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Human Polyclonal ZNF703 Primary Antibody for ELISA, WB - ABIN250795
Garcia, Pole, Chin, Teschendorff, Naderi, Ozdag, Vias, Kranjac, Subkhankulova, Paish, Ellis, Brenton, Edwards, Caldas: A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. in Oncogene 2005
Human Polyclonal ZNF703 Primary Antibody for ICC, IF - ABIN4367532
Holland, Burleigh, Git, Goldgraben, Perez-Mancera, Chin, Hurtado, Bruna, Ali, Greenwood, Dunning, Samarajiwa, Menon, Rueda, Lynch, McKinney, Ellis, Eaves, Carroll, Curtis, Aparicio, Caldas: ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. in EMBO molecular medicine 2011
ZNF703 may have potential as a therapeutic target.
ZNF703 can potently facilitate tumor growth and metastasis in many respects throughout the progression of CCA, which may act as an oncogene in CCA and can be considered as a novel potential therapeutic target.
ZNF703 activated the PI3K/AKT/GSK-3beta signalling pathway and its downstream effectors, thus regulating the cell cycle and epithelial-mesenchymal transition.
Results show that ZNF703 is up-regulated in 63.4% of non-small cell lung cancer (NSCLC) tumor samples and it may contribute to tumor development by activating the Akt/mTOR pathway in NSCLC.
In vitro function assays demonstrated that SPRY4-IT1 cause promotion of cell viability in ESCC cells. Authors further verified that SPRY4-IT1 could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4-IT1 in ESCC cells.
Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm.
ZNF703 was a target of SPRY4-IT1.
Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene in CRC.
The results showed that ZNF703 acts as a gastric cancer oncogene
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen.
The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.
ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells.
These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer.
Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53.
Results provide evidence that Zfp703 is a novel feedback suppressor of Wnt/beta-catenin signaling that functions by inhibiting the association of beta-catenin with Tcf1 on Wnt response elements in target gene enhancers.
Zeppo1 is a key regulator of breast cancer progression
Nlz1 is required for cilia formation in zebrafish embryogenesis.
nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon.
Nlz1/Znf703 acts as a repressor of transcription
identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
zinc finger elbow-related proline domain protein 1
, ES neuronal differentiation 2
, nocA related zinc finger 1
, nocA-like zinc finger protein 1
, nocA-related zinc finger protein 1