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Full name:: Ring-Box 1, E3 Ubiquitin Protein Ligase Proteins (RBX1)

On www.antibodies-online.com are 8 Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) Proteins from 4 different suppliers available. Additionally we are shipping RBX1 Antibodies (73) and and many more products for this protein. A total of 84 RBX1 products are currently listed.

Synonyms:: 1500002P15Rik, AA517855, anon-EST:Posey65, ATRBX1, BA554C12.1, BEST:CK01110, CG16982, CK01110, Dmel\CG16982, dRbx1, dRoc1, dRoc1a, EG:115C2.11, F7C8.160, F7C8_160, hop21, HRT1, im:7137515, Rbx1, Rbx1/Roc, REGULATOR OF CULLINS-1, RING-box 1, RNF75, Roc, ROC1, Roc1alpha, zgc:136444

list all proteins	Gene Name	GeneID	UniProt
	RBX1	9978	P62877
	RBX1	56438	P62878
Rat RBX1	RBX1	300084
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RBX1 Proteins (RBX1) by Origin

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Top referenced RBX1 Proteins

Human RBX1 Protein expressed in Wheat germ - ABIN1317671 : Mallampalli, Glasser, Coon, Chen: Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)

More Proteins for RBX1 Interaction Partners

Human Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

RBX-1 overexpression in bladder UCC is associated with high tumor grade and advanced stage and represents biological potential of invasiveness and aggressive disease.
The crystal structure of a pentameric CRL2 (show CRLF2 Proteins)(VHL (show VHL Proteins)) complex, composed of Cul2 (show CUL2 Proteins), Rbx1, Elongin B (show TCEB2 Proteins), Elongin C (show TCEB1 Proteins), and pVHL (show VHL Proteins) reveals how Rbx1 interacts with Cullin 2 (show CUL2 Proteins).
Study demonstrated that ROC1 was overexpressed in esophageal squamous cell carcinomas, which was positive associated with poor prognosis of esophageal cancer patients.
p97 (show EIF4G2 Proteins) negatively regulates NRF2 (show GABPA Proteins) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA Proteins) from the KEAP1 (show KEAP1 Proteins)-CUL3 (show CUL3 Proteins) E3 complex.
Regulation of substrate ubiquitination and polyubiquitination takes place through Rbx1 rotations.
High RBX1 expression was related to poor tumor differentiation, advanced TNM (show ODZ1 Proteins) stage, and lymph node metastasis in non-small cell lung cancer.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
ROC1 (show RIT1 Proteins) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 Proteins)/DEPTOR (show DEPTOR Proteins) pathway.
Nedd8 (show NEDD8 Proteins)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 Proteins)-Rbx1 as wild-type Nedd8 (show NEDD8 Proteins).
RBX1 E3 ubiquitin protein expression responsible with multiple genetic mechanism in the development of head and neck cancer.

Mouse (Murine) Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

Downregulation of Rbx1 caused accumulation of Emi1.
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B Proteins) accumulation during the early stage of embryonic development

Cow (Bovine) Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

The SCF (show KITLG Proteins)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Proteins).

Arabidopsis thaliana Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).

Caenorhabditis elegans (C. elegans) Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Proteins) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Proteins)- and RBX-1-CUL-2 (show CUL2 Proteins)-based complexes.

Fruit Fly (Drosophila melanogaster) Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1) interaction partners

BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF (show KITLG Proteins) E3 ubiquitin ligase (show MUL1 Proteins).
Roc1b, Roc1a and Roc2 (show RIT2 Proteins) proteins play nonredundant roles during development

RBX1 Protein Profile

Protein Summary

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.

Alternative names and synonyms associated with RBX1

ring-box 1 (RBX1)
ring-box 1 (Rbx1)
ring-box 1, E3 ubiquitin protein ligase (rbx1)
RING-box 1 (RBX1)
RING-box protein 1 (MGG_08844)
RING-box protein 1a (LOC9308017)
ring-box 1 (rbx1)
RING-box protein 1 (rbx-1)
Regulator of cullins 1a (Roc1a)

1500002P15Rik protein
AA517855 protein
anon-EST:Posey65 protein
ATRBX1 protein
BA554C12.1 protein
BEST:CK01110 protein
CG16982 protein
CK01110 protein
Dmel\CG16982 protein
dRbx1 protein
dRoc1 protein
dRoc1a protein
EG:115C2.11 protein
F7C8.160 protein
F7C8_160 protein
hop21 protein
HRT1 protein
im:7137515 protein
Rbx1 protein
Rbx1/Roc protein
REGULATOR OF CULLINS-1 protein
RING-box 1 protein
RNF75 protein
Roc protein
ROC1 protein
Roc1alpha protein
zgc:136444 protein

Protein level used designations for RBX1

, , , , , , , , , , , , , , , , , , , E3 ubiquitin-protein ligase RBX1 RING box protein 1 RING finger protein 75 RING-box protein 1 ZYP protein regulator of cullins 1 ring-box protein 1 ring-box 1 hyperosmotic protein 21 sHOP21 CG16982 gene product from transcript CG16982-RC CG16982-PA CG16982-PC CG16982-PD Regulator of cullins 1a Roc1a-PA Roc1a-PC Roc1a-PD dRbx1 regulator of cullins 1a

GENE ID	SPECIES
9978	Homo sapiens
56438	Mus musculus
300084	Rattus norvegicus
418001	Gallus gallus
449846	Danio rerio
458860	Pan troglodytes
474494	Canis lupus familiaris
518880	Bos taurus
832179	Arabidopsis thaliana
2679830	Magnaporthe oryzae 70-15
9308017	Arabidopsis lyrata subsp. lyrata
100528272	Ictalurus punctatus
179358	Caenorhabditis elegans
100136424	Salmo salar
31014	Drosophila melanogaster

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Show all Ring-Box 1, E3 Ubiquitin Protein Ligase Proteins (RBX1) with Pubmed References