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mutations of both Regnase-1 and Roquin (show RC3H1 Proteins) in T cells leads to massive lymphocyte activation and increased TH1 (show HAND1 Proteins) cells. In contrast, mutation of either Regnase-1 or Roquin (show RC3H1 Proteins) affected T cell activation to a lesser extent than the double mutation, indicating that Regnase-1 and Roquin (show RC3H1 Proteins) function nonredundantly in T cells. Regnase-1 is capable of repressing Roquin (show RC3H1 Proteins) mRNA.
our findings not only demonstrate that MCPIP1 plays an important role in early cortical neurogenesis but also reveal an unexpected link between neocortical development, immune regulators, and epigenetic modification.
MCPIP1 is a potent negative regulator of psoriatic skin inflammation through IL-17A (show IL17A Proteins) and IL-17C (show IL17C Proteins)
IL-17A (show IL17A Proteins)-mediated induction of MCPIP1 is involved in the regulation of local altered gene expression in suprabasal epidermal layers in psoriasis
Overexpression of MCPIP1 induced apoptosis.
MCPIP1 is the target of mmu-miR (show MLXIP Proteins)-27-5p.
MCPIP1-MSCs also expressed increased levels of proteins involved in angiogenesis, autophagy, and induction of differentiation
This studies demonstrated that MCPIP1 is an important mediator of minocycline-induced protection from brain ischemia.
Data indicate that MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) knockdown enhanced interleukin-17 (IL-17 (show IL17A Proteins))-mediated signaling.
MCPIP expression in the ischemic myocardium protects against adverse cardiac remodeling and dysfunction following myocardial infarction
data extend knowledge on roles of MCPIP1 in our model and link the protein to regulation of expression and stability of MYCN (show MYCN Proteins) through decrease of signaling via Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway.
Loss of MCPIP1 expression is associated with Clear Cell Renal Cell Carcinoma (show MOK Proteins) metastasis.
this study uncovered a novel IL-8 (show IL8 Proteins)-dependent mechanism via which MCPIP-1 maintains epithelial homeostasis
These data revealed that influenza A virus-induced expression of miR (show MLXIP Proteins)-9 negatively regulated MCPIP1 expression and partially acts as a brake on host MCPIP1-mediated antiviral effect.
MCPIP1 recognizes regions of the 3'UTR of C/EBPbeta (show CEBPB Proteins) mRNA.
SAHA-mediated suppression of the IL-6 (show IL6 Proteins) expression is achieved through increased recruitment of CEBPalpha to the MCPIP1 promoter and by relieving the miR (show MLXIP Proteins)-9-mediated inhibition of MCPIP1 expression in OA chondrocytes.
propose that KSHV infection inhibits a negative regulator of miRNA biogenesis (MCPIP1) and up-regulates critical miRNA processing components to evade host mechanisms that inhibit expression of viral miRNAs
both human and cynomolgus monkey MCPIP1 restrict simian immunodeficiency virus replication. Unlike SAMHD1, MCPIP1-mediated HIV-1 restriction cannot be overcome by SIV Vpx.
ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.
zinc finger CCCH-type containing 12A
, MCP-1 treatment-induced protein
, MCP-induced protein 1
, ribonuclease ZC3H12A
, zinc finger CCCH domain-containing protein 12A
, Zinc finger CCCH domain-containing protein 12A
, MCP induced protein 1