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anti-Human MMP 9 Antibodies:
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Human Polyclonal MMP 9 Primary Antibody for ELISA, WB - ABIN3043582
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. in Journal of cardiovascular pharmacology 2010
Show all 67 Pubmed References
Mouse (Murine) Polyclonal MMP 9 Primary Antibody for IHC (p), ELISA - ABIN3043884
Zhou, Wan, Chu, Song, Xing, Wu, Yin: Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-?B pathway in tumor-bearing nude mice. in Oncology letters 2012
Show all 66 Pubmed References
Human Polyclonal MMP 9 Primary Antibody for WB - ABIN3044382
Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet. in Biochemical and biophysical research communications 2012
Show all 65 Pubmed References
Mouse (Murine) Polyclonal MMP 9 Primary Antibody for IHC (p), WB - ABIN4886671
Li, Yu, Shen, Zhou, Wang, Zhang: Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro. in World journal of gastroenterology 2008
Show all 37 Pubmed References
Human Polyclonal MMP 9 Primary Antibody for ELISA, ICC - ABIN6263289
Li, Zhang, Sun, Sun, Shi, Liu, Liu: MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. in International journal of oncology 2016
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Polyclonal MMP 9 Primary Antibody for IHC (p), IP - ABIN541028
Mikami, Katsube, Oya, Ishida, Kosaka, Mizuno, Mukai, Okada: Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis. in Laboratory investigation; a journal of technical methods and pathology 2011
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Human Polyclonal MMP 9 Primary Antibody for IF (p), IHC (p) - ABIN873171
Deng, Zhong, Gu, Shen, Guo: MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia. in Brain research bulletin 2013
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Human Polyclonal MMP 9 Primary Antibody for IF, IHC - ABIN6711844
Pan, Xiong, Yao, Xin, Zhang, Chen: Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells. in The international journal of biochemistry & cell biology 2012
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Human Polyclonal MMP 9 Primary Antibody for IHC (p), WB - ABIN390154
Behrens, Mathiak, Mangold, Kirdorf, Wellmann, Fogt, Rothe, Florin, Wernert: Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers. in International journal of cancer. Journal international du cancer 2003
Show all 11 Pubmed References
Human Monoclonal MMP 9 Primary Antibody for ELISA, IHC - ABIN4335100
Goktolga, Cavkaytar, Altinbas, Tapisiz, Tapisiz, Erdem: Effect of the non-specific matrix metalloproteinase inhibitor Doxycycline on endometriotic implants in an experimental rat model. in Experimental and therapeutic medicine 2015
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Findings provide evidence for a direct transcriptional regulation of MMP-9 gene expression by Ets-1 transcription factor in breast carcinogenesis.
Serum matrix metalloproteinase-9 level as a biomarker for colorectal cancer
Rg3 suppressed the expression of EMT-related transcription factors, especially the Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In summary, our data suggested that Rg3 could inhibit migration and invasion of NPC cells. This effect of Rg3 might be mediated through regulating MMP-2 and MMP-9 expressions and suppressing EMT.
imbalance between MMP-9 and TIMP-1 could play an important role in metastatic spread via lymphatic pathways of head and neck squamous cell carcinoma cells
This study suggests that the high expression of MMP-9 and VEGF-C could act as markers for the tumor presence in breast cancer. In addition, this study recommends that expression of MMP-9 and VEGF-C was significantly associated with lymph node status and may provide valuable diagnosis of lymph node metastasis in breast cancer patients.
From c-Fos to MMP-9: In control of synaptic plasticity to produce healthy and diseased mind
These findings suggest that MMP-9 expression suppression by casticin may act through inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, which in turn results in the inhibitory effects of casticin on cell migration and invasion in breast cancer cells. Therefore, casticin may have potential for use in the treatment of breast cancer invasion and metastasis.
The current study suggests that the variation of TIMP2 gene and its interaction with MMP9 gene might be associated with male infertility.
MMP9 expression is up-regulated by LINC01605 in bladder cancer.
Low density lipoprotein (-) induced the release of MMP-9 and TIMP-1 in monocytes through CD14.
In our study we found that only MMP-9 differentiates the patients with and without GO [Graves' orbitopathy ], and may be used as a marker of the disease severity in patients with this manifestation of GD [Graves' disease ].
Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of Ischemic stroke in a southern Chinese Han population
Serum MMP9 and TLR4 could be potential biomarkers for identifying acute aortic dissection, while the combined diagnostic value was higher in safely ruling out AAD.
The expression MMP-9 and S100A6 in the tear film decreased in keratoconus patients after corneal collagen crosslinking.
MMP9 levels were significantly increased in patients with abdominal/thoracic aortic aneurysms. TAA patients tended to have higher levels of MMP9 than AAA subjects.
Study of the in-situ expression and significance of tumor-associated macrophages (TAMs) biomarkers (CD68, CD163, and MMP-9) in breast cancer with different estrogen receptor (ER) status revealed that MMP-9 protein was not individually associated with overall survival (OS). High expression of MMP-9 in the CD68+/CD163+ TAMs was associated with worse OS in ER+ tumors but not in ER- cancers.
EIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation.
discriminatory ability in the diagnosis of bladder carcinoma of MMP-2 and MMP-9 expression was confirmed by receiver operating characteristic curve analysis that revealed a sensitivity and specificity of 100%. MMP-2 and MMP-9 levels were not correlated with grade or stage of the tumor
MMP9 was not significantly different in patients with rheumatoid factor positive rheumatoid arthritis, rheumatoid factor negative rheumatoid arthritis, undifferentiated arthritis, and controls.
Our results suggest that MMP-9 might be involved in the pathogenesis of H. pylori. PUD could be associated with cag PAI-dependent MMP-9 upregulation.
these results indicated that dendritic cells-derived MMP-9 is the crucial factor for dendritic cell migration
The present study reveals the positive correlation of CypA/CD147 signaling and osteoclast-related MMP-9 expression in mice inflammatory periapical lesions progression. Therefore, intervention of CypA/CD147 signaling could probably provide a potential therapeutic target for attenuating inflammatory bone resorption.
data strongly suggest that PARP-1 inhibition blunts elastase-induced MMP-2 and MMP-9 expression, which may be partly responsible for prevention of emphysema.
Transfection with either a mimic or an inhibitor of miR-29b-1-5p confirmed that downregulation of PHLPP1 upregulates Akt-dependent NF-kappaB signalling leading to activation of matrix metalloproteinases 2 and 9, players in the degradation of extracellular matrix during Helicobacter pylori infection.
onsistent with a role for LCN2 in MMP-9 regulation, regenerating muscle also displayed a significant increase in fibrosis and lower ( P = 0.07) MMP-9 activity in LCN2(-/-) mice at 2 days postinjury. These data highlight a novel role for LCN2 in muscle regeneration and suggest that changes in adipokine expression can significantly impact skeletal muscle repair.
While the general principles concerning MMP-2 and MMP-9 function discussed here are relevant to all inflammatory situations, the details regarding substrates and molecular mechanisms of action are likely to be specific for neuroinflammation.
the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status.
results suggest that in response to stretch, MMP-2 responds rapidly by inhibiting conversion of a MMP-2 to the active form, while a slower up-regulation of MMP-9 may play a role in the long-term remodeling of extracellular matrix in response to continuous mechanical loading
MMP-9 but not MMP-2 levels remained increased in the brains and, to a higher extend, in the spleens of the WT mice even during the remission phase, which is in line with the role of MMP-9 as a useful marker and a protective factor for experimental autoimmune encephalomyelitis (EAE) in the remission phase.
Created was a MMP-2/-9 double knockout (DKO) mice. Epithelial wound healing was dramatically delayed in adult DKO mice and when the DKO was combined with the PyVmT oncogene, the biologically related process of mammary tumorigenesis was inhibited in a site-specific manner.
alpha2-antiplasmin increases brain MMP-9 levels during thromboembolic ischemic stroke in a dose-dependent fashion suggesting a mechanistic link. Results show that MMP-9 is essential for many of the harmful effects of alpha2-antiplasmin in promoting blood-brain barrier breakdown, swelling, hemorrhage and ischemic brain injury.
MMP-9 overexpression increased the number of mice that exhibited traumatic brain injury-induced spontaneous seizures, and MMP-9 knockout decreased the appearance of seizures.
omega-3 reduces MMP-9 gene expression and improves myoblast engraftment, satellite cell activation, and muscle regeneration by mechanisms involving, at least in part, the regulation of macrophages.
These results indicated that MMP-9/2 activation in spinal microglia plays a key role in incision-induced mechanical allodynia in mice.
PARP-1, via manipulating the binding of NF-kB/AP-1 at the MMP-9 promoter, regulates MMP-9 expression, which helps maintain mitochondrial homeostasis.
fracture union in matrix metalloproteinase 9 deficient mice
Study in inflammatory bowel disease (IBD) Mmp-9 knock-out mice model found no differences in clinical or histopathological parameters after genetic or pharmacological inhibition of MMP-9. Therefore suggesting that MMP-9 upregulation is a consequence of the inflammatory process and unlikely represents a therapeutic target in IBD.
our findings demonstrate that MMP9 is important for tooth development and DSP is a novel target of MMP9 during dentinogenesis.
The findings support the correlation between age-related hearing loss and cognitive decline in C57BL/6J mice, and indicated that MMP9 expression in the auditory cortex and hippocampus may be associated with the underlying mechanisms.
In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression
elevated in placentas of mares retaining fetal membranes
Results provide evidence for the utility of MMP9 and TIMP1 as markers of age- and lactocrine-sensitive porcine female reproductive tract development.
Increased MMP-9 expression is associated with carotid atherosclerotic plaque.
For A3011G, the GG genotype was associated with a significantly higher (p < 0.05) number of live births than those recorded for AA sows and the additive effect was significant
Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1, and NGAL (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2, caspase-3 and BDNF
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
contribution of MMPs to the inflammatory breakdown of the blood-CSF barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-9)in the corpus luteum of swine during luteolysis are reported.
Our data define pericyte interactions as a main inducer of endothelial MMP secretion and propose a new role for pericyte-endothelial cell crosstalk at the BBB in vitro
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A, pro-MMP-9, MMP-2, VEGFR-1, VEGFR-2, and TIMP-1, which may contribute to the development of venous stenosis.
The expression of MMP2 and MMP9 in lung injury induced by mechanical stress, hypoxic injury, and septic shock in anesthetized swine are reported.
In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.
These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.
We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.
expression of mRNA and protein during deciduous tooth resorption in odontoclasts
results suggest a significant role of matrix metalloproteinase-2 and-9 in growth and development of bovine follicle
Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha, hepatocyte growth factor, and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.
MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta
Results suggest that MMP-2, MMP-9, and TIMP-2 mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
In cervix, MMP9 is only active during the final cervical ripening process at parturition.
Relative expression of MMP-9 and MMP-2 increased in synovial fluid from calves with experimentally induced septic arthritis, with relative expression remaining high for several days after E. coli infection.
The expression level of MMP-9 was stably maintained, but was relatively low compared to that of MMP-2 during bovine gestation.
Mmp9 is dispensable for Hematopoietic stem cells budding, and is required for proper colonization of secondary niches.
The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.
elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.
Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13.
study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth
From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.
expression and activity of MMP-2 and MMP-9 in the embryonic zebrafish.
The MMP-9 gene was duplicated and differentiated into two genes, one was specialized in a common ancestor of X. laevis and X. tropicalis expressed in degenerating and remodeling organs in response to thyroid hormone during metamorphosis.
MMP-9TH is responsible in the larval epithelial apoptosis through degrading ECM components in the basal lamina, whereas MMP-9 is involved in the removal of dying epithelial cells during amphibian intestinal remodeling
metamorphic tail and intestine RNA levels of TIMP-2, MT1-MMP and Gel-A, but not MT3-MMP or TIMP-3, are elevated during periods of cell death and proliferation
matrix metalloproteinases 7, 9, and 18 are required in vivo for macrophage migration during embryonic development
The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.
Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.
Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.
Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.
Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.
In experimental syringomyelia, MMP-9 plays an important role in causing edema in the presyrinx state.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
MMP promoter activation occurs as a function of thoracic aorta wall tension in transgenic mice
TGF-beta mediated MMP-9 induction may be regulated by the NF-kappaB, Smad3, and JNK pathways, whereas the IL-1beta mediated induction may be regulated by the NF-kappaB and p38 pathways.
There was significantly higher expression of TGF-beta1 and MMP-9 in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
The results showed that MMP-2, MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
92 kDa gelatinase
, 92 kDa type IV collagenase
, macrophage gelatinase
, matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, matrix metalloproteinase-9
, type V collagenase
, 92kD gelatinase
, 92kD type IV collagenase
, 92kDa gelatinase
, 92kDa type IV collagenase
, Gel B
, collagenase type IVB
, gelatinase B
, matrix metalloproteinase 9
, 92-kDa type IV collagenase
, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
, matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
, type IV collagenase MMP-9
, Matrix metalloproteinase-9
, matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, 75 kDa gelatinase