Browse our anti-MMP 9 (MMP9) Antibodies

Human Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. data showed that polymorphisms of MMP8 and MMP9 may be associated with breast cancer risk in the Chinese Han population.

2. Andecaliximab (GS-5745, a monoclonal antibody targeting MMP9)monotherapy achieved target engagement without dose-limiting toxicity. Andecaliximab + mFOLFOX6 showed encouraging clinical activity without additional toxicity in patients with HER2-negative gastric/GEJ adenocarcinoma

3. Semen litchi drug serum can inhibit proliferation of hepatoma cells in vitro. The anti-hepatoma effect of semen litchi drug serum may be exerted through down-regulating the expression of VEGF and MMP-9 and inhibiting angiogenesis of hepatocellular carcinoma.

4. The expression of MMP-1 and MMP-9 is up-regulated by smooth muscle cells after their cross-talk with macrophages in high glucose conditions.

5. The authors investigated whether MMP9 gene polymorphism were a risk for POP. The results showed there were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases of POP and controls in Brazilian women.

6. Salivary diagnostics cannot be used to assess systemic levels of MMP-9 and MPO in CAD patients, neither at rest nor after acute physical exercise.

7. S100A8/A9 induced the activation of NF-kappaB and expression of MMP-9 protein through facilitating secretion of TNFalpha from macrophages, which may play a role in triggering extracellular matrix degradation and cardiac rupture.

8. Fecal MMP-9 is a reliable biomarker in detecting endoscopic activity in both ulcerative colitis and Crohn's disease patients.

9. Glucose starvation promotes MMP-9 expression via LKB1-AMPK-signaling in cancer cell lines.

10. Results showed high expression levels of MMP2 or MMP9 in ovarian cancer tissues compared to the adjacent normal ones and positively correlated with TP73-AS1 expression level.

11. In giant cell arteritis, invasion of vasculitogenic T cells and monocytes, formation of neoangiogenic networks, and neointimal growth all require the enzymatic activity of MMP-9.

12. Bioinformatics analysis predicted that miR-34c and miR-613 targeted with 3'-UTR of DANCR, besides, miR-34c and miR-613 also targeted with 3'-UTR of MMP-9, which was validated by luciferase reporter assay

13. Matrix metalloproteinase-9 is overexpressed in the lungs of adolescents with primary spontaneous pneumothorax scheduled for surgical intervention.

14. Increased serum MMP-9 levels in the short-term phase of ischemic stroke were associated with 3-month cognitive impairment, independently of established risk factors.

15. This study identified significant interaction between two new genes, COL5A3 and MMP9, which may be accounted for by a degradation of COL5A3 by MMP9 influencing eczema susceptibility

16. We document that MMP-9 cleaves a number of known and novel achalasia-associated autoantigens into remnant epitopes and therefore might be a major player during the pathogenesis of achalasia.

17. Polymorphism rs17567 metalloproteinase 9 (MMP9) was associated with gestational diabetes (GDM) in the Euro-Brazilian population.

18. Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression.

19. The positive correlation between active MMP-9 and COPD Assessment Test (CAT) score in chronic obstructive pulmonary disease (COPD) patients and the inverse relationship between total MMP-9 concentration and the degree of airway obstruction reflect the complex role of MMP-9 in COPD.

20. Synergistic effect of l-ascorbic acid and hyaluronic acid on the expressions of matrix metalloproteinase-3 and -9 in human chondrocytes.

Mouse (Murine) Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. Targeted knockdown of MMP3 and MMP9 reduce primary tumor development and subsequent metastasis of aggressive adenocarcinoma cells. Nuclear MMP9 localized in central area of primary tumors and in lung-metastatic tumor nodules.

2. Our study demonstrated that hypoxia increases the expression of MMP-2 and MMP-9 through the 15-lipoxygenase/15-HETE pathway, and that MMP-2 and MMP-9 promote PAEC angiogenesis. These findings suggest that MMP-2 and MMP-9 may serve as new potential therapeutic targets for the treatment of pulmonary arterial hypertension (PAH).

3. These data suggest that FAK/PI3K/Akt signaling pathway and MMP-2 and MMP-9 may be involved in the development of Herpes Simplex Keratitis.

4. these results indicated that dendritic cells-derived MMP-9 is the crucial factor for dendritic cell migration

5. The present study reveals the positive correlation of CypA/CD147 signaling and osteoclast-related MMP-9 expression in mice inflammatory periapical lesions progression. Therefore, intervention of CypA/CD147 signaling could probably provide a potential therapeutic target for attenuating inflammatory bone resorption.

6. data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema.

7. Transfection with either a mimic or an inhibitor of miR-29b-1-5p confirmed that downregulation of PHLPP1 upregulates Akt-dependent NF-kappaB signalling leading to activation of matrix metalloproteinases 2 and 9, players in the degradation of extracellular matrix during Helicobacter pylori infection.

8. onsistent with a role for LCN2 in MMP-9 regulation, regenerating muscle also displayed a significant increase in fibrosis and lower ( P = 0.07) MMP-9 activity in LCN2(-/-) mice at 2 days postinjury. These data highlight a novel role for LCN2 in muscle regeneration and suggest that changes in adipokine expression can significantly impact skeletal muscle repair.

9. While the general principles concerning MMP-2 and MMP-9 function discussed here are relevant to all inflammatory situations, the details regarding substrates and molecular mechanisms of action are likely to be specific for neuroinflammation.

10. the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status.

11. results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading

12. MMP-9 but not MMP-2 levels remained increased in the brains and, to a higher extend, in the spleens of the WT mice even during the remission phase, which is in line with the role of MMP-9 as a useful marker and a protective factor for experimental autoimmune encephalomyelitis (EAE) in the remission phase.

13. Created was a MMP-2/-9 double knockout (DKO) mice. Epithelial wound healing was dramatically delayed in adult DKO mice and when the DKO was combined with the PyVmT oncogene, the biologically related process of mammary tumorigenesis was inhibited in a site-specific manner.

14. alpha2-antiplasmin increases brain MMP-9 levels during thromboembolic ischemic stroke in a dose-dependent fashion suggesting a mechanistic link. Results show that MMP-9 is essential for many of the harmful effects of alpha2-antiplasmin in promoting blood-brain barrier breakdown, swelling, hemorrhage and ischemic brain injury.

15. MMP-9 overexpression increased the number of mice that exhibited traumatic brain injury-induced spontaneous seizures, and MMP-9 knockout decreased the appearance of seizures.

16. omega-3 reduces MMP-9 gene expression and improves myoblast engraftment, satellite cell activation, and muscle regeneration by mechanisms involving, at least in part, the regulation of macrophages.

17. These results indicated that MMP-9/2 activation in spinal microglia plays a key role in incision-induced mechanical allodynia in mice.

18. PARP-1, via manipulating the binding of NF-kB/AP-1 at the MMP-9 promoter, regulates MMP-9 expression, which helps maintain mitochondrial homeostasis.

19. fracture union in matrix metalloproteinase 9 deficient mice

20. Study in inflammatory bowel disease (IBD) Mmp-9 knock-out mice model found no differences in clinical or histopathological parameters after genetic or pharmacological inhibition of MMP-9. Therefore suggesting that MMP-9 upregulation is a consequence of the inflammatory process and unlikely represents a therapeutic target in IBD.

Horse (Equine) Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. elevated in placentas of mares retaining fetal membranes

Pig (Porcine) Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. MMP9 and VEGF, but not MMP13 or FGF23 may have roles in bone lesions in the hypovitaminosis D kyphotic pig model

2. Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.

3. Increased MMP-9 expression is associated with carotid atherosclerotic plaque.

4. For A3011G, the GG genotype was associated with a significantly higher (p < 0.05) number of live births than those recorded for AA sows and the additive effect was significant

5. Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis

6. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.

7. Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.

8. FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF

9. Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.

10. contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro

11. The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-9)in the corpus luteum of swine during luteolysis are reported.

12. Our data define pericyte interactions as a main inducer of endothelial MMP secretion and propose a new role for pericyte-endothelial cell crosstalk at the BBB in vitro

13. Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

14. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.

15. The expression of MMP2 and MMP9 in lung injury induced by mechanical stress, hypoxic injury, and septic shock in anesthetized swine are reported.

Cow (Bovine) Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.

2. These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.

3. Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.

4. Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.

5. Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

6. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

7. expression of mRNA and protein during deciduous tooth resorption in odontoclasts

8. results suggest a significant role of matrix metalloproteinase-2 and-9 in growth and development of bovine follicle

9. Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha, hepatocyte growth factor, and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.

10. MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta

11. Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.

12. In cervix, MMP9 is only active during the final cervical ripening process at parturition.

13. Relative expression of MMP-9 and MMP-2 increased in synovial fluid from calves with experimentally induced septic arthritis, with relative expression remaining high for several days after E. coli infection.

14. The expression level of MMP-9 was stably maintained, but was relatively low compared to that of MMP-2 during bovine gestation.

Zebrafish Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. The data suggest that MMP9 and MMP13 might play a key role in the inflammatory phase of heart regeneration in zebrafish, by mediating leukocyte recruitment via the activation of chemokines, in particular, CXCL8.

2. Mmp9 is dispensable for Hematopoietic stem cells budding, and is required for proper colonization of secondary niches.

3. The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.

4. elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.

5. Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.

6. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13.

7. study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth

8. From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.

9. expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.

Xenopus laevis Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. The MMP-9 gene was duplicated and differentiated into two genes, one was specialized in a common ancestor of X. laevis and X. tropicalis expressed in degenerating and remodeling organs in response to thyroid hormone during metamorphosis.

2. MMP-9TH is responsible in the larval epithelial apoptosis through degrading ECM components in the basal lamina, whereas MMP-9 is involved in the removal of dying epithelial cells during amphibian intestinal remodeling

3. metamorphic tail and intestine RNA levels of TIMP-2, MT1-MMP and Gel-A, but not MT3-MMP or TIMP-3, are elevated during periods of cell death and proliferation

4. matrix metalloproteinases 7, 9, and 18 are required in vivo for macrophage migration during embryonic development

Rabbit Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. Modulation of MMP-2 and MMP-9 is critical for extracellular matrix balance of intra-articular ligaments.

2. these findings highlight an important role for miR-133b/MMP-9 axis in atherosclerosis.

3. The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.

4. Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.

5. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases

6. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

7. Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.

8. Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.

9. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.

10. Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.

11. In experimental syringomyelia, MMP-9 plays an important role in causing edema in the presyrinx state.

12. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.

13. MMP promoter activation occurs as a function of thoracic aorta wall tension in transgenic mice

14. TGF-beta mediated MMP-9 induction may be regulated by the NF-kappaB, Smad3, and JNK pathways, whereas the IL-1beta mediated induction may be regulated by the NF-kappaB and p38 pathways.

Guinea Pig Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9) interaction partners

1. There was significantly higher expression of TGF-beta1 and MMP-9 in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

2. The results showed that MMP-2, MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.