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Full name:: phosphorylase, Glycogen, Brain Proteins (GPBB)

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Synonyms:: GLYPHOA, GPBB

list all proteins	Gene Name	GeneID	UniProt
	GPBB	110078	Q8CI94
	GPBB	5834	P11216
Rat GPBB	GPBB	25739	P53534
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Relevant Pathways for phosphorylase, Glycogen, Brain Proteins

Cellular Glucan Metabolic Process

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Human phosphorylase, Glycogen, Brain (GPBB) interaction partners

PYGB siRNA exerted an inhibitory effect on the cell viability of the human osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling pathway, highlighting novel potential therapeutic methods for treating osteosarcoma.
Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP through the formation of an intramolecular disulfide bond (Cys(318)-Cys(326)), known to act as a redox switch that precludes the allosteric activation of bGP by AMP.
disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affecting its activation by phosphorylation. This unique regulatory feature of bGP sheds new light on the isoform-specific regulation of glycogen phosphorylase and glycogen metabolism.
the bGP structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP.
GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome.
H-FABP and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome
Significant increase in plasma glycoprotein BB in patients with hypertrophic cardiomyopathy.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
Brain-type glycogen phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor.

phosphorylase, Glycogen, Brain (GPBB) Protein Profile

Protein Summary

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

Alternative names and synonyms associated with phosphorylase, Glycogen, Brain (GPBB)

glycogen phosphorylase B (PYGB)
phosphorylase, glycogen; brain (pygb)
phosphorylase, glycogen; brain (PYGB)
brain glycogen phosphorylase (Pygb)
glycogen phosphorylase B (Pygb)
glycogen phosphorylase B (pygb)
phosphorylase, glycogen; brain S homeolog (pygb.S)

GLYPHOA protein
GPBB protein

Protein level used designations for GPBB

glycogen phosphorylase, brain form , brain glycogen phosphorylase , glycogen phosphorylase B , phosphorylase, glycogen; brain

GENE ID	SPECIES
100173733	Pongo abelii
403051	Danio rerio
469908	Pan troglodytes
421248	Gallus gallus
554325	Ovis aries
505560	Bos taurus
110078	Mus musculus
5834	Homo sapiens
25739	Rattus norvegicus
477003	Canis lupus familiaris
100380295	Salmo salar
100037229	Xenopus laevis
100730114	Cavia porcellus

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