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Silencing of CDCA5 suppresses proliferation of gastric cancer cells by inducing G1-phase arrest via downregulating CCNE1 (show CCNE1 Proteins).
Sororin participates in the regulation of centromeric cohesion during meiosis in collaboration with SGO2-PP2A (show PPP2R4 Proteins).
The results suggest that CDCA5 functions as a critical gene supporting oral squamous cell carcinoma progression and that targeting CDCA5 may be a useful therapeutic strategy for oral squamous cell carcinoma.
phosphorylation plays unexpected roles in regulating the subcellular localization of Sororin.
the C-terminus of Sororin functions as an anchor binding to SA2 (show STAG2 Proteins), which facilitates other conserved motifs on Sororin to interact with other proteins to regulate sister chromatid cohesion and separation.
We propose that the Prp19 (show PRPF19 Proteins) complex and the splicing machinery contribute to the establishment of cohesion by promoting Sororin accumulation during S phase, and are, therefore, essential to the maintenance of genome stability.
A transcriptome-wide analysis revealed that SNW1 (show SNW1 Proteins) or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC (show APC Proteins)/C subunit APC2.
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia.
Data show that the MEK (show MAP2K1 Proteins)-ERK (show EPHB2 Proteins) pathway regulates cell cycle-related neuronal apoptosis (CRNA) by elevating the levels of cyclin D1 (show CCND1 Proteins), and the increase in cyclin D1 (show CCND1 Proteins) attenuates the activation of cyclin-dependent kinase 5 (cdk5 (show CDK5 Proteins)) by its neuronal activator p35 (show ANXA1 Proteins).
Sororin is phosphorylated by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 into proximity with SA2, resulting in the phosphorylation of SA2 and the removal of cohesin complexes from chromosomal arms.
Results indicate that Sororin regulation during meiosis is distinct from its regulation in mitotic cells and may suggest that it interacts with a distinctly different partner to ensure proper chromosome dynamics in meiosis.
Our results define Sororin as a determinant during mouse oocyte meiotic maturation by favoring DNA damage repair and chromosome separation, and thereby, maintaining the genome stability and generating haploid gametes.
The authors show that sororin is essential for embryonic development, cohesion maintenance, and proper chromosome segregation.
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of wapal which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair (Probable).
cell division cycle-associated protein 5
, sororin p35
, cell division cycle associated 5
, cell division cycle-associated protein 5-A