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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. in Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. in Nature neuroscience 2016
expression significantly deceased in degenerated discs
Loss of FOXO3 expression due to O-GlcNAcylation is associated with tumorigenesis.
This study revealed a novel mechanism for prostate cancer metastasis that involves SIRT3/ Wnt/beta-catenin/ FOXO3A signaling to modulate EMT and cell migration.
Study findings present a novel mechanism that controls FOXO3 activation and revealed that SIRT6 is a pivotal regulatory factor in determining liver cancer chemosensitivity. SIRT6 interacts with FOXO3 and this interaction increases FOXO3 ubiquitination and decreases its stability.
FOXO3a activation induces vascular smooth muscle cell apoptosis and extracellular matrix breakdown, in part, because of transcriptional activation of MMP13. FOXO3a activation promotes atherosclerosis and medial degeneration and increases neointima after injury that is partly dependent on MMP13.
The finding suggested that miR-30c-5p might play essential role in NLRP3 inflammasome-modulated cell pyroptosis by targeting FOXO3 in human aortic endothelial cells.
The cardiac regeneration may be promoted by proper control of FOXO1/3 activity. FOXO1 mainly plays a detrimental role in heart while FOXO3's actions are influenced by cell type. [review]
role in autophagy activation and the maintenance of intracellular homeostasis in inflamed odontoblasts
Low FOXO3A expression is associated with colorectal cancer.
FoxO3a was overexpressed in 64.71% cases of hepatocellular carcinoma (HCC). FoxO3a overexpression was associated with aggressive phenotypes of HCC, such as histologic grade, stage, and small vessel invasion. FoxO3a overexpression was also correlated with poor disease-free survival. Downregulation of FoxO3a in a HepG2 cell line inhibited cell proliferation and migration.
stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins.
A better understanding of the mechanisms regulating the FOXO3-FOXM1 axis, as well as their downstream transcriptional targets and functions, may render these proteins reliable and early diagnostic/prognostic factors as well as crucial therapeutic targets for cancer treatment and importantly, for overcoming chemotherapeutic drug resistance.
the inhibition of miR-9 could induce apoptosis in cervical cancer by targeting FOXO3.
Study in three European populations present experimental evidence for a functional link between common intronic variants in FOXO3 and human longevity.
circRNA-FOXO3 expression was decreased in NSCLC cells and tissue samples. It can inhibit the development of NSCLC cells as a ceRNA through sponging miR-155 and releasing FOXO3 level.
The protein expression levels of several autophagy makers, such as LC3I, LC3II and Beclin-1, were higher in FOXO3 plasmid-transfected AGS cells cultured in an acidic microenvironment than in control cells, while P62 protein expression levels were clearly decreased in FOXO3 plasmid-transfected cells compared with control cells.
Study suggests that miR-487a-3p might repress CTLA4 and FOXO3 by binding to their 3'UTRs and contribute to the development of T1D.
Findings determined that the crucial regions corresponding to the SP1 binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC), indicating that the interaction between SP1 and FoxO3a may have important implications in CRC progression.
FOXO3a expression correlated with adverse clinicopathological features, such as lymph node metastasis, perineural invasion and higher Ki-67 proliferation index in triple-negative breast cancers.
human FOXO3B locus encodes a bona fide human gene; unlike FOXO3A, FOXO3B is cytosolically localized in both the presence and absence of active Akt
AIM1 and FOXO3 genes were found to be associated with NBA (number born alive); these genes increase ovarian reproductive capacity and follicle number and decrease gonadotropin levels.
These results indicate that myostatin mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
expression in lumbar intervertebral discs decreased with aging
Foxo3a translocation was not driven by AbetaPP intracellular domain directly but correlated with reduced Akt phosphorylation. betagamma-secretase-mediated AbetaPP processing couples to Foxo3a which could be an early neuronal signaling response in Alzheimer's disease.
Foxo3a physically interacts with Tet2 and regulates the expression of genes related to adult neural stem cells proliferation.
FOXO transcription factors play a salutary role in the protection against the diet-induced fatty liver disease.
data suggested that suppressed Sirt3-Foxo3A-Parkin signaling mediated downregulation of mitophagy may play a vital role in the development of diabetic cardiomyopathy.
AMPK stabilizes FOXO3 and suggest a role in the first initiation step of mitochondrial segregation in muscle cells.
Data indicate a key role of FoxO3a/Zdhhc3/GluA1 axis in the high-fat diet (HFD)-dependent impairment of cognitive function.
Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
The results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes.
Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho protects Tac-induced oxidative stress by negatively regulating the PI3K/AKT pathway and subsequently enhancing FoxO3a-mediated MnSOD expression.
miR-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 inflammasome via promoting the transcription of Bim.
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
FoxOs exacerbate the loss of cancellous bone mass associated with type 1 diabetes.
These results suggest that lack of FXR impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
NO/protein kinase G (PKG)-dependent downregulation of PGC-1 alpha and the ROS detoxification system in endothelial cells are mediated by the PI3K/Akt signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS-induced apoptosis in mammalian cells.
FOXO1, 3, and 4 as well as their upstream regulator, AKT/p-AKT, was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like