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anti-Human ABCA1 Antibodies:
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Chicken Polyclonal ABCA1 Primary Antibody for ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. in Journal of lipid research 2004
Show all 259 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. in The Journal of biological chemistry 2002
Show all 13 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, IHC (fro) - ABIN268848
Murthy, Born, Mathur, Field: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. in Journal of lipid research 2002
Show all 13 Pubmed References
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. in PLoS ONE 2009
Show all 7 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3043773
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
Show all 5 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3044206
Chen: Effects of Chinese Herbal Compound "Xuemai Ning"on Rabbit Atherosclerosis Model and Expression of ABCA1. in International journal of biomedical science : IJBS 2013
Show all 5 Pubmed References
Human Monoclonal ABCA1 Primary Antibody for CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. in American journal of physiology. Renal physiology 2009
Show all 5 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, FACS - ABIN446266
Ingram, Crowther, Little, Freeman, Harliwong, Veleva, Hassall, Remke, Taylor, Hallahan: ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. in Experimental hematology & oncology 2013
Human Polyclonal ABCA1 Primary Antibody for IF (p), IHC (p) - ABIN732188
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for FACS, IF - ABIN2477218
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. in Pflügers Archiv : European journal of physiology 2007
Hsp27 (show HSPB1 Antibodies) may up-regulate the expression of ABCA1 and promotes cholesterol efflux through activation of the PI3K (show PIK3CA Antibodies)/PKCzeta (show PRKCZ Antibodies)/Sp1 (show PSG1 Antibodies) signal pathway in THP-1 (show GLI2 Antibodies) macrophage-derived foam cells
the present study revealed that overexpression of GLP1R (show GLP1R Antibodies) significantly reduces proliferation, migration and cytokine release in ASM (show SMPD1 Antibodies) cells from COPD (show ARCN1 Antibodies) patients; this involved a significant increase in ABCA1 expression levels. This provided evidence to suggest that GLP1R (show GLP1R Antibodies) may be a potential therapeutic target for the treatment of COPD (show ARCN1 Antibodies).
Abnormal expression of ABCA1 may be associated with the dysregulation of placental lipid metabolism and the occurrence or development of spontaneous deliveries.
apoA-II (show APOA2 Antibodies) enhanced ABCA1-mediated cholesterol efflux
Cholesterol efflux from THP-1 (show GLI2 Antibodies) macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression.
identified HuR (show ELAVL1 Antibodies) as a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL (show HSD11B1 Antibodies) cholesterol levels.
Hepatic ABCA1 deficiency results in increased hepatic triglyceride and ANGPTL3 (show ANGPTL3 Antibodies) secretion, potentially underlying the elevated plasma triglyceride levels in Tangier disease patients.
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (show APOA1 Antibodies) and lipids metabolically segregate.
Hepatic free cholesterol content was significantly increased in NASH (show SAMSN1 Antibodies) as compared to non-NASH (show SAMSN1 Antibodies) subjects, while ABCA1 and ABCG1 (show ABCG1 Antibodies) protein levels significantly decreased with NASH (show SAMSN1 Antibodies) and fibrosis progression. The relative expression of miR (show MLXIP Antibodies)-33a and miR (show MLXIP Antibodies)-144 correlated inversely with ABCA1 but not with ABCG1 (show ABCG1 Antibodies) protein levels. miR (show MLXIP Antibodies)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (show SAMSN1 Antibodies) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (show ABCB6 Antibodies) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
our results highlight the importance of the LXR (show NR1H3 Antibodies)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Antibodies) or ABCG1 (show ABCG1 Antibodies) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Antibodies) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
(1) ABCA1 maintains optimal hepatocyte PM FC, through intracellular FC trafficking, for efficient insulin (show INS Antibodies) signaling; and (2) hepatocyte ABCA1 deletion produces a form of selective insulin (show INS Antibodies) resistance so that lipogenesis is suppressed but glucose metabolism remains normal
demonstrates behavior deficits caused by Abca1 deletion in APP (show APP Antibodies)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (show APOE Antibodies)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (show SCARB1 Antibodies) within RCT (show FOXE3 Antibodies).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (show CAV1 Antibodies) enhances internalization and degradation of ABCA1 by its association with ABCA1
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (show PCSK9 Antibodies) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (show APOA1 Antibodies)/ABCA1-mediated cholesterol efflux without STAT3 (show STAT3 Antibodies) activation can reduce proinflammatory cytokine expression in macrophages.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1