Browse our anti-FOXP3 (FOXP3) Antibodies

Zebrafish Forkhead Box P3 (FOXP3) interaction partners

1. analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish

2. correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses

Atlantic Salmon (Salmo salar) Forkhead Box P3 (FOXP3) interaction partners

1. cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals

Human Forkhead Box P3 (FOXP3) interaction partners

1. nuclear FOXP3 expression correlated with low Ki-67 index and better outcome in breast invasive ductal carcinoma

2. The proportion of programmed cell death 1 ligand 1 (PD-L1)-positive cases was significantly higher in stage I-III versus metastatic patients and the presence of forkhead box P3 protein (FOXP3)-tumour-infiltrating lymphocytes (TILs) was associated with improved prognosis among non-metastatic patients.

3. The findings suggested an association between rejection episodes, posttransplant graft function, and the FOXP3 rs 3761648 polymorphism in in kidney transplant patients. Determination of FOXP3 rs 3761648 C/A genotype might be helpful for the identification of recipients with a lower risk of rejection and better graft survival.

4. Alternation of circadian clock modulates forkhead box protein-3 gene transcription in CD4+ T cells in the intestine.

5. Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma.

6. FOXP3(+) CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early-life gut colonization.

7. The association between FOXP3 rs2232365 polymorphism and knee osteoarthritis tended to yield negative results but the FOXP3 rs3761548 C allele was associated with elevated risk of OA in Grade 4 knee OA patients in a Turkish population.

8. Human Treg cells that ectopically expressed RNF31 displayed stronger immune-suppressive capacity, suggesting that RNF31 positively regulates both FOXP3 stability and Treg cell function.

9. rs3761548 polymorphism of FoxP3 gene is a risk factor for breast neoplasms

10. The increased expression of FOXP3, CTLA-4 and GITR represent higher activity of Treg cells.

11. Both CCL1 and CCL22 were expressed in most breast cancer tissues. CCL1 was significantly over-expressed in invasive breast cancer as compared to normal breast tissue. CCL1, but surprisingly not CCL22, showed a significant correlation with the number of tumor-infiltrating FoxP3+ Treg

12. Breast cancer CD4, FOXP3, and CXCL13 contents were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR), and their influence on distant disease-free survival (DDFS) was examined using univariable and multivariable Cox regression and Kaplan-Meier estimates in the entire cohort and in selected molecular subgroups.

13. review article: propose a model whereby modulations in metabolic programming lead to changes in DNA methylation at the Foxp3 locus to allow Foxp3 expression following the reversal of anergy.

14. Study suggests that asthma is significantly associated with higher differentially methylated regions within the promoter region of Foxp3 and positively linked with average exposure to CO,NO2, and PM2.5 during the 90 days prior to the blood draw.

15. There was a significant positive correlation between the expression of EBI3 and Foxp3 mRNA in the sarcoidosis group (r=0.786, P<0.001). Conclusion: IL-35 may be involved in the inflammatory process of sarcoidosis and play an important role in the pathogenesis of the disease.

16. TGF-b, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer

17. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing

18. Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha.

19. RUNX3, a CD8(+) lineage-specific transcription factor, binds at the FOXP3-promoter to induce its transcription.

20. Multivariate analysis of OS only found CD8(+)/Foxp3(+) ratio to be independent prognostic factor (P = 0.022) om spinal chordoma.

Mouse (Murine) Forkhead Box P3 (FOXP3) interaction partners

1. Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and Treg-specific demethylated region demethylation.

2. Overall, these findings contribute to our understanding of the molecular mechanisms underlying the process of Foxp3 induction and may provide a rational basis for generating phenotypically and functionally stable iTreg cells.

3. Here we focus on the cytokines implicated in thymic development of Treg(T lymphocytes (Treg) expressing the transcription factor Foxp3), with a particular emphasis on the roles of interleukin-2 and IL-15

4. It has been shown that T-cell receptors-activated post-translational modification by O-linked N-Acetylglucosamine stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways.

5. This study demonstrated that adoptive transfer of CD4(+)CD25(+) Tregs can decrease mouse enteritis. Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.

6. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing

7. the strength of TCR stimulation is a key factor for induction of the demethylation of Foxp3 conserved non-coding sequence 2 and the generation of stable Tregs

8. Stable Foxp3 expression in extrathymically induced regulatory T cells (iTreg) requires Forkhead box protein P1 (Foxp1). Foxp1 binds a promoter region and genetic elements, including three CNSs (CNS1-3) downstream of the transcriptional start site of Foxp3 to preserve permissive histone modifications.

9. Epigenetic modification is also thought to take essential part into the upregulation of Foxp3 from naive CD4 + Tcells.

10. Foxp3 vaccine promotes an immune response against tumor.

11. Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model

12. This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.

13. Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)

14. Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease

15. Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.

16. KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.

17. Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 alleviate intestinal inflammation in vivo.

18. the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2/Smad3/Smad4 signalling, ultimately resulting in abortion.

19. Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor)

20. Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.

Pig (Porcine) Forkhead Box P3 (FOXP3) interaction partners

1. sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids

2. In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection

Cow (Bovine) Forkhead Box P3 (FOXP3) interaction partners

1. GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.

2. Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.

3. regulatory role in intramuscular fat deposition

4. The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.

5. There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.

6. identification of Foxp3 expression in Treg cells

7. These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population

Horse (Equine) Forkhead Box P3 (FOXP3) interaction partners

1. The correlation of TH17-related TLR4 expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.

2. Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.

3. results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response