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anti-Human RAP1 Antibodies:
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Human Polyclonal RAP1 Primary Antibody for ICC, IF - ABIN4358520
Liu, Safari, OConnor, Chan, Laegeler, Qin, Songyang: PTOP interacts with POT1 and regulates its localization to telomeres. in Nature cell biology 2004
Show all 17 Pubmed References
Human Polyclonal RAP1 Primary Antibody for ICC, IF - ABIN252305
Kim, Davalos, Heo, Rodier, Zou, Beausejour, Kaminker, Yannone, Campisi: Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. in The Journal of cell biology 2008
Show all 4 Pubmed References
Human Monoclonal RAP1 Primary Antibody for WB - ABIN252487
Kim, Beausejour, Davalos, Kaminker, Heo, Campisi: TIN2 mediates functions of TRF2 at human telomeres. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human Monoclonal RAP1 Primary Antibody for WB - ABIN2668781
Bombarde, Boby, Gomez, Frit, Giraud-Panis, Gilson, Salles, Calsou: TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. in The EMBO journal 2010
These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma.
Rap1 telomeric and non-telomeric functions and potential implications in diabetic cardiomyopathy have been discussed. (Review)
the cytoplasmic RAP1 (show RABGEF1 Antibodies)-NF-kappaB (show NFKB1 Antibodies)-BCL2 (show BCL2 Antibodies) axis represents a key pathway to cisplatin resistance in non-small cell lung cancer cells.
Rap1GAP (show RAP1GAP Antibodies) functions as a novel suppressor of epithelial mesenchymal transformation and tumor metastasis in gastric cancer, and loss of Rap1GAP (show RAP1GAP Antibodies) predicts poor prognosis.
The formation of the Rap1 (show RABGEF1 Antibodies)-TRF2 (show TERF2 Antibodies) complex restored DNA unwinding.
Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI.
The Rap1 (show RABGEF1 Antibodies)-RIAM (show APBB1IP Antibodies)-talin axis of integrin activation and blood cell function
Rap1 (show RABGEF1 Antibodies) activation was dependent on PKA and required Src (show SRC Antibodies) family kinases and the Rap1 (show RABGEF1 Antibodies) exchanger C3G (show RAPGEF1 Antibodies).
RAP1 (show RABGEF1 Antibodies) promotes colorectal cell migration through the regulation of Vimentin (show VIM Antibodies) and RAP1 (show RABGEF1 Antibodies) may act as a potential target for the diagnosis and therapy of CRC (show CALR Antibodies).
Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Rap1 activation was dependent on PKA and required Src (show SRC Antibodies) family kinases and the Rap1 exchanger C3G (show RAPGEF1 Antibodies).
Collectively the observations uncover a requirement for Rap1 in maintenance of lens epithelial phenotype and morphogenesis.
our results indicate that Rasa3 catalytic activity controls Rap1 activation and integrin signaling during megakaryocyte differentiation in mouse.
RASA3, inhibits platelet activation and provides a link between P2Y12 and activation of the RAP1 signaling pathway.
we summarize recent developments in understanding the small G protein (show RAC2 Antibodies) RAP1 and its effector RASIP1 (show RASIP1 Antibodies) as critical mediators of endothelial junction stabilization.
Molecular investigation revealed that deletion of RAP1 reduced upregulation of inflammatory cytokine (IL1A (show IL1A Antibodies)), finely regulated the expression of angiogenic factor (VEGF (show VEGFA Antibodies)), and antiangiogenic factor (PEDF (show SERPINF1 Antibodies)), following injury for better corneal recovery.
Cdk5-mediated serine-phosphorylation of C3G may control Rap1 stability and activity
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
, TERF2-interacting telomeric protein 1
, TRF2-interacting telomeric RAP1 protein
, TRF2-interacting telomeric protein 1
, dopamine receptor interacting protein 5
, dopamine receptor-interacting protein 5
, repressor/activator protein 1 homolog
, telomeric repeat-binding factor 2-interacting protein 1
, TRF2-interacting telomeric protein Rap1