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Human Fibronectin Protein expressed in Human Cells - ABIN2002555
Liu, Fedorov, Pollard, Lattman, Almo, Magnus: Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii. in Journal of structural biology 1998
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Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
reduction of fn1 function enables rescue of cardiac fusion in hand2 (show HAND2 Proteins) mutants
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
Data show the expression of ED-B fibronectin was much higher in mesenchymal than prostate cancer cells even after the epithelial to mesenchymal transition. Epithelial to mesenchymal transition is a key step for tumor progression contributing to the metastatic spread. Therefore, circulating cancer cells could seed into the metastatic niche taking advantage from the ED-B fibronectin that secrete their own.
Thrombomodulin (TM (show THBD Proteins)) promotes angiogenesis by enhancing cell adhesion, migration, and FAK (show PTK2 Proteins) activation through interaction with fibronectin.
thyroid nodule stiffness is correlated with fibrosis and expression of Gal-3 (show LGALS3 Proteins) and FN-1
EGF (show EGF Proteins) and TNFalpha (show TNF Proteins) cooperatively promoted the motility of HCC (show FAM126A Proteins) cells mainly through NF-kappaB (show NFKB1 Proteins)/p65 (show GORASP1 Proteins) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF (show EGF Proteins) and TNFalpha (show TNF Proteins) in promoting HCC (show FAM126A Proteins), and provide potential targets for HCC (show FAM126A Proteins) prevention and treatment.
RT-PCR together with Sanger sequencing verified the presence of the FN1-ALK fusion transcripts
Fibronectin is readily modified by ONOOH at low (physiologically-relevant) molar ratios of oxidant to protein.
The 45 kDa gelatin-binding domain of fibronectin is responsible for the binding to TGM2 (show TGM2 Proteins).
Proteomics study showed a strong association of FN1, A2M (show A2M Proteins), C4BPA (show C4BPA Proteins) and CFB (show CFB Proteins) in molecular subtypes of breast cancer. The findings also revealed the altered level expressions of these selected proteins could classify BC subtypes through plasma and tissue based expression analysis
FN1/CCL2 (show CCL2 Proteins) levels are elevated in the bronchoalveolar lavage fluid from pulmonary sarcoidosis patients.
Cancer-associated fibroblasts organize the fibronectin matrix and promote directional prostate cancer cell migration.
Factor XIII (show UGDH Proteins)-A and TG2 (show TGM2 Proteins) regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 (show SPP1 Proteins) as the central mediators in these processes
PD increased CKIP-1 and Nrf2 (show NFE2L2 Proteins) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (show ICAM1 Proteins)
Histone methyltransferase Suv39h1 (show SUV39H1 Proteins) attenuates high glucose-induced fibronectin and p21(WAF1 (show CDKN1A Proteins)) in mesangial cells
fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities
The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK (show MAPK14 Proteins) pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.
analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation
scleraxis was required for TGFbeta-induced fibronectin expression: TGFbeta lost its ability to induce fibronectin expression following scleraxis knockdown.
The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 (show LGALS3 Proteins) as opposed to fibronectin.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.
Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (show TGFB1 Proteins) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
Putative function of fibronectin and its receptor (integrin alpha(5 (show ITGA5 Proteins))beta(1)) in male and female gametes during bovine fertilization in vitro.
These results highlight a crucial role for caveolin-1 (show CAV1 Proteins) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.
P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn
The expression of extracellular matrix molecules fibronectin and osteopontin (show SPP1 Proteins) in vitreous and retina samples in autoimmune uveitis was investigated.
The expression of the differentiation and stemness genes, FN1 and SOX9 (show SOX9 Proteins), is accompanied by cell proliferation.
The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.
The relationship between hyaluronan synthesis and levels of versican (show Vcan Proteins), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
fibronectin has a cryptic binding site for tenascin (show TNC Proteins)
Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase (show DSE Proteins)-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase (show DSE Proteins)-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
, gene C
, cold-insoluble globulin
, migration-stimulating factor
, cumulus cell-specific fibronectin 1 transcript
, embryo-specific fibronectin 1 transcript
, fibronectin ED-A- region
, fibronectin variable region