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Browse our Glutaredoxin 5 Proteins (GLRX5)

Full name:: Glutaredoxin 5 Proteins (GLRX5)

On www.antibodies-online.com are 9 Glutaredoxin 5 (GLRX5) Proteins from 5 different suppliers available. Additionally we are shipping Glutaredoxin 5 Antibodies (38) and Glutaredoxin 5 Kits (1) and many more products for this protein. A total of 50 Glutaredoxin 5 products are currently listed.

Synonyms:: 2310004O13Rik, 2900070E19Rik, AU020725, C14orf87, FLB4739, GRX5, id:ibd5119, PR01238, PRO1238, RGD1308383, wu:fa09g08, zgc:73343

list all proteins	Gene Name	GeneID	UniProt
	GLRX5	51218	Q86SX6
Rat GLRX5	GLRX5	362776
	GLRX5	73046	Q80Y14
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Glutaredoxin 5 Proteins (GLRX5) by Origin

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Relevant Pathways for Glutaredoxin 5 Proteins

Cell RedoxHomeostasis

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Human Glutaredoxin 5 (GLRX5) interaction partners

GLRX5 rs1007814 showed a statistically marginally significant difference between cases and controls in genotype frequency (case/control: CC 1:6; CT 112:78; TT 752:505, P=0.049361), but no significant differences in allele distribution [odds ratio (OR)=0.852805]In men, we found a minor difference in the genotype frequency (case/control: CC 0:3; CT 72:36; TT 411:280, P=0.037370) and not in allele distribution (OR=1.142857)
Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.
crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
No GLRX5 mutations were found among sixty CSA probands examined
Mutations in GLRX5 is associated with sideroblastic-like microcytic anemia and iron overload

Mouse (Murine) Glutaredoxin 5 (GLRX5) interaction partners

Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin secretion, increase of reactive oxygen species (ROS) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.
Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS production, cardiolipin oxidation, caspase activity, Fe-S cluster formation, and MnSOD activity.

Zebrafish Glutaredoxin 5 (GLRX5) interaction partners

the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly

Glutaredoxin 5 (GLRX5) Protein Profile

Protein Summary

This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.

Alternative names and synonyms associated with Glutaredoxin 5 (GLRX5)

glutaredoxin 5 L homeolog (glrx5.L)
glutaredoxin 5 (GLRX5)
glutaredoxin 5 (Glrx5)
glutaredoxin 5 homolog (S. cerevisiae) (glrx5)

2310004O13Rik protein
2900070E19Rik protein
AU020725 protein
C14orf87 protein
FLB4739 protein
GRX5 protein
id:ibd5119 protein
PR01238 protein
PRO1238 protein
RGD1308383 protein
wu:fa09g08 protein
zgc:73343 protein

Protein level used designations for Glutaredoxin 5 Proteins (GLRX5)

glutaredoxin 5 homolog , glutaredoxin-related protein 5, mitochondrial , monothiol glutaredoxin-5 , shiraz , shz

GENE ID	SPECIES
734675	Xenopus laevis
51218	Homo sapiens
505935	Bos taurus
362776	Rattus norvegicus
73046	Mus musculus
406294	Danio rerio

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