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Human Polyclonal CDC73 Primary Antibody for IP, WB - ABIN152320
Yart, Gstaiger, Wirbelauer, Pecnik, Anastasiou, Hess, Krek: The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. in Molecular and cellular biology 2005
Show all 10 Pubmed References
Human Polyclonal CDC73 Primary Antibody for IP, WB - ABIN152321
Hoffmans, Basler: BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. in Mechanisms of development 2006
Pathogenic germline CDC73 variants were identified in primary hyperparathyroidism patients, with (suspected) hyperparathyroidism-jaw tumor syndrome familial isolated primary hyperparathyroidism and apparently sporadic parathyroid carcinoma
Data suggest that down-regulated parafibromin (HRPT2; CDC73) expression might be closely linked to colorectal carcinogenesis and cancer differentiation.
A novel deletion of exons 4 to 10 of CDC73 was detected by CNV analysis in the three affecteds. A novel insertion in the 5'UTR (show UTS2R Antibodies) (c.-4_-11insG) that co-segregated with the deletion was identified.
Germline mutation of HRPT2 is associated with parathyroid carcinoma.
parafibromin downregulation might promote the pathogenesis, dedifferentiation and metastasis of ovarian cancers possibly by suppressing aggressive phenotypes, such as proliferation, cell cycle, apoptosis, migration and invasion.
We suggest that parafibromin may be a possible prognostic and predictive parameter for breast carcinomas
These findings suggest that downregulated expression of parafibromin protein plays an important role in the pathogenesis, differentiation, and metastasis of head and neck squamous cell carcinomas
Parafibromin interacted with JAK1 (show JAK1 Antibodies)/2, promoted the interactions of JAK1 (show JAK1 Antibodies)-JAK2 (show JAK2 Antibodies) and JAK1 (show JAK1 Antibodies)/2-STAT1 (show STAT1 Antibodies), and promoted tyrosine phosphorylation of STAT1 (show STAT1 Antibodies) by JAKs after IFN-gamma (show IFNG Antibodies) stimulation.
targets and destabilizes p53 (show TP53 Antibodies) mRNA to control p53 (show TP53 Antibodies)-mediated apoptosis
Data report a novel mutation in the CDC73 gene that may underlie HPT-JT syndrome.
Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice.
These results aid in our understanding of the role parafibromin plays within transcriptional regulation, terminal differentiation, and bone homeostasis
Data indicate that isruption of the MLL (show MLL Antibodies)-PAFc subunit, Cdc73 (Hrpt2) interaction selectively inhibits the proliferation of MLL (show MLL Antibodies) leukemic cells.
Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation
Expression of Hrpt2 and parafibromin is pivotal in mammalian development and survival in adults and that these functions are likely mediated by the transcriptional regulation of growth factors.
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
Paf1/RNA polymerase II complex component
, cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, cell division cycle protein 73 homolog
, hyperparathyroidism 2 protein
, Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
, hyperparathyroidism 2 homolog
, hyperparathyroidism 2 protein homolog
, hyperparathyroidism 2 (with jaw tumor)
, hyperparathyroidism 2 with jaw tumor protein
, cell division cycle 73 S homeolog