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our results validate the assumption that CBX7 (show CBX7 Proteins) is a tumor suppressor of gliomas. Moreover, CBX7 (show CBX7 Proteins) is a potential and novel prognostic biomarker in glioma patients. We also clarified that CBX7 (show CBX7 Proteins) silences CCNE1 via the combination of CCNE1 promoter and the recruitment of HDAC2 (show HDAC2 Proteins).
Our findings suggest that gene copy-number gain and upregulation of CCNE1 occur in ovarian clear cell carcinoma and are associated with a worse clinical outcome, dictating the survival of early-stage patients.
YAP (show YAP1 Proteins)/ TAZ (show TAZ Proteins) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 and CREB (show CREB1 Proteins)
Silencing of CDCA5 (show CDCA5 Proteins) suppresses proliferation of gastric cancer cells by inducing G1-phase arrest via downregulating CCNE1.
Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 and AKT2 (show AKT2 Proteins) Overexpression of Cyclin E1 and AKT (show AKT1 Proteins) isoforms, in addition to mutant TP53 (show TP53 Proteins), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer
Finding suggest that amplification of CCNE1 serves as one mechanism for the development of some serous tubal intraepithelial carcinomas.
Prognostic gene sets based on the 13 genes were developed, and their prognostic values were verified in three independent patient cohorts (n=501). Among them, a signature of CCNE1 and its coexpressed genes was significantly associated with disease progression and validated in the independent cohorts.
Cyclin E1 mRNA and protein expressions were suppressed.
The opposing effects of ORC1 (show ORC1L Proteins) (represor) and CDC6 (show CDC6 Proteins) (gene activator) in controlling the level of Cyclin E ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
High cyclin E expression is associated with breast cancer.
These results demonstrate a repressor role for NFAT1 (show NFAT1 Proteins) in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 (show NFAT1 Proteins) protein in B cell malignancies.
This approach allowed us to determine the identity of cyclin E protein partners, as well as phosphorylation substrates of cyclins E (cyclin (show PCNA Proteins) E1and cyclin E2 (show CCNE2 Proteins))and its associated kinase, Cdk2 (show CDK2 Proteins), in different mouse organs.
inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2 (show CCNA2 Proteins), and E2F1 (show E2F1 Proteins) proteins.
Spermatocytes lacking cyclin E2 (show CCNE2 Proteins) and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages.
NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r (show IGF1R Proteins)/Insr (show INSR Proteins)-Ccnd2 (show CCND2 Proteins)/Ccne1 plays important roles in myogenesis.
Myb (show MYB Proteins) regulates Cyclin E1 expression in normal gastrointestinal tract epithelial cells and is required during intestinal tumorigenesis
These results highlight a new role for E-type cyclins (Ccne1 and Ccne2 (show CCNE2 Proteins)) as important regulators of male meiosis.
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 (show CDK2 Proteins) in hepatocytes inhibits DNA replication and liver regeneration in mice.
Superoxide dismutase (show SOD1 Proteins) induces G1-phase cell cycle arrest by down-regulated expression of Cdk-2 (show CDK2 Proteins) and cyclin-E in sarcoma tumor cells.
Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation.
miR (show MYLIP Proteins)-15/16 and CPEB co-regulate cyclin E1 mRNA.
cyclin E is dynamically and highly conjugated to SUMO2 (show SUMO2 Proteins)/3 on chromatin, independently of Cdk2 (show CDK2 Proteins) activity and origin activation.
These results show that cyclin E destruction at the midblastula transition requires both phosphorylation and nuclear import, as well as proteasomal activity.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 expression.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
, G1/S-specific cyclin-E1
, G1/S-specific cyclin-E1-like
, g1/S-specific cyclin-E1-like
, cyclin Es
, cyclin Et
, cyclin E
, G1/S-specific cyclin-E2
, G1/S-specific cyclin-E3
, cyclin E3