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We unexpectedly found that p19INK4d plays an important role in human terminal erythropoiesis
p19(INK4D) is one of the key mediators of miR (show MLXIP Proteins)-125b activity during the onset of megakaryocyte polyploidization.
p19 may play an important role in the ototoxic effects of cisplatin and is probably involved in the pathogenesis of hearing loss.
MiR (show MLXIP Proteins)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D and MAP3K1 (show MAP3K1 Proteins) expression.
Data indicate that upon oxidative DNA damage, cyclin-dependent kinase (show CDK1 Proteins) inhibitor p19INK4d strongly binds to and relaxes chromatin.
CDKN2D repression by PML (show PML Proteins)/RARalpha (show RARA Proteins) disrupts both cell proliferation and differentiation in the pathogenesis of acute promyelocytic leukemia (show PML Proteins).
p19-INK4d inhibits neuroblastoma (show ARHGEF16 Proteins) cell growth, induces differentiation and is hypermethylated and downregulated in MYCN (show MYCN Proteins)-amplified neuroblastomas.
CDKN2D-WDFY2 (show ZFYVE22 Proteins) fusion could be an important molecular signature for understanding and classifying sub-lineages among heterogeneous high-grade serous ovarian carcinomas.
Mutations in CDKN2D is associated with sporadic parathyroid adenoma.
P19(INK4d) expression is a poor prognostic factor in ovarian cancer patients.
The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b (show CDKN2B Proteins)), p16(INK4a), and p19(ARF)) was decreased in E6AP (show ube3a Proteins)(-/-) embryo fibroblasts.
TWIST1 (show TWIST1 Proteins)-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (show TWIST1 Proteins) with regard to senescence inhibition over the time course of breast tumorigenesis.
Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase (show CDK1 Proteins) inhibitor p19Ink4d.
p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging
Cdk4 (show CDK4 Proteins) and Cdk6 (show CDK6 Proteins) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Proteins) in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).
Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase (show CDK1 Proteins) CDK (show CDK4 Proteins) inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues.
We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction
CDK5 (show CDK5 Proteins)-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
, cyclin-dependent kinase 4 inhibitor D
, Cyclin-dependent kinase 4 inhibitor D
, CDK inhibitor p19INK4d
, cell cycle inhibitor, Nur77 associating protein
, cyclin-dependent kinase 4 inhibitor D p19
, inhibitor of cyclin-dependent kinase 4d