Browse our Fibronectin 1 Proteins (FN1)

Zebrafish Fibronectin 1 (FN1) interaction partners

1. Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.

2. Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage

3. Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.

4. Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.

5. reduction of fn1 function enables rescue of cardiac fusion in hand2 (show HAND2 Proteins) mutants

6. Fibronectin regulates epithelial organization during myocardial migration in zebrafish.

Human Fibronectin 1 (FN1) interaction partners

1. TGFB1 (show TGFB1 Proteins)-mediated PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and p38 MAP kinase (show MAPK14 Proteins) dependent alternative splicing of fibronectin extra domain A in human podocyte culture has been reported.

2. The findings of this study provide evidence highlighting the prominent role played by FN1 in stimulating glioma growth, invasion, and survival through the activation of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.

3. The simultaneous delivery of multiple proinflammatory payloads to the cancer site conferred protective immunity against subsequent tumor challenges. A fully human homolog of IL2 (show IL2 Proteins)-F8-TNF (show TNF Proteins)(mut (show MUT Proteins)), which retained selectivity similar to its murine counterpart when tested on human material, may open new clinical applications for the immunotherapy of cancer.

4. Under the same condition, p53 (show TP53 Proteins) protein expression, but not mRNA expression, was reversed by MG132. Taken together, our data demonstrate that the level of FN expression is associated with the status and expression of p53 (show TP53 Proteins) in breast cancer cells

5. Our study thus demonstrates the dual roles of PTHrP on TGF-b1 signaling and FN up-regulation for the first time in glomerular mesangial cells . These data also provided new insights to guide development of therapy for diabetic kidney disease

6. data suggest that miR (show MLXIP Proteins)-200b regulates EMT (show ITK Proteins) of chemo-resistant breast cancer cells by targeting FN1. miR (show MLXIP Proteins)-200b-based therapy may be an effective strategy in treating advanced breast cancer patients.

7. Identification of novel integrin-binding domain mutations in FN1 in patients with glomerulopathy with fibronectin deposits.

8. Fibronectin fragments (FNFr) function as matrikines driving the chemotactic affinity of prostate cancer cells via the alpha5beta1 integrin.

9. B. burgdorferi does not primarily target insoluble matrix Fn deposited on endothelial surfaces but, instead, recruits and induces polymerization of soluble plasma Fn (pFn), an abundant protein in blood plasma that is normally soluble and nonadhesive.

10. miR1271 inhibited glioma cell growth by targeting FN1, and a low level of miR1271 in glioma tumor tissues was associated with lower survival rates in patients with glioma.

Mouse (Murine) Fibronectin 1 (FN1) interaction partners

1. Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.

2. Cdc42 (show CDC42 Proteins) bypasses the need for exogenous fibronectin by stimulating cellular fibronectin deposition under the newly formed lamellipodia.

3. Factor XIII (show UGDH Proteins)-A and TG2 (show TGM2 Proteins) regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.

4. we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 (show SPP1 Proteins) as the central mediators in these processes

5. PD increased CKIP-1 and Nrf2 (show NFE2L2 Proteins) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (show ICAM1 Proteins)

6. Histone methyltransferase Suv39h1 (show SUV39H1 Proteins) attenuates high glucose-induced fibronectin and p21(WAF1 (show CDKN1A Proteins)) in mesangial cells

7. fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities

8. The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK (show MAPK14 Proteins) pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.

9. analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation

10. scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown.

Cow (Bovine) Fibronectin 1 (FN1) interaction partners

1. plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.

2. Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (show TGFB1 Proteins) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.

3. Putative function of fibronectin and its receptor (integrin alpha(5 (show ITGA5 Proteins))beta(1)) in male and female gametes during bovine fertilization in vitro.

4. These results highlight a crucial role for caveolin-1 (show CAV1 Proteins) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.

5. P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn

Horse (Equine) Fibronectin 1 (FN1) interaction partners

1. The expression of extracellular matrix molecules fibronectin and osteopontin (show SPP1 Proteins) in vitreous and retina samples in autoimmune uveitis was investigated.

Pig (Porcine) Fibronectin 1 (FN1) interaction partners

1. The expression of the differentiation and stemness genes, FN1 and SOX9 (show SOX9 Proteins), is accompanied by cell proliferation.

2. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.

3. The relationship between hyaluronan synthesis and levels of versican (show Vcan Proteins), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.

4. fibronectin has a cryptic binding site for tenascin (show TNC Proteins)

Xenopus laevis Fibronectin 1 (FN1) interaction partners

1. Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase (show DSE Proteins)-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase (show DSE Proteins)-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.