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Human GSTP1 Protein expressed in Wheat germ - ABIN1306100
Andrukhova, Salama, Krssak, Wiedemann, El-Housseiny, Hacker, Gildehaus, Andrukhov, Mirzaei, Kocher, Zuckermann, Aharinejad: Single-dose GSTP1 prevents infarction-induced heart failure. in Journal of cardiac failure 2014
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Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors.
The present study findings provide the insights that miR133b reduces cisplatin resistance and its overexpression contributes to the suppression of the malignant growth and aggressiveness of cisplatinresistant nonsmall cell lung cancer cells by targeting GSTP1.
Through translational prospective study, the GSTP1 Ile105Val polymorphism emerges as prognostic marker in de novo large B-cell lymphoma patients.
GSTP1 polymorphism is associated with Cervical Cancer in Human Papilloma Virus Infected patients.
The current analyses suggests significant association was found between GSTM1 (show GSTM1 Proteins) variants and the risk of childhood acute lymphoblastic leukemia (ALL), while no association were found between GSTT1 (show GSTT1 Proteins) and GSTP1 Ile105Val polymorphism and childhood ALL risk
GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.
the recessive model of GSTP1 g.313A>G is the best fit inheritance model to predict the susceptible gene effect (OR: 2.3, 95% CI: 1.11-4.92, P = 0.020). In conclusion, statistically significant associations of GSTP1 g.313A>G (A/G, G/G) and g.341C>T (C/T) genotypes with coronary artery disease were observed.
The GSTP1 AG genotype of Alzheimer's disease was significantly lower (p = 0.005; OR = 0.57, 95% CI: 0.38-0.84) in the patients (41.1%) than the control group (56.5%).
Study provides evidence that high expression of CLDN6 (show CLDN6 Proteins) confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53 (show TP53 Proteins).
Patients with CYP2C19 (show CYP2C19 Proteins)*2 were at increased risk and CYP2C19 (show CYP2C19 Proteins)*2, CYP3A5 (show CYP3A5 Proteins)*3 and GSTP1 have synergistic influence on CYC (show CYCS Proteins) failure.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS (show TLR4 Proteins)- or IKKbeta (show IKBKB Proteins)-induced production of GM-CSF (show CSF2 Proteins). These studies indicate a complex role for GSTP in modulating NF-kappaB (show NFKB1 Proteins), which may involve S-glutathionylation of IKK (show CHUK Proteins) proteins, and interaction with NF-kappaB (show NFKB1 Proteins) family members.
GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid.
our study reveals the novel role of GSTP1 in regulation of iNOS (show NOS2 Proteins) by affecting S-nitrosylation, dimerization, and stability.
These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected]
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation.
GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress.
Report increased GSTP1 in airways of asthmatic mice.
DNIC storage function of GST P1-1 and ability of MRP1 (show ABCC1 Proteins) to efflux DNICs are vital in protection against NO cytotoxicity
Gst-pi expression of the prostate cancers are dependent on metastatic site.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
, deafness, X-linked 7
, fatty acid ethyl ester synthase III
, glutathione S-transferase P
, GST 7-7
, Glutathione-S-transferase placental enzyme pi type
, Glutathione-S-transferase, placental enzyme pi type
, chain 7
, glutathione S-transferase pi 2
, glutathione S-transferase, pi 2
, glutathione-S-transferase, pi 1
, Glutathione S-transferase P
, GST-pi enzyme
, glutathione S-transferase P 1
, GST YF-YF
, Gst p-1
, gst P1
, preadipocyte growth factor