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CSB-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome.
a domesticated PiggyBac-like transposon PGBD3, residing within intron 5 of the CSB gene, functions as an alternative 3' terminal exon
This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Naturally-occurring readthrough transcription occurs between this gene and the adjacent ERCC6 gene (GeneID 2074), and results in a fusion protein that shares sequence with the product of each individual gene. The readthrough locus is represented by GeneID:101243544. There are several pseudogenes for this gene on chromosomes 4, 5 and 12.
piggyBac transposable element-derived protein 3
, piggyBac transposable element derived 3