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Human Polyclonal CCL3L1 Primary Antibody for ELISA - ABIN449836
McKinney, Merriman, Chapman, Gow, Harrison, Highton, Jones, McLean, ODonnell, Pokorny, Spellerberg, Stamp, Willis, Steer, Merriman: Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. in Annals of the rheumatic diseases 2008
Characterization of CCL3L1 CNVs with droplet digital PCR methodology highlighted specific CN genotypes in a French family sample. A copy number polymorphism of a rheumatoid arthritis (RA) candidate gene was quantified, and its significant association with RA was revealed in a Tunisian sample.
Studied copy number variation of the CCL3L1 gene in contributing to the host variation in susceptibility and response to HIV infection by analyzing a sub-Saharan African cohort.
no evidence for an influence of variation in genes coding for MIP-1alpha or CCR5 individually or together in susceptibility to clinically active TB
Studies indicate beta-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4) for copy number variation in disease association.
The number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs nor with IVIG resistance in Korean KD patients.
The results do not support involvement of the CCL3L1 copy number variants in rheumatoid arthritis susceptibility.
The data show no statistically significant association of MIP-1alpha protein levels with copy number. However, there was a significant correlation between copy number and CCL3L1:CCL3 mRNA ratio.
Examined a Zimbabwean study population for an association of CCL3L CNV with HIV status, progression and survival. Found no association between four CCL3L CNV strata and HIV status , CD4 T-cell count, viral load , or CCL3 protein levels.
Studied the copy number variation of the chemokine gene CCL3L1 with susceptibility to malaria. We identified a high level of copy number haplotype diversity and find some evidence for an association of low CCL3L1 copy number with protection from anaemia.
liver transplant recipients with high copy number of CCL3L1 gene had a significant higher risk of acute rejection
Copy number of CCL3L1 may influence asthma risk by modulating IL-10 expression
The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis.
CCL3L1 copy number variation has a role in susceptibility to HIV-1 infection
Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors.
The CCL3L1-CCR5 axis may play an important role in Kawasaki Disease pathogenesis. In addition to clinical and laboratory parameters, genetic markers may also predict risk of CAL and resistance to IVIG.
Studies indicate that complete phenotypic impact requires dissecting the combinatorial genomic complexity posed by various proportions of distinct CCL3L and CCL4L genes among individuals.
The association between gene dosage in the gene encoding FCGR3B with the risk of developing autoimmune diseases and whether the observed associations are modified by the gene dosage in CCL3L1 are reported.
higher level of expression at systemic level is associated with protection from HIV-1 infection in women from Benin
Lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C. Copy number variation of host genes represents a novel class of genetic diversity associated with viral hepatitis.
A high CCL3L1 copy number (>2) was associated with an 80% reduced risk of acquiring HIV infection.
Copy numbers of CCL3L1 in rhesus macaque trios (sire, dam, and offspring) were consistent with Mendelian inheritance
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals\; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more telomeric full-length gene.
C-C motif chemokine 3-like 1
, G0/G1 switch regulatory protein 19-2
, PAT 464.2
, small inducible cytokine A3-like 1
, small-inducible cytokine A3-like 1
, tonsillar lymphocyte LD78 beta protein
, chemokine ligand 3-like 1
, macrophage inflamatory protein 1 alpha
, chemokine (C-C motif) ligand 3-like 1