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Barhl2 is an amacrine-cell subtype identity-biasing factor that turns on within Atoh7-positive descendants.
by acting upstream of Shh signaling pathway, Barhl2 plays a crucial role in patterning the progenitor domains and establishing the positional identities of progenitor cells in the diencephalon.
The expression of Barhl2 in the thalamus and pretectum is related to, and regulated by, the expression of Pax6. Pax6 is known to be required for normal diencephalic development. The findings suggest that some of its actions might be mediated by its maintenance of a repressive influence over Barhl2 expression in the thalamus and pretectum.
results elucidate BARHL2 as a critical postmitotic regulator of dI1 subtype diversification, as well as its intermediate position in the dI1 genetic hierarchy
in the developing diencephalon, Caspase3 acts downstream of Barhl2 in limiting neuroepithelial cell proliferation by inhibiting beta-catenin activation.
Data suggest that Barhl2 may function to specify the identity of glycinergic amacrine cells from competent progenitors during retinogenesis.
Math1 directly regulates the Mbh genes in CGCs. Furthermore, a dominant-negative form of the Mbh proteins disrupted proper
BARHL2 plays roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival.
barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog
Barhl2 is part of a pathway regulating early programmed cell death and plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells.
Action of Xbh1 on ganglion cell development accounts for only a part of their activities during retinogenesis.
Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity).
BarH-class homeodomain transcription factor
, bar-class homeodomain protein MBH1
, barH-like 2 homeobox protein
, homeobox protein B-H1
, barH-class homeodomain transcription factor
, BarH-like 2
, BarH-like homeobox 2
, homeobox protein BarH-like 2
, homeodomain transcription factor BARX2B
, Bar homeobox protein XBH1