MBD2 antibody

Catalog No. ABIN6569193

Product Details anti-MBD2 Antibody

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human MBD2

Isotype: IgG

Application Details

Application Notes: WB 1:200 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2 (MBD2 Products)

Synonyms: MBD2 antibody, DMTase antibody, NY-CO-41 antibody, MBD2a antibody, wu:fa97f06 antibody, zgc:111862 antibody, methyl-CpG binding domain protein 2 antibody, methyl-CpG binding domain protein 2 S homeolog antibody, MBD2 antibody, Mbd2 antibody, mbd2 antibody, mbd2.S antibody

Background:

Synonyms: Demethylase,DMTase,MBD 2,Mbd2,MBD2,MBD2a,Methyl CpG binding domain protein 2,Methyl CpG binding protein MBD2,Methyl-CpG-binding domain protein 2,Methyl-CpG-binding protein MBD2,NY CO 41

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 53kDa

Calculated_MW: 31kDa/43kDa

Gene ID: 8932

UniProt: Q9UBB5

Pathways: Chromatin Binding