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Human RBX1 Protein expressed in Wheat germ - ABIN1317671
Mallampalli, Glasser, Coon, Chen: Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. in Cell cycle (Georgetown, Tex.) 2013
SESN2 (show SESN2 Proteins) is critical to protect cells against detrimental effect of mitochondrial damage and RBX1 is a negative regulator of SESN2 (show SESN2 Proteins) which hampers its stabilization.
RBX-1 overexpression in bladder UCC is associated with high tumor grade and advanced stage and represents biological potential of invasiveness and aggressive disease.
The crystal structure of a pentameric CRL2 (show CRLF2 Proteins)(VHL (show VHL Proteins)) complex, composed of Cul2 (show CUL2 Proteins), Rbx1, Elongin B (show TCEB2 Proteins), Elongin C (show TCEB1 Proteins), and pVHL (show VHL Proteins) reveals how Rbx1 interacts with Cullin 2 (show CUL2 Proteins).
Study demonstrated that ROC1 was overexpressed in esophageal squamous cell carcinomas, which was positive associated with poor prognosis of esophageal cancer patients.
p97 (show EIF4G2 Proteins) negatively regulates NRF2 (show GABPA Proteins) through the canonical pathway by extracting ubiquitylated NRF2 (show GABPA Proteins) from the KEAP1 (show KEAP1 Proteins)-CUL3 (show CUL3 Proteins) E3 complex.
Regulation of substrate ubiquitination and polyubiquitination takes place through Rbx1 rotations.
High RBX1 expression was related to poor tumor differentiation, advanced TNM (show ODZ1 Proteins) stage, and lymph node metastasis in non-small cell lung cancer.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
ROC1 (show RIT1 Proteins) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 Proteins)/DEPTOR (show DEPTOR Proteins) pathway.
Nedd8 (show NEDD8 Proteins)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 Proteins)-Rbx1 as wild-type Nedd8 (show NEDD8 Proteins).
Downregulation of Rbx1 caused accumulation of Emi1.
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B Proteins) accumulation during the early stage of embryonic development
The SCF (show KITLG Proteins)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Proteins).
The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Proteins) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Proteins)- and RBX-1-CUL-2 (show CUL2 Proteins)-based complexes.
BRWD3 functions as a Damage-specific DNA binding protein 1 (DDB1)- and CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-dependent binding of dCRY to CUL4-ROC1-DDB1-BRWD3, inducing ubiquitylation of dCRY
Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF (show KITLG Proteins) E3 ubiquitin ligase (show MUL1 Proteins).
Roc1b, Roc1a and Roc2 (show RIT2 Proteins) proteins play nonredundant roles during development
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
E3 ubiquitin-protein ligase RBX1
, RING box protein 1
, RING finger protein 75
, RING-box protein 1
, ZYP protein
, regulator of cullins 1
, ring-box protein 1
, ring-box 1
, hyperosmotic protein 21
, CG16982 gene product from transcript CG16982-RC
, Regulator of cullins 1a
, regulator of cullins 1a