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Human GSTP1 Protein expressed in Wheat germ - ABIN1306100
Andrukhova, Salama, Krssak, Wiedemann, El-Housseiny, Hacker, Gildehaus, Andrukhov, Mirzaei, Kocher, Zuckermann, Aharinejad: Single-dose GSTP1 prevents infarction-induced heart failure. in Journal of cardiac failure 2014
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Patients with CYP2C19 (show CYP2C19 Proteins)*2 were at increased risk and CYP2C19 (show CYP2C19 Proteins)*2, CYP3A5 (show CYP3A5 Proteins)*3 and GSTP1 have synergistic influence on CYC (show CYCS Proteins) failure.
Individuals with ASD (show ARSD Proteins) (autism spectrum disorder)showed a significant diminished level of reduced glutathione, however, the distribution of GSTT1 (show GSTT1 Proteins), GSTM1 (show GSTM1 Proteins), and GSTP1 polymorphisms was not found to be associated with autism in this study population.
CML (show BCR Proteins) patients with carriage of heterozygous and homozygous variant genotypes of GSTP1 Ile105Val and GSTT1 (show GSTT1 Proteins) null, have a higher risk for development of resistance to IM.
No significant differences in allelic or genotypic frequencies of GPX1 (show GPX1 Proteins) rs1050450 or GSTP1 rs1695 were detected between Chinese schizophrenia cases and controls.
the GSTP1 Ile105Val polymorphism is not associated with the development of gynecological cancer (meta-analysis).
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1, RAD51 (show RAD51 Proteins), XRCC1 (show XRCC1 Proteins) and XRCC3 (show XRCC3 Proteins) genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 (show XRCC3 Proteins) and RAD51 (show RAD51 Proteins) genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 (show XRCC3 Proteins) gene.
The SNPs in CYP1A1 (show CYP1A1 Proteins), GSTP1 and XRCC1 (show XRCC1 Proteins) genes did not show significant association with complete remission (CR) rate, overall survival (OS) or event free survival (EFS (show EFS Proteins)). However, XRCC1 (show XRCC1 Proteins) Arg194Trp SNP was associated with higher drug toxicity; carriers of variant genotypes (CT and TT) had a significantly higher frequency of myelosuppression compared to those with the wild CC genotype
There were significant differences in GSTP1 (rs1138272 and rs1695) genotype or allele frequencies between the infertile and fertile groups and synergy effects of GSTP1 and NAT2 (show SLC38A1 Proteins) polymorphisms might lead to significant increase of infertility risk.
Significantly higher frequency of the GSTP1 polymorphism was observed in Extremely Low Birth Weight Preterm Infants with Bronchopulmonary Dysplasia.
Polymorphisms of GSTP1 rs1695 and ABCC2 (show ABCC2 Proteins) rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy. Kaplan-Meier survival analysis indicated that survival with GSTP1 AG+ GG was significantly longer than in patients with AA gene (P<0.05), and survival with ABCC2 (show ABCC2 Proteins) CT + TT was significantly longer than in patients with CC gene.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS (show TLR4 Proteins)- or IKKbeta (show IKBKB Proteins)-induced production of GM-CSF (show CSF2 Proteins). These studies indicate a complex role for GSTP in modulating NF-kappaB (show NFKB1 Proteins), which may involve S-glutathionylation of IKK (show CHUK Proteins) proteins, and interaction with NF-kappaB (show NFKB1 Proteins) family members.
GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid.
our study reveals the novel role of GSTP1 in regulation of iNOS (show NOS2 Proteins) by affecting S-nitrosylation, dimerization, and stability.
These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected]
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation.
GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress.
Report increased GSTP1 in airways of asthmatic mice.
DNIC storage function of GST P1-1 and ability of MRP1 (show ABCC1 Proteins) to efflux DNICs are vital in protection against NO cytotoxicity
Gst-pi expression of the prostate cancers are dependent on metastatic site.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
, deafness, X-linked 7
, fatty acid ethyl ester synthase III
, glutathione S-transferase P
, GST 7-7
, Glutathione-S-transferase placental enzyme pi type
, Glutathione-S-transferase, placental enzyme pi type
, chain 7
, glutathione S-transferase pi 2
, glutathione S-transferase, pi 2
, glutathione-S-transferase, pi 1
, Glutathione S-transferase P
, GST-pi enzyme
, glutathione S-transferase P 1
, GST YF-YF
, Gst p-1
, gst P1
, preadipocyte growth factor