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anti-Human FOXP3 Antibodies:
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Human Polyclonal FOXP3 Primary Antibody for ChIP, ICC - ABIN153182
Andersson, Boasso, Nilsson, Zhang, Shire, Lindback, Shearer, Chougnet: The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 15 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for WB - ABIN3043158
Li, Ren, Wang, Gu, Hu, Ren, Hong, Wu, Liu, Li: T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease. in International immunopharmacology 2014
Show all 10 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for IHC (p) - ABIN3042405
Fu, Li, Yang, Gai, Jia, Lei, Li: FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape. in Acta histochemica 2013
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Human Polyclonal FOXP3 Primary Antibody for ICC, FACS - ABIN188539
Grant, Jung, Johnson, Kostakoglu, Hsi, Byrd, Jones, Leonard, Martin, Cheson: A phase 2 trial of extended induction epratuzumab and rituximab for previously untreated follicular lymphoma: CALGB 50701. in Cancer 2013
Show all 9 Pubmed References
Mouse (Murine) Monoclonal FOXP3 Primary Antibody for ICC, IHC - ABIN1169339
Lan, Wang, Raimondi, Wu, Colvin, de Creus, Thomson: "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 7 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for ICC, IF - ABIN153185
Ostroukhova, Qi, Oriss, Dixon-McCarthy, Ray, Ray: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. in The Journal of clinical investigation 2006
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Human Polyclonal FOXP3 Primary Antibody for FACS, IHC (p) - ABIN389295
Eisenberger, Seifried, Patey, Kappeler, Noel, Frey, Körner: FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions. in Transplantation 2009
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Baboon Monoclonal FOXP3 Primary Antibody for ICS, IHC - ABIN2689510
Brunkow, Jeffery, Hjerrild, Paeper, Clark, Yasayko, Wilkinson, Galas, Ziegler, Ramsdell: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. in Nature genetics 2001
Show all 3 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for IP, WB - ABIN549484
Cao, Zhao, Lei, Shen, Liu, Li, Liu, Shen, Zhang, Feng, Huang: Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Polyclonal FOXP3 Primary Antibody for FACS, IP - ABIN540415
Lim, Hillsamer, Banham, Kim: Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
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analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha.
RUNX3, a CD8(+) lineage-specific transcription factor, binds at the FOXP3-promoter to induce its transcription.
Multivariate analysis of OS only found CD8(+)/Foxp3(+) ratio to be independent prognostic factor (P = 0.022) om spinal chordoma.
Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. Increased expressions of USP21 and PIM2 in Treg cells from asthmatic patients were found.
Authors have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4(+) T cells of CRC patients.
Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p < 0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus.
In conclusion we suggest that genetic variants in FOXP3 gene may contribute to the pathogenesis of preeclampsia.
Data show that the forkhead Box Protein P3 (FOXP3) response element at the -310 bp region, but not the -2182 bp region, is mainly required for ubiquitin conjugating enzyme 9 (UBC9) activation by FOXP3.
The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability.
The concurrent overexpression of FoxM1 and FoxP3 was evident in gastric cancer and inversely correlated with patient survival.
Results suggest that -924A/G and +459T/C polymorphisms of the FOXP3 gene might be associated with unexplained recurrent spontaneous abortions (URSA) and -20G/A polymorphism is likely to be rare in Indian population and might not be associated with URSA.
mutations can cause early-onset insulin-requiring diabetes with or without other features of IPEX syndrome
The rs3761549, rs5902434, and rs2232365 are associated with an increased risk of acute graft-versus-host disease and decreased risk of post allogenic hematopoietic stem cell transplantation.
Genetic variations at SNP rs3761548 in the FOXP3 gene represent a risk factor for peptic ulcer.
Aberrant expression and methylation patterns of FoxP3 were detected in human T cells.
blood mononuclear cells in stable CAD patients express a ratio of FOXP3 isoforms that is characteristic for activated CD4+ T cells
this study suggested that macrophages in keloid tissues presented high activation status and were polarized toward the M2 subtype; moreover, these macrophages could promote Treg differentiation by upregulating Foxp3 expression.
FOXP3 polymorphisms may be important markers to determine susceptibility to IIP or CTP-ILD in Chinese population.
IPEX syndrome is associated with mutations in the forkhead box P3 (FOXP3) gene which causes impaired immune suppressive function.
NOTCH1 is a central mediator of TGFbetamediated FOXP3 expression and NOTCH1 inhibition produces a significant reduction of melanoma cell proliferation and viability.
Epigenetic modification is also thought to take essential part into the upregulation of Foxp3 from naive CD4 + Tcells.
Foxp3 vaccine promotes an immune response against tumor.
Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.
Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)
Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease
Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.
KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.
Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 alleviate intestinal inflammation in vivo.
the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2/Smad3/Smad4 signalling, ultimately resulting in abortion.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor)
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
Dendritic cells have the capacity to express Foxp3, which can be upregulated by exposure to Staphylococcal enterotoxin B.
the Treg transcription factor Foxp3 reprograms T cell metabolism by suppressing Myc and glycolysis, enhancing oxidative phosphorylation, and increasing nicotinamide adenine dinucleotide oxidation.
Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 and FoxP3 can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells.
An Essential Role for Scurfin in CD4+CD25+ T Regulatory Cells.
Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.
Foxp3 expression in lung epithelial cells, and not in Treg cells, inhibited OVA- and cockroach extract-induced asthma.
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.
regulatory role in intramuscular fat deposition
The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3