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these results suggest the MIEN1 promoter has a short interspersed nuclear Alu element region that is hypermethylated in normal cells leading to repression of the gene; in cancer, the hypomethylation of a part of this repeat, in addition to the binding of USF, results in MIEN1 expression
Data show that migration and invasion enhancer 1 (MIEN1) plays an essential role in maintaining the plasticity of the dynamic membrane-associated actin cytoskeleton, which leads to an increase in cell motility, suggesting targeting MIEN1 might represent a promising means to prevent breast tumor metastasis.
Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells.
indicate that MIEN1 overexpression may facilitate migration and invasion in breast cancer
In conclusion, this study revealed that miR (show MLXIP Proteins)-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB (show NFKB1 Proteins)/MMP-9 (show MMP9 Proteins)/VEGF (show VEGFA Proteins) pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment.
MIEN1, a novel interactor of Annexin A2 (show ANXA2 Proteins), promotes tumor cell migration by enhancing AnxA2 (show ANXA2 Proteins) cell surface expression.
MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells.
C35 might serve as a biomarker or therapeutic target for management of colorectal cancer.
While MIEN1 is a direct target of miR (show MLXIP Proteins)-940, miR (show MLXIP Proteins)-940 alters MIEN1 RNA.
results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells.
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).
hypothetical protein LOC548750
, hypothetical protein LOC100049740
, HBV X-transactivated gene 4 protein
, HBV XAg-transactivated protein 4
, protein C17orf37
, protein C17orf37 homolog