in glioma patients. Further findings elucidate a potential mechanism of autophagy-associated glioma invasion that TGF-beta2 could initiate autophagy via Smad and non-Smad pathway to promote glioma cells' invasion.
Up-regulation of TGF-beta2 showed a strong association with muscle invasion in bladder cancer.
Breast milk immunomodulators TGFbeta1 and TGFbeta2 were significantly associated with neonatal gut microbial composition (R = 0.024, P = 0.041; R = 0.026, P = 0.012, respectively) and increased richness, evenness, and diversity, but IL-10 was not. The effects of TGFbeta1 and TGFbeta2, however, were not independent of one another, and the effect of TGFbeta2 was stronger than that of TGFbeta1.
Report early adaptive drug-escape in EGFR-mutant lung tumor cells dependent on TGFbeta2-bioenergetics-mitochondrial priming.
The expression of TGFB2 obtained by microarray analysis was consistent with that of RT-PCR. Ion transport could be affected promptly after ANP treatment, and subsequently, the cytolysis of vein endothelial cells may be promoted and endothelial permeability would be enhanced, followed by activated immune responses.
Data indicate that TGFb1 and TGFb3, but not TGFb2, showed higher expression levels in invasive breast cancer compared to normal tissues.
4.7 Mb deletion encompassing TGFB2 is associated with features of Loeys-Dietz syndrome and osteoporosis.
results imply that the interaction of matrix AGEs with RAGE plays a role in the TGFbeta2-mediated EMT of lens epithelial cells and suggest that the blockade of RAGE could be a strategy to prevent PCO and other age-associated fibrosis.
Data show that just like TGF-beta1, TGF-beta2 is expressed in and secreted by both, healthy and diseased hepatocytes and hepatic stellate cell (HSCs).
results support that the regulation of miR-30b by VEGF in HUVEC is important for capillary morphogenesis, as increased miR-30b expression inhibits capillary morphogenesis through enhanced expression of TGFbeta2
Data suggest that TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust/rapid response in small intestinal mucosal cells leading to stimulation of Egr1 transport to nucleus and cell differentiation; more than 15 Wnt signaling pathway genes have Egr1 binding sites/response elements; Egr1 binds to Axin1 promoter and functionally activates gene expression. (Axin1 = axis inhibition protein 1)
Hypoxia enhances canonical TGFbeta signalling, and appears to be a key determinant of Snail's differential involvement in endothelial cell responses to TGFbeta1 versus TGFbeta2.
RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
High TGFbeta2 expression is associated with oral cancer.
Suggest that the interplay between TGFbeta-2 and LPS regulates the levels of IL-8 in the immature newborn intestine.
TGFbeta may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in luteinizing pig follicles.
Study points toward elevated levels of active TGF-beta as inducers and promoters of ectopic bone formation, and suggest that TGF-beta might be a therapeutic target in heterotopic ossification.
data suggest a mechanism whereby a stromal hedgehog-TGFbeta2 signaling axis acts to control nephrogenesis.
TGF-beta2 as the crucial mediator of neural precursor cell immunomodulation.
CREBH was identified as a key positive regulator of TGF-beta2 transcription in hepatitis C virus-infected cells.
The disruption of decorin-restricted TGFbeta signalling leads to higher stiffness of articular cartilage matrix, rendering joints more resistant to osteoarthritis.
These data provide new insights in the molecular interaction between Fibulin-4 and TGF-beta pathway regulation in the pathogenesis of aortic aneurysms.
APC-derived TSP-1 is essential for the development of an adaptive regulatory immune response induced by TGF-beta2-expressing APCs similar to those located at mucosal and ocular sites.
Epidermal Tgfb2 controls proliferation, differentiation and ECM production by reticular fibroblasts.
Pathological TGF-beta release from osteolytic bone metastases contributes to muscle weakness in cancer by decreasing Ca(2+)-induced muscle force production.
Thus, along with TGF-b and MAPK signaling, NFkappaB serves as an important regulatory pathway which following Losartan treatment
Expression of TGFbeta2 was induced in response to elevated canonical Wnt signaling in dystrophic muscles and that the resulting increase in TGFbeta activity affected the behavior of satellite cells in an autocrine or paracrine fashion.
Strain-dependent effects of transforming growth factor-beta1 and 2 during mouse secondary palate development.
these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway.
TGFbeta2 regulates hypothalamic TRH expression through TIEG1 during fetal development.
These findings indicate that the lens epithelium of MCT mice has increased expression of TGFb1 and Tgfb2 before cataract affection and that changes in the expression of FGF2 as well as TGFbeta may contribute to the progression of the cataract in the mice.
Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor beta2 (TGF-beta2) pathways
work reveals a 'seed and soil' mechanism where TGF-beta2 and TGF-beta-RIII signalling through p38alpha/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
The results of this study found that Bptf and TGF-beta/Smad2 mediate nucleosome remodeling to regulate wnt8a expression and hence neural posteriorization.
Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis.
These data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
Topical Tamoxifen can reduce the content of TGF-beta2and decrease fibroblast density and in hypertrophic scars on rabbit ears.
There was no significant change in the expression of TGF-beta(2) and alpha-SMA after laser-assisted intrastromal scanning.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1\;7)(q41\;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
BSC-1 cell growth inhibitor
, glioblastoma-derived T-cell suppressor factor
, transforming growth factor beta-2
, TGF-beta 2
, Transforming growth factor beta-2
, transforming growth factor beta 2
, tgf beta 2
, transforming growth factor, beta 2
, milk growth factor
, transforming growth factor-beta 2
, transforming growth factor beta-2-like
, TGF beta 2 protein
, transforming growth factor-beta2
, TGF beta 2