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RAG2 Antigen Profile
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Alternative names and synonyms associated with RAG2
recombination activating 2 (RAG2) ELISA Kit
recombination activating gene 2 (RAG2) ELISA Kit
recombination activating gene 2 (Rag2) ELISA Kit
recombination activating 2 (Rag2) ELISA Kit
recombination activating gene 2 (rag2) ELISA Kit
recombination activating gene 2 S homeolog (rag2.S) ELISA Kit
RAG-2 ELISA Kit
Rag-2 ELISA Kit
rag-2 ELISA Kit
zgc:136743 ELISA Kit
Protein level used designations for RAG2
recombination activating gene 2
, recombination activating protein 2
, V(D)J recombination-activating protein 2-like
, V(D)J recombination-activating protein 2
, recombinase activating gene 2
, v(D)J recombination-activating protein 2