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Characterization of CCL3L1 CNVs with droplet digital PCR methodology highlighted specific CN genotypes in a French family sample. A copy number polymorphism of a rheumatoid arthritis (RA) candidate gene was quantified, and its significant association with RA was revealed in a Tunisian sample.
Studied copy number variation of the CCL3L1 gene in contributing to the host variation in susceptibility and response to HIV infection by analyzing a sub-Saharan African cohort.
no evidence for an influence of variation in genes coding for MIP-1alpha or CCR5 individually or together in susceptibility to clinically active TB
Studies indicate beta-defensins (DEFB4 (show DEFB104A Proteins), DEFB103 (show DEFB103A Proteins), DEFB104 (show DEFB104A Proteins)), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor (show FCGR1A Proteins) 3B (FCGR3B (show CD16 Proteins)), and complement component C4 (C4) for copy number variation in disease association.
The number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs (show CA8 Proteins) nor with IVIG resistance in Korean KD patients.
The results do not support involvement of the CCL3L1 copy number variants in rheumatoid arthritis susceptibility.
The data show no statistically significant association of MIP-1alpha (show CCL3 Proteins) protein levels with copy number. However, there was a significant correlation between copy number and CCL3L1:CCL3 (show CCL3 Proteins) mRNA ratio.
Examined a Zimbabwean study population for an association of CCL3L CNV with HIV status, progression and survival. Found no association between four CCL3L CNV strata and HIV status , CD4 (show CD4 Proteins) T-cell count, viral load , or CCL3 (show CCL3 Proteins) protein levels.
Studied the copy number variation of the chemokine (show CCL1 Proteins) gene CCL3L1 with susceptibility to malaria. We identified a high level of copy number haplotype diversity and find some evidence for an association of low CCL3L1 copy number with protection from anaemia.
liver transplant recipients with high copy number of CCL3L1 gene had a significant higher risk of acute rejection
Copy numbers of CCL3L1 in rhesus macaque trios (sire, dam, and offspring) were consistent with Mendelian inheritance
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals\; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more telomeric full-length gene.
C-C motif chemokine 3-like 1
, G0/G1 switch regulatory protein 19-2
, PAT 464.2
, small inducible cytokine A3-like 1
, small-inducible cytokine A3-like 1
, tonsillar lymphocyte LD78 beta protein
, chemokine ligand 3-like 1
, macrophage inflamatory protein 1 alpha
, chemokine (C-C motif) ligand 3-like 1