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Human NLRP3 Protein expressed in Wheat germ - ABIN1312675
Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012
Show all 5 Pubmed References
Data show that in HK-2 (show HK2 Proteins) cells and unilateral nephrectomy model, NLRP3 and NLRP3 inflammasome member ASC (show PYCARD Proteins) were significantly augmented after treatment with contrast media and provide evidence that NLRP3 inflammasome mediated contrast-induced-acute kidney injury through modulating the apoptotic pathway.
BCL6 overexpression in SHR reduced blood pressure, NLRP3 expression and inflammation in the renal cortex of SHR
we have shown that a mutation of the NLRP3 gene can cause hearing loss in the absence of the other clinical signs and symptoms of CAPS (show CAPS Proteins) that are associated with other mutations of NLRP3. we show that a missense mutation, p.Arg918Gln (c.2753G > A), of NLRP3 causes autosomal-dominant sensorineural hearing loss in two unrelated families
Results demonstrated that in patients with ulcerative colitis (UC), expression of the NLRP3 protein was markedly enhanced in the inflamed colonic mucosa; expression levels of NLRP3 and its colocalization with cleaved caspase-1 (show CASP1 Proteins) positively correlated with disease severity. Also, further data suggested that the NLRP3 inflammasome might play a protective role in the pathogenesis of UC.
P2X7 receptor (show P2RX7 Proteins) inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL1B (show IL1B Proteins) pathway.
Review/Meta-analysis: NLRP3 p.Q705K snp not associated with the susceptibility to rheumatoid arthritis.
Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
These results indicated that Zinc inhibited NLRP3 inflammasome activation in the high glucosetreated humanperitoneal mesothelial cells.
findings provide support for a dysfunction in the autophagosomal-lysosomal pathway triggered and regulated by the NLRP3 inflammasome and glia maturation factor in human Alzheimer's disease (AD) brain that results in aggregated Abeta (show APP Proteins) and tauopathies. The autophagosomal-lysosomal pathway for clearance of Abeta (show APP Proteins) and p-tau is impaired in AD.
the results suggest that placentas from pregnant women with preeclampsia show higher expression of NLRP3 inflammasome, which may be involved in the exaggerated inflammatory state in preeclampsia
Activation of Nlrp3 inflammasome may contribute to MPTP (show PTPN2 Proteins)-induced neuroinflammation in SNpc, whereas miR (show MLXIP Proteins)-30e inhibits this process by targeting Nlrp3.
This study indicated that the NLRP3 inflammasome is significantly implicated in the progression of systemic inflammation-induced depression
findings provide compelling evidence of a role for Nlrp3 in nigral degeneration and neuroinflammation resulting from systemic rotenone exposure and suggest that the suppression of NLRP3 activity may be a rational neuroprotective strategy for toxin-associated PD
indicate the role of P2X7R (show P2RX7 Proteins) (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3 (show HSPB3 Proteins)) inflammasome activation in the process of pancreatic fibrosis in chronic pancreatitis (CP) and suggest that blockade of P2X7R (show P2RX7 Proteins)-NLRP3 inflammasome signaling pathway may represent a therapeutic strategy for CP and its fibrotic process.
TLR4 (show TLR4 Proteins) and NLRP3 are suppressed by alpinectin, which attenuates inflammation in DSS (show PMP22 Proteins)-induced acute colitis
High expression of NLRP3 is associated with radiculopathy.
NLRP3 improves the integrity of alveolar epithelial cell monolayers by enhancing cellular adherence
The NLRP3-inf (show GIF Proteins) lammasome is activated by diesel exhaust particles in ex vivo tissue explants from elastase-induced emphysema animal model, and this activation is inhibited by N-acetylcysteine.
Results show that Nlrp3 inflammasome is activated by CIRP (show CIRBP Proteins) in mouse lung vascular endothelial cells accompanied with caspase-1 (show CASP1 Proteins) activation, IL-1beta (show IL1B Proteins) release and induction of proinflammatory cell death pyroptosis.
This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 (show PTPN22 Proteins) plays a key role in the regulation of those 2 pathways.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3