Topoisomerase II alpha Proteins
4 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Proteins from 3 manufacturers are available on www.antibodies-online.com.
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Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1-1531) protein (His tag) Protein
Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1-1528) protein (His tag) Protein
Topoisomerase (DNA) II alpha 170kDa (TOP2A) (AA 1435-1531) protein (GST tag) Protein
Topoisomerase (DNA) II alpha 170kDa (TOP2A) Protein Protein
Topoisomerase II alpha (TOP2A) Protein Profile
Protein Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)
- DNA topoisomerase II alpha (TOP2A) antibody
- DNA topoisomerase II, alpha isozyme (Bm1_08705) antibody
- topoisomerase (DNA) II alpha (Top2a) antibody
- DNA topoisomerase II alpha (Top2a) antibody
- topoisomerase (DNA) II alpha (TOP2A) antibody
- Zincin-like metalloproteases family protein (AT5G10540) antibody
- DNA topoisomerase II alpha (top2a) antibody
- F12B17.110 antibody
- F12B17_110 antibody
- fc08c07 antibody
- thimet metalloendopeptidase 2 antibody
- TOP-2 antibody
- TOP2 antibody
- TOP2A antibody
- TP2A antibody
- wu:fc08c07 antibody
Protein level used designations for TOP2A
DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase 2-alpha , DNA topoisomerase II, 170 kD , DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , topoisomerase (DNA) 2 alpha , DNA topoisomeraseII_alpha , topoisomerase (DNA) II alpha , Thimet metalloendopeptidase 2 , Zincin-like metalloproteases family protein 2 , topoisomerase 2
GENE ID | SPECIES |
---|---|
7153 | Homo sapiens |
700707 | Macaca mulatta |
6096668 | Brugia malayi |
21973 | Mus musculus |
360243 | Rattus norvegicus |
395570 | Gallus gallus |
396917 | Sus scrofa |
480525 | Canis lupus familiaris |
100689304 | Cricetulus griseus |
787696 | Bos taurus |
100730168 | Cavia porcellus |
830919 | Arabidopsis thaliana |
323733 | Danio rerio |
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