Browse our anti-MBD2 (MBD2) Antibodies

Full name:: anti-Methyl-CpG Binding Domain Protein 2 Antibodies (MBD2)

On www.antibodies-online.com are 130 Methyl-CpG Binding Domain Protein 2 (MBD2) Antibodies from 22 different suppliers available. Additionally we are shipping MBD2 Proteins (3) and MBD2 Kits (1) and many more products for this protein. A total of 143 MBD2 products are currently listed.

Synonyms:: DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862

list all antibodies	Gene Name	GeneID	UniProt
	MBD2	8932	Q9UBB5
	MBD2	17191	Q9Z2E1
	MBD2	680172
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Most Popular Reactivities for anti-MBD2 (MBD2) Antibodies

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anti-Human MBD2 Antibodies:

anti-Mouse (Murine) MBD2 Antibodies:

anti-Rat (Rattus) MBD2 Antibodies:

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Relevant Pathways for anti-MBD2 Antibodies

Chromatin Binding

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Top referenced anti-MBD2 Antibodies

Human Polyclonal MBD2 Primary Antibody for IF, WB - ABIN1881531 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010 (PubMed)
Show all 3 Pubmed References
Human Polyclonal MBD2 Primary Antibody for IHC (p), IHC - ABIN188691 : Tan, Nakielny: Control of the DNA methylation system component MBD2 by protein arginine methylation. in Molecular and cellular biology 2006 (PubMed)
Show all 2 Pubmed References
Human Polyclonal MBD2 Primary Antibody for GS, WB - ABIN151224 : Ballestar, Paz, Valle, Wei, Fraga, Espada, Cigudosa, Huang, Esteller: Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. in The EMBO journal 2003 (PubMed)
Show all 2 Pubmed References
Human Polyclonal MBD2 Primary Antibody for ICC, IF - ABIN257102 : Kim, Kwak, Weitz: Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. in Molecular cell 2014 (PubMed)
Human Polyclonal MBD2 Primary Antibody for IHC, ELISA - ABIN334432 : Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. in Nucleic acids research 2005 (PubMed)
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Human Polyclonal MBD2 Primary Antibody for IHC, WB - ABIN2779675 : Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. in British journal of cancer 2008 (PubMed)
Show all 2 Pubmed References

More Antibodies against MBD2 Interaction Partners

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

CpG and methylation-dependent DNA binding and dynamics of the MBD2 (show DPEP2 Antibodies) protein at the single-molecule level have been reported.
Results show that MBD2 (show DPEP2 Antibodies) mediates epigenetic silencing of Htra1 (show HTRA1 Antibodies).
MBD2 (show DPEP2 Antibodies) has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
MBD2 (show DPEP2 Antibodies) expression was elevated in HCC (show FAM126A Antibodies) tissue, which suggesting MBD2 (show DPEP2 Antibodies) as a candidate prognostic marker of HCC (show FAM126A Antibodies).
downregulation of miR (show MLXIP Antibodies)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (show DPEP2 Antibodies) in the human OSCC cell line UM1.
Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Antibodies) domain and MBD2 (show DPEP2 Antibodies) C-terminus.
MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
The dynamics of MBD2 (show DPEP2 Antibodies) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.
Data suggest that MBD2 (show DPEP2 Antibodies) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (show DPEP2 Antibodies) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (show DPEP2 Antibodies) for methylated DNA.

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

It has been shown that chromatin localization of Mbd2 and Mbd3 (show MBD3 Antibodies) is highly overlapping, and both proteins are interdependent for chromatin association.
MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
Loss of Mbd2 resulted in impaired implementation of above DNA methylation (show HELLS Antibodies) changes associated with altered energy homeostasis, which then protected mice from HFD-induced obesity and insulin (show INS Antibodies) resistance.
Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.
MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (show HLX Antibodies).
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.
miR (show MLXIP Antibodies)-290/371-Mbd2-Myc (show MYC Antibodies) circuit regulates glycolytic metabolism to promote pluripotency.
these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (show SCN3A Antibodies) expression during postnatal development and seizure condition.
Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (show AMD1 Antibodies)).

MBD2 Antigen Profile

Antigen Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MBD2

methyl-CpG binding domain protein 2 (MBD2) antibody
methyl-CpG binding domain protein 2 (Mbd2) antibody
methyl-CpG binding domain protein 2 (mbd2) antibody
methyl-CpG binding domain protein 2 S homeolog (mbd2.S) antibody

DMTase antibody
MBD2 antibody
MBD2a antibody
NY-CO-41 antibody
wu:fa97f06 antibody
zgc:111862 antibody

Protein level used designations for MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID	SPECIES
455427	Pan troglodytes
100345590	Oryctolagus cuniculus
693801	Macaca mulatta
8932	Homo sapiens
17191	Mus musculus
337105	Danio rerio
399118	Xenopus laevis
497269	Gallus gallus
483975	Canis lupus familiaris
100337206	Bos taurus
680172	Rattus norvegicus

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Show all anti-Methyl-CpG Binding Domain Protein 2 (MBD2) Antibodies with Pubmed References

Human Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) interaction partners

Antigen Summary

Alternative names and synonyms associated with MBD2

Protein level used designations for MBD2