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Our findings indicate that aberrant CDK7 overexpression associates with T-stage and reduced survival in oral squamous cell carcinoma.
CDK7-mediated Ser-175 phosphorylation is a downstream nuclear event essential for facilitating CDK9 T-loop interactions with Tat
Study demonstrate that CDK7 activity is necessary to maintain the transcriptional program induced by STAT proteins that are activated both aberrantly by mutation and by extracellular cues in T-cell lymphomas.
these results implicate a CDK7-dependent "CTD code" that regulates chromatin marks in addition to RNA processing and pol II pausing.
Our studies have demonstrated the essential role of endogenous PRL and CDK7 in the upregulation of PRLR by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR and its participation in breast cancer progression fueled by E2 and PRL via their cognate receptors.
Expressions of components of the CAK complex, CDK7, MAT1, and Cyclin H are elevated in breast cancer.
MYC promotes mRNA cap methylation and protein production of Wnt/beta-catenin signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters.
High expression of MMP14 and CDK7 was independent prognostic factors for overall survival in patients with gastric cancer.
Taken together, these findings elucidated a novel mechanism of prostate cancer progression. Thus, SNHG1 might serve as a potential target for prostate cancer therapies.
Data indicate that cyclin dependent kinase 7 (CDK7) is overexpressed in gastric cancer cell lines and tissues.
Cdk7 broadly influences transcription and capping.
Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
Study shows that triple-negative but not hormone receptor-positive breast cancer cells are exceptionally dependent on CDK7, a transcriptional cyclin-dependent kinase.
Data suggest a quantitative contribution of CDK7 to mRNA synthesis, which is critical for cellular homeostasis.
Data indicate that TG02 blocked signaling by CDKs 1, 2, 7, and 9 and ERK5, leading to potent and highly consistent antimyeloma activity.
CDK7 involved in phosphorylation/activation of CDK4 and CDK6; existence of CDK4-activating kinase(s) other than CDK7; and novel CDK7-dependent positive feedbacks mediated by p21 phosphorylation by CDK4 and CDK2 to sustain CDK4 activation.
CCNH and CDK7 may play an important role in the tumorigenesis and development of esophageal squamous cell carcinoma.
Activating phosphorylation of Cdk7 rises concurrently with that of Cdk4 as cells exit quiescence and accelerates Cdk4 activation in vitro.
Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration
three CTD kinases, CDK7, CDK9, and BRD4, engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7
the cyclin-dependent kinase CDK7 is regulated by miR-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development
Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 and Cdk2. In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development.
investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity
results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity
Inhibition of SF-1-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1.
Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Genetic and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH. Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II.
CDK7 is required for the mitochondrial localization of Hid and induction of apoptosis.
The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Cdk7 is required for full activation of Drosophila heat-shock genes and RNA polymerase II phosphorylation in vivo.
Analysis of Cdk7 expression in unfertilized eggs, embryos and organs of adult zebrafish suggests that Cdk7 message is maternally loaded; its transcript is detected throughout early embryonic development.
CDK7 and CCNH activate CDC2 by T161 phosphorylation and make up CDK-activating kinase, which is required for normal meiotic progression during porcine oocyte maturation.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
39 KDa protein kinase
, CDK-activating kinase 1
, TFIIH basal transcription factor complex kinase subunit
, cell division protein kinase 7
, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
, homolog of Xenopus MO15 Cdk-activating kinase
, kinase subunit of CAK
, p39 Mo15
, protein kinase
, serine/threonine kinase stk1
, serine/threonine protein kinase 1
, serine/threonine protein kinase MO15
, serine/threonine-protein kinase 1
, 39 kDa protein kinase
, CDK-activating kinase
, CR4 protein kinase
, CRK4 PK (CDC2-related-kinase-4 protein kinase)
, P39 Mo15
, cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
, protein-tyrosine kinase MPK-7
, 39 protein kinase
, cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase)
, 40 kDa protein kinase
, CDC2/CDK2,4-activating kinase
, P40 MO15
, cyclin-dependent kinase 7 (MO15, cdk-activating kinase)
, cell division protein kinase 7-like protein