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Human NLRP3 Protein expressed in Wheat germ - ABIN1312675
Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012
Show all 5 Pubmed References
eight single nucleotide polymorphisms, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with Psoriasis Vulgaris and 612 healthy controls in the Chinese Han population, were genotyped.
Studied association between nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain containing 3 (NLRP3) gene polymorphisms and susceptibility for large artery atherosclerosis (LAA), ischemic stroke (IS) and microembolic signals (MES) in the Chinese Han population.
Data indicate that by inhibiting adenine nucleotide translocase 1 (ANT1 (show SLC25A4 Proteins)) and mitochondrial dysfunction, tyrosine phosphatase SHP2 (show PTPN11 Proteins) orchestrates an intrinsic regulatory loop to limit excessive NLR (show CXCR5 Proteins) family, pyrin domain-containing 3 protein (NLRP3) inflammasome activation.
our results indicate that NLRP3 inflammasome is a promising target for blocking or retarding EMT (show ITK Proteins)-mediated fibrosis in pulmonary silicosis. On basis of this mechanism, pirfenidone might be a potential drug for the treatment of silicosis
This study demonstrated that Hcy activates adipose NLRP3 inflammasomes in an adipocyte lyso-PC-dependent manner and highlights the importance of the adipocyte NLRP3 inflammasome in insulin (show INS Proteins) resistance.
this study identifies a new role of ILF2 (show ILF2 Proteins) in the regulation of the NLRP3 inflammasome.
SeV V protein inhibited the assembly of NLRP3 inflammasomes, including NLRP3-dependent ASC (show PYCARD Proteins) oligomerization, NLRP3-ASC (show PYCARD Proteins) association, NLRP3 self-oligomerization, and intermolecular interactions between NLRP3 molecules.
this study shows that NLRP3 regulates inflammation-induced pro-labor mediators in human myometrial cells
The increased expression of NLRP3 and caspase-1 (show CASP1 Proteins) in fetal membrane and placental tissues may be associated with the development of premature rupture of membrane.
Oxidative stress activates NLRP3 through upregulating CTSB (show CTSB Proteins) activity.
Studied the anti-inflammatory effects of corylin on attenuation of lipopolysaccharide (LPS)-induced inflammation and inhibition of activation of nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in LPS-activated BV2 cells.
Data suggest that Abl2 on chromosome 1 and Nlrp3 on chromosome 11 are key to spermatozoa function; here, genetic polymorphisms in Abl2 and Nlrp3 appear to regulate susceptibility of mouse spermatozoa to cryopreservation. (Abl2 = v-abl Abelson murine leukemia viral oncogene 2; Nlrp3 = NLR family pyrin domain containing protein-3)
TLR2 and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1beta (show IL1B Proteins) in diabetic mice. IL-1beta (show IL1B Proteins) causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity.
TRIM31 (show TRIM31 Proteins), through its E3 ubiquitin ligase (show MUL1 Proteins) activity, mediated K48-linked ubiqutination and proteasomal degradation of NLRP3.
fenofibrate attenuates oxidative stress and neuroinflammation in diabetic retinas, which is at least partially through modulating Nrf2 (show NFE2L2 Proteins) expression and NLRP3 inflammasome activation
results therefore demonstrate that manipulation of the IL33 (show IL33 Proteins)-NLRP3 axis may be an effective therapy to suppress neuroinflammation and improve the efficacy of antimalarial drug treatment of cerebral malaria.
NLRP3 inflammasome is inhibited by NSAIDs in mouse and rat models of Alzheimer's disease
These findings indicate that the NALP3 inflammasome is involved in H2O2induced type I collagen synthesis, which is mediated by the NFkappaB signaling pathway. Additionally, the NALP3 inflammasome contributes to the development of bleomycininduced pulmonary fibrosis.
25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3