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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016
Low FOXO3A expression is associated with colorectal cancer.
FoxO3a was overexpressed in 64.71% cases of hepatocellular carcinoma (HCC (show FAM126A Proteins)). FoxO3a overexpression was associated with aggressive phenotypes of HCC (show FAM126A Proteins), such as histologic grade, stage, and small vessel invasion. FoxO3a overexpression was also correlated with poor disease-free survival. Downregulation of FoxO3a in a HepG2 cell line inhibited cell proliferation and migration.
stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins.
A better understanding of the mechanisms regulating the FOXO3-FOXM1 (show FOXM1 Proteins) axis, as well as their downstream transcriptional targets and functions, may render these proteins reliable and early diagnostic/prognostic factors as well as crucial therapeutic targets for cancer treatment and importantly, for overcoming chemotherapeutic drug resistance.
the inhibition of miR (show MLXIP Proteins)-9 could induce apoptosis in cervical cancer by targeting FOXO3.
Study in three European populations present experimental evidence for a functional link between common intronic variants in FOXO3 and human longevity.
circRNA-FOXO3 expression was decreased in NSCLC cells and tissue samples. It can inhibit the development of NSCLC cells as a ceRNA through sponging miR (show MLXIP Proteins)-155 and releasing FOXO3 level.
The protein expression levels of several autophagy makers, such as LC3I, LC3II and Beclin-1 (show BECN1 Proteins), were higher in FOXO3 plasmid-transfected AGS (show JAG1 Proteins) cells cultured in an acidic microenvironment than in control cells, while P62 (show GTF2H1 Proteins) protein expression levels were clearly decreased in FOXO3 plasmid-transfected cells compared with control cells.
Study suggests that miR (show MLXIP Proteins)-487a-3p might repress CTLA4 (show CTLA4 Proteins) and FOXO3 by binding to their 3'UTRs and contribute to the development of T1D.
Findings determined that the crucial regions corresponding to the SP1 (show PSG1 Proteins) binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC (show CALR Proteins)), indicating that the interaction between SP1 (show PSG1 Proteins) and FoxO3a may have important implications in CRC (show CALR Proteins) progression.
AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.
These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 Proteins) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (show AKT1 Proteins) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL Proteins), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
data suggested that suppressed Sirt3 (show SIRT3 Proteins)-Foxo3A-Parkin (show PARK2 Proteins) signaling mediated downregulation of mitophagy may play a vital role in the development of diabetic cardiomyopathy.
AMPK (show PRKAA1 Proteins) stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.
Data indicate a key role of FoxO3a/Zdhhc3/GluA1 (show GRIA1 Proteins) axis in the high-fat diet (HFD)-dependent impairment of cognitive function.
Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2 (show CRTC2 Proteins)/AKT (show AKT1 Proteins)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (show TSC22D3 Proteins)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (show KL Proteins) protects Tac (show IL2RA Proteins)-induced oxidative stress by negatively regulating the PI3K/AKT (show AKT1 Proteins) pathway and subsequently enhancing FoxO3a-mediated MnSOD (show SOD2 Proteins) expression.
miR (show MLXIP Proteins)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (show TLR4 Proteins)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
NO/protein kinase (show CDK7 Proteins) G (PKG (show PRKG1 Proteins))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Proteins) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Proteins) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.
FOXO1 (show FOXO1 Proteins), 3, and 4 as well as their upstream regulator, AKT/p-AKT (show AKT1 Proteins), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like