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Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP (show BGLAP Proteins) through the formation of an intramolecular disulfide bond (Cys (show DNAJC5 Proteins)(318)-Cys (show DNAJC5 Proteins)(326)), known to act as a redox switch that precludes the allosteric activation of bGP (show BGLAP Proteins) by AMP (show APRT Proteins).
disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP (show APRT Proteins) without affecting its activation by phosphorylation. This unique regulatory feature of bGP (show BGLAP Proteins) sheds new light on the isoform-specific regulation of glycogen (show GYS1 Proteins) phosphorylase and glycogen (show GYS1 Proteins) metabolism.
the bGP (show BGLAP Proteins) structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP (show APRT Proteins).
GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome.
H-FABP (show FABP3 Proteins) and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome
Brain-type glycogen (show GYS1 Proteins) phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor.
The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.
brain glycogen phosphorylase
, phosphorylase, glycogen; brain
, glycogen phosphorylase, brain form
, glycogen phosphorylase B