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Strong ERK (show MAPK1 Proteins) activation can target Cdc25A (show CDC25A Proteins) for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 Proteins) for cell cycle arrest.
SAG/RBX2 (show RNF7 Proteins) E3 ligase complexes with UBCH10 (show UBE2C Proteins) and UBE2S (show UBE2S Proteins) ubiquitin-conjugating enzymes to ubiquitylate beta-TrCP1 via K11-linkage for degradation.
Data indicate the role of tyrosine kinase (show TXK Proteins) c-Src (Src (show SRC Proteins)) in rescuing Taz (transcriptional coactivator with PDZ-binding motif (show WWTR1 Proteins)) from E3 ligase SCF (show KITLG Proteins)(beta-TrCP)-mediated degradation.
SCFbeta-TRCP negatively regulates the FLCN (show FLCN Proteins) complex by promoting FNIP2 (show FNIP2 Proteins) degradation in Birt-Hogg-Dube syndrome-associated renal cancer.
beta-TRCP depletion in HepG2 hepatocellular carcinoma cells resulted in increased Lipin1 protein abundance.
It demonstrates that degradation of Lipin-1 (show LPIN1 Proteins) is regulated by BTRC in the cytoplasm and on membranes
we identified two independent SNPs (i.e., WNT2B (show WNT2B Proteins) rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
It has been proposed that CENP-W (show CENPW Proteins) may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.
oncogenic effect of miR (show MLXIP Proteins)-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR (show MLXIP Proteins)-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H (show CREB3L3 Proteins).
Phosphorylated VEGFR-2 (show KDR Proteins) was reduced by hyperglycemia while total VEGFR-2 (show KDR Proteins) was almost unaltered. However, VEGFR-2 (show KDR Proteins) was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2 (show KDR Proteins).
beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 (show DMRT1 Proteins) for degradation.
Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 (show LPIN1 Proteins) stability.
betaTrCP levels are correlated with imiquimod-induced skin lesion.
beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
Erbin (show ERBB2IP Proteins) as a novel substrate of SAG (show RNF7 Proteins)-betaTrCP E3 ligase.
these results clearly suggest that both beta-TrCP- and Hrd1 (show SYVN1 Proteins)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Proteins) to maintain cellular homeostasis.
beta-TrCP may be an essential player in UVB induced responses in skin
Glycogen synthase kinase 3 (show GSK3a Proteins) phosphorylates a group of Ser (show SIGLEC1 Proteins) residues in the Neh6 domain of mouse Nrf2 (show NFE2L2 Proteins) that overlap with an SCF (show KITLG Proteins)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (show KEAP1 Proteins)-independent manner.
LPS (show TLR4 Proteins) appears to destabilize the LPCAT1 (show LPCAT1 Proteins) protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.
the two beta-TrCP paralogs have a nonredundant role in spermatogenesis
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
beta-transducin repeat containing
, beta-transducin repeat containing protein
, F-box/WD repeat-containing protein 1A
, f-box/WD repeat-containing protein 1A-like
, F-box and WD repeats protein beta-TrCP
, F-box and WD-repeat protein 1B
, epididymis tissue protein Li 2a
, pIkappaBalpha-E3 receptor subunit
, beta-transducin repeat-containing protein
, SCF b-TRCP
, beta-TrCP protein E3RS-IkappaB
, pIkappaB-E3 receptor subunit
, ubiquitin ligase FWD1