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Human Polyclonal TXN2 Primary Antibody for ICC, IF - ABIN4359198
Dammeyer, Arnér: Human Protein Atlas of redox systems - what can be learnt? in Biochimica et biophysica acta 2010
Human Polyclonal TXN2 Primary Antibody for WB - ABIN4247454
Dunn, Simpson, Prosser, Lecce, Yuen, Buckle, Sieveking, Vanags, Lim, Chow, Lam, Clayton, Bao, Davies, Stadler, Celermajer, Stocker, Bursill, Cooke, Ng: A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis. in Diabetes 2014
Prx3 (show PRDX3 Antibodies) and Trx2 comprise an adaptive system to sense changes in atmospheric oxygen tension and influence cellular injury responses through both detoxification of mitochondrial oxidants and regulation of mitochondrial redox-dependent signaling
Trx2 overexpression failed to attenuate hypoxia-induced human pulmonary arterial smooth muscle cells proliferation in vitro or hypoxia-induced Pulmonary hypertension in vivo.
study demonstrated that miR (show MLXIP Antibodies)-27a and -b, which are widely expressed in host cells, suppress SNAP25 (show SNAP25 Antibodies) and TXN2 expression through posttranscriptional gene silencing.
No evidence that SNPs in TRX2 have effects, but the rs4485648 polymorphism of the TrxR2 (show TXNRD2 Antibodies) gene might exert an independent effect on the development of Diabetic retinopathy.
Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus by promoting the nuclear translocation of the p65 (show GORASP1 Antibodies) subunit of NF-kappaB (show NFKB1 Antibodies).
The Grx2 (show GRX2 Antibodies) system could help to keep Trx2/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling.
CERKL (show CERKL Antibodies) interacts with TRX2 and plays a novel key role in the regulation of the TRX2 antioxidant pathway.
TGF-beta (show TGFB1 Antibodies)-mediated expression of the epithelial-mesenchymal transition marker fibronectin (show FN1 Antibodies) was inhibited not only by chemicals that interfere with reactive oxygen species signaling but also by exogenously expressed mitochondrial thioredoxin.
We showed that overexpression of TRXs reduced cell death; TRX2 was expressed in the mitochondria, while TRX1 (show MLL Antibodies) was expressed in the cytoplasm.
knockdown of TRX-1 (show MLL Antibodies) or TRX-2 sensitizes cells to CYP2E1 (show CYP2E1 Antibodies)-induced oxidant stress partially via ASK-1 (show MAP3K5 Antibodies) and JNK1 (show MAPK8 Antibodies) signaling pathways. Both TRX-1 (show MLL Antibodies) and TRX-2 are important for defense against CYP2E1 (show CYP2E1 Antibodies)-induced oxidative stress.
This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila.
gene for thioredoxin (DmTrx-2) was cloned and expressed, and the protein characterized
Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor (show GPR37 Antibodies) - and poly-glutamine (show GFPT2 Antibodies)-induced neurotoxicity
Trx-2 affects lifespan in Drosophila. Mutants have a decreased lifespan.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1 (show ISL1 Antibodies)/2 and FoxP1 (show FOXP1 Antibodies) and the strong ventral signal colocalizing with Isl1 (show ISL1 Antibodies)/2 was observed in all rostrocaudal segments of the spinal cord.
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
The SirT1 (show SIRT1 Antibodies) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Antibodies), catalase (show CAT Antibodies), peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2 (show TXNRD2 Antibodies), and uncoupling protein 2 (show UCP2 Antibodies).
This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Both thioredoxin 2 and glutaredoxin 2 (show GRX2 Antibodies) contribute to the reduction of the mitochondrial 2-Cys (show DNAJC5 Antibodies) peroxiredoxin Prx3 (show PRDX3 Antibodies).
Data show that Nrf2 (show NFE2L2 Antibodies) activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions.
the rapid E2-mediated activation of the Txn (show TXN Antibodies) pathway is an important step in the response of the mammalian uterus to estrogen.
Trx2 is an endogenous regulator of the mitochondrial permeability transition.
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
, thioredoxin, mitochondrial
, thioredoxin 2
, Thioredoxin 2
, thioredoxin nuclear gene encoding mitochondrial protein