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Human NLRP3 Protein expressed in Wheat germ - ABIN1312675
Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012
Show all 5 Pubmed References
While the detection of NLRP3 gene mutations may be viewed as confirmatory, CAPS (show CAPS Proteins) is still predominantly a clinical diagnosis; therefore, recently published diagnostic criteria do not require the demonstration of a mutation.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (show MEFV Proteins) domain 1 and 3 (NLRP1 and NLRP3) inflammasomes and induced the release of IL-1beta (show IL1B Proteins) and pyroptosis via a caspase-1 (show CASP1 Proteins)-related mechanism in human periodontal ligament cells (HPDLCs).
A total of 163 patients and 201 health controls were enrolled in this study and polymorphisms of NLPR1, NLRP3, and P2X7R genes were detected by PCR..Our study demonstrated the potentially significant role of NLRP1 rs878329 (G>C) in developing susceptibility to the partial seizures in a Chinese Han population
Similar carrier rate of the NLRP3-Q703K allele among patients with manifestations of autoinflammatory disease and an ethnically matched control group suggest that this variant, does not determine the clinical phenotype.
Saturated faty acids activated the NLRP3 inflammasome and stimulated the secretion of IL-1beta (show IL1B Proteins) cytokine, while polyunsaturated fatty acids were mainly inhibitors.
The results lead to the hypothesis that NLRP3-inflammasome and associated IL-1beta (show IL1B Proteins) release have potential as CVR biomarkers, particularly in post-AMI (show CFD Proteins) patients with otherwise low risk scores.
findings suggest that beside the RLR (show DHX58 Proteins) pathway, RNase L (show RNASEL Proteins) cleavage products can also activate the NLRP3-inflammasome pathway, which requires DHX33 (show DHX33 Proteins) (DExD/H-box helicase) and the mitochondrial adaptor protein MAVS (show MAVS Proteins).
Collectively, our findings show that inhibition of the NLRP3 inflammasome decreases foam cell formation of THP-1 macrophages via suppression of ox-LDL uptake and enhancement of cholesterol efflux, which may be due to downregulation of CD36 (show CD36 Proteins) expression and upregulation of ABCA1 (show ABCA1 Proteins) and SR-BI (show SCARB1 Proteins) expression, respectively.
This review surveys the involvement of the NLRP3 inflammasome in various signalling pathways and highlight different aspects of their influence on diabetic nephropathy. [review]
Data suggest that aggregates of amyloid beta(1-40) induce excessive generation of reactive oxygen species, MAPK (show MAPK1 Proteins)/NFkappaB (show NFKB1 Proteins) signaling activation, and NLRP3 inflammasome activation in retinal pigment epithelial cells mimicking changes seen in age-related macular degeneration; this mechanism is dependent on NADPH oxidase (show NOX1 Proteins).
Reperfusion therapy with recombinant human relaxin-2 (show RLN1 Proteins) (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS (show NOS3 Proteins)-dependent mechanism.
Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS (show ROS1 Proteins)-TXNIP (show TXNIP Proteins)-NLRP3 axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D.
Excessive chenodeoxycholic acid may represent an endogenous danger signal to activate NLRP3 inflammasome and initiate liver inflammation during cholestasis.
Cigarette smoke extract decreased NLRP3 protein abundance via increased ubiquitin-mediated proteasomal processing.
The NLRP3 inflammasome can be activated in Neospora caninum-infected macrophages, and plays a protective role in the host response to control N. caninum.
Hyperin inhibited lipopolysaccharide-induced inflammatory response in acute kidney injury by inhibiting TLR4 (show TLR4 Proteins) and NLRP3 signaling pathways.
Andrographolide can inhibit ovalbumin (show OVA Proteins)-induced asthma with a possible mechanism of ROS (show ROS1 Proteins) elimination, thus negatively regulate NF-kappaB (show NFKB1 Proteins) and NLRP3 inflammasome activation.
mitochondrial dysfunction contributed to NLRP inflammasome activation and was triggered by Ang II (show AGT Proteins) via AT1R (show AGTRAP Proteins).
Data suggest that advanced glycation end products act on bone marrow-derived macrophages to impair Nlrp3 inflammasome-mediated innate immunity.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3