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anti-Human FOXP3 Antibodies:
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Human Polyclonal FOXP3 Primary Antibody for ChIP, ICC - ABIN153182
Andersson, Boasso, Nilsson, Zhang, Shire, Lindback, Shearer, Chougnet: The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 15 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for ICC, FACS - ABIN188539
Grant, Jung, Johnson, Kostakoglu, Hsi, Byrd, Jones, Leonard, Martin, Cheson: A phase 2 trial of extended induction epratuzumab and rituximab for previously untreated follicular lymphoma: CALGB 50701. in Cancer 2013
Show all 13 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for IHC (p) - ABIN3042405
Li, Ren, Wang, Gu, Hu, Ren, Hong, Wu, Liu, Li: T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease. in International immunopharmacology 2014
Show all 10 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for WB - ABIN3043158
Fu, Li, Yang, Gai, Jia, Lei, Li: FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape. in Acta histochemica 2013
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Mouse (Murine) Monoclonal FOXP3 Primary Antibody for ICC, IHC - ABIN1169339
Lan, Wang, Raimondi, Wu, Colvin, de Creus, Thomson: "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 7 Pubmed References
Human Polyclonal FOXP3 Primary Antibody for ICC, IF - ABIN153185
Ostroukhova, Qi, Oriss, Dixon-McCarthy, Ray, Ray: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. in The Journal of clinical investigation 2006
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Human Polyclonal FOXP3 Primary Antibody for FACS, IHC (p) - ABIN389295
Eisenberger, Seifried, Patey, Kappeler, Noel, Frey, Körner: FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions. in Transplantation 2009
Show all 6 Pubmed References
Polyclonal FOXP3 Primary Antibody for IHC (fro), WB - ABIN540719
Ochando, Yopp, Yang, Garin, Li, Boros, Llodra, Ding, Lira, Krieger, Bromberg: Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 3 Pubmed References
Polyclonal FOXP3 Primary Antibody for WB - ABIN540720
Lim, Hillsamer, Banham, Kim: Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Polyclonal FOXP3 Primary Antibody for FACS, IP - ABIN540415
Polanczyk, Carson, Subramanian, Afentoulis, Vandenbark, Ziegler, Offner: Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. in Journal of immunology (Baltimore, Md. : 1950) 2004
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analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
As IPEX awareness and characterization have increased, so has identification of FOXP3 mutations, with at least 70 to date. Review.
The lowered serum levels of IL-33 and Foxp3 in in recurrent pregnancy loss patients suggested that they might have an important role in the pathogenesis of the disease. Foxp3 rs2232365 SNP could be considered as a risk factor for recurrent pregnancy loss in Egyptian women.
CCAAT/enhancer-binding protein (C/EBP) functions as a safeguard that enhances Treg cell generation by dampening the inhibitory effect of IFN-gamma and IL-4 on Foxp3 expression.
These findings reveal unpredicted effects of FOXP3 in the biology of hematopoietic stem cells.
the interaction of ODNPs25 in HD or phosphorylation of Thr592 by TCR stimulation interferes with nuclease activity of SAMHD1, thereby stabilizing 3' untranslated region of Foxp3 and Helios mRNAs in long-term culture.
Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells.
The Foxp3 promoter was significantly hypermethylated in Latent autoimmune diabetes of adults (LADA) than controls.
The percentage of T-reg was inversely correlated with all miRNAs levels except for miR-31 and miR-181c (r-value = -0.68 to -0.78 and p-value = 0.015 to 0.003). FOXP3 expression exhibited a same degree of negative correlation with miR-31 and miR-155 expression levels (r = -0.57 and p = 0.05, for both). Increasing starvation duration led to a rise inTGF-beta1 protein levels (p<0.01), especially its active form (P<0.001).
Results found Foxp3 is both necessary and sufficient to program Treg-increased respiratory capacity and ability to utilize fatty acids (FA) to fuel oxidative phosphorylation. Foxp3 drives upregulation of components of all the electron transport complexes, increasing their activity and ATP generation by oxidative phosphorylation. FA beta-oxidation also results in selective protection of Foxp3(+) from FA-induced cell death.
MRNA expression of Foxp3 was significantly decreased, and expression of miR210 was significantly increased.
Reduced FOXP3 expression and Treg function in abdominal aortic aneurysm patients are regulated by SIRT1-induced FOXP3 deacetylation.
The Foxp3 rs2232365 A allele was associated with severe Pre-Eclampsia (PE) specifically [OR = 1.70; 95% CI: 1.12-2.58; p = 0.01], compared with mild PE. There were no haplotype associations with PE.
Destabilized FOXP3-EZH2 protein interaction via diverse mechanisms and consequent Treg abnormality may drive gastrointestinal inflammation.
nuclear FOXP3 expression correlated with low Ki-67 index and better outcome in breast invasive ductal carcinoma
The proportion of programmed cell death 1 ligand 1 (PD-L1)-positive cases was significantly higher in stage I-III versus metastatic patients and the presence of forkhead box P3 protein (FOXP3)-tumour-infiltrating lymphocytes (TILs) was associated with improved prognosis among non-metastatic patients.
The findings suggested an association between rejection episodes, posttransplant graft function, and the FOXP3 rs 3761648 polymorphism in in kidney transplant patients. Determination of FOXP3 rs 3761648 C/A genotype might be helpful for the identification of recipients with a lower risk of rejection and better graft survival.
Alternation of circadian clock modulates forkhead box protein-3 gene transcription in CD4+ T cells in the intestine.
Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma.
FOXP3(+) CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early-life gut colonization.
The association between FOXP3 rs2232365 polymorphism and knee osteoarthritis tended to yield negative results but the FOXP3 rs3761548 C allele was associated with elevated risk of OA in Grade 4 knee OA patients in a Turkish population.
These results suggest that murine extrathymic Foxp3+ DP T cells may represent a unique regulatory T cell subset.
Function of Central and Effector Foxp3(+) Regulatory T Cells.(
Study found that a large number of Foxp3-bound genomic sites in Treg cells were occupied by Foxp1 in both Treg cells and conventional T cells. In Treg cells, Foxp1 markedly increased Foxp3 binding to these sites. These results suggest that Foxp1 serves an essential non-redundant function in Treg cells by enforcing Foxp3-mediated regulation of gene expression and enabling efficient IL-2 signaling in these cells.
study dissects time-dependent mechanisms behind Foxp3-driven T-cell regulation and establishes the Foxp3-Tocky system as a tool to investigate the mechanisms behind T-cell immunotherapies.
Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and Treg-specific demethylated region demethylation.
Overall, these findings contribute to our understanding of the molecular mechanisms underlying the process of Foxp3 induction and may provide a rational basis for generating phenotypically and functionally stable iTreg cells.
Here we focus on the cytokines implicated in thymic development of Treg(T lymphocytes (Treg) expressing the transcription factor Foxp3), with a particular emphasis on the roles of interleukin-2 and IL-15
It has been shown that T-cell receptors-activated post-translational modification by O-linked N-Acetylglucosamine stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways.
This study demonstrated that adoptive transfer of CD4(+)CD25(+) Tregs can decrease mouse enteritis. Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.
FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing
the strength of TCR stimulation is a key factor for induction of the demethylation of Foxp3 conserved non-coding sequence 2 and the generation of stable Tregs
Stable Foxp3 expression in extrathymically induced regulatory T cells (iTreg) requires Forkhead box protein P1 (Foxp1). Foxp1 binds a promoter region and genetic elements, including three CNSs (CNS1-3) downstream of the transcriptional start site of Foxp3 to preserve permissive histone modifications.
Epigenetic modification is also thought to take essential part into the upregulation of Foxp3 from naive CD4 + Tcells.
Foxp3 vaccine promotes an immune response against tumor.
Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.
Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.
regulatory role in intramuscular fat deposition
The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3