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these results implicate a CDK7-dependent "CTD code" that regulates chromatin marks in addition to RNA processing and pol II pausing.
Our studies have demonstrated the essential role of endogenous PRL (show PRL Proteins) and CDK7 in the upregulation of PRLR (show PRLR Proteins) by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR (show PRLR Proteins) and its participation in breast cancer progression fueled by E2 and PRL (show PRL Proteins) via their cognate receptors.
Expressions of components of the CAK complex (show CCNH Proteins), CDK7, MAT1 (show MAT1A Proteins), and Cyclin H (show CCNH Proteins) are elevated in breast cancer.
MYC (show MYC Proteins) promotes mRNA cap methylation and protein production of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling transcripts through recruitment of cyclin-dependent kinase 7 (CDK7) and consequently RNMT to gene promoters.
High expression of MMP14 (show MMP14 Proteins) and CDK7 was independent prognostic factors for overall survival in patients with gastric cancer.
Taken together, these findings elucidated a novel mechanism of prostate cancer progression. Thus, SNHG1 might serve as a potential target for prostate cancer therapies.
Data indicate that cyclin dependent kinase 7 (CDK7) is overexpressed in gastric cancer cell lines and tissues.
Cdk7 broadly influences transcription and capping.
Our results indicated that CCNH (show CCNH Proteins)/CDK7-CtBP2 (show CTBP2 Proteins) axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma .
Study shows that triple-negative but not hormone receptor (show NR4A1 Proteins)-positive breast cancer cells are exceptionally dependent on CDK7, a transcriptional cyclin-dependent kinase (show CDK1 Proteins).
the cyclin-dependent kinase (show CDK1 Proteins) CDK7 is regulated by miR (show MLXIP Proteins)-210 and is necessary for normal NP cell-cycle progression. Our findings demonstrate that miRNAs are essential for normal NP proliferation and cell-cycle progress during neocortical development
Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Whereas Cdk7 was completely dispensable for global transcription, it was essential for the cell cycle via phosphorylation of Cdk1 (show CDK1 Proteins) and Cdk2 (show CDK2 Proteins). In vivo, Cdk7 was indispensable for cell proliferation except during the first stages of embryonic development.
investigated the function of the Cdk7.cyclin (show PCNA Proteins) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Cdk7 kinase activity and cell cycle kinetics were found to be comparable in wild-type and Hint(-/-) mouse embryonic fibroblasts, suggesting that Hint may not be a key regulator of Cdk7 activity
results demonstrate that the Cdk7 submodule of transcription factor IIH acts as a physiological roadblock to adipogenesis by inhibiting PPARgamma (show PPARG Proteins) activity
Inhibition of SF-1 (show SF1 Proteins)-mediated transcription by SUMOylation in adrenocortical cancer cells is mediated through reduced CDK7-induced phosphorylation of SF-1 (show SF1 Proteins).
Mms19 (show MMS19 Proteins) is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase.
Genetic and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex (show CCNH Proteins) of the general transcription factor TFIIH (show GTF2H5 Proteins). Importantly, MSL1 depletion leads to decreased phosphorylation of Ser5 of RNA polymerase II.
CDK7 is required for the mitochondrial localization of Hid and induction of apoptosis.
The multitask protein Xpd (show ERCC2 Proteins) also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Cdk7 is required for full activation of Drosophila heat-shock genes and RNA polymerase II phosphorylation in vivo.
Analysis of Cdk7 expression in unfertilized eggs, embryos and organs of adult zebrafish suggests that Cdk7 message is maternally loaded; its transcript is detected throughout early embryonic development.
CDK7 and CCNH (show CCNH Proteins) activate CDC2 (show CDK1 Proteins) by T161 phosphorylation and make up CDK-activating kinase, which is required for normal meiotic progression during porcine oocyte maturation.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
39 KDa protein kinase
, CDK-activating kinase 1
, TFIIH basal transcription factor complex kinase subunit
, cell division protein kinase 7
, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
, homolog of Xenopus MO15 Cdk-activating kinase
, kinase subunit of CAK
, p39 Mo15
, protein kinase
, serine/threonine kinase stk1
, serine/threonine protein kinase 1
, serine/threonine protein kinase MO15
, serine/threonine-protein kinase 1
, 39 kDa protein kinase
, CDK-activating kinase
, CR4 protein kinase
, CRK4 PK (CDC2-related-kinase-4 protein kinase)
, P39 Mo15
, cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
, protein-tyrosine kinase MPK-7
, 39 protein kinase
, cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase)
, 40 kDa protein kinase
, CDC2/CDK2,4-activating kinase
, P40 MO15
, cyclin-dependent kinase 7 (MO15, cdk-activating kinase)
, cell division protein kinase 7-like protein