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We revealed that miR (show MLXIP Proteins)-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis
ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins)/MMP-9 (show MMP9 Proteins) signaling pathway.
Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer.
miR (show MLXIP Proteins)-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR (show MLXIP Proteins)-1307 might serve as a therapeutic target for ovarian cancer.
miR (show MLXIP Proteins)-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression.
Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis.
Loss of ING5 expression is associated with lung cancer.
Identified ING5 as a novel CDK2 (show CDK2 Proteins) substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E (show CCNE1 Proteins)/CDK2 (show CDK2 Proteins) and cyclin A (show CCNA2 Proteins)/CDK2 (show CDK2 Proteins). This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 (show CDK2 Proteins) substrate.
Results showed that ING5 gene expression is inhibited by miR (show MLXIP Proteins)-193a-3p and is instrumental in miR (show MLXIP Proteins)-193a-3p's role in activating BCa (show BLNK Proteins) chemoresistance.
Data indicate that ING5 associates with Tip60 (KAT5 (show KAT5 Proteins)) to form a complex with p53 (show TP53 Proteins).
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
inhibitor of growth family, member 5
, inhibitor of growth protein 5