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We demonstrate that through this interaction, BBS6 (show MKKS ELISA Kits) modulates the sub-cellular localization of SMARCC1 and find, by transcriptional profiling, similar transcriptional changes following smarcc1a and bbs6 (show MKKS ELISA Kits) manipulation. Our work identifies a new function for BBS6 (show MKKS ELISA Kits) in nuclear-cytoplasmic transport, and provides insight into the disease mechanism underlying the congenital heart defects in McKusick-Kaufman syndrome (show MKKS ELISA Kits) patients.
Here, the authors first confirmed that SWIRM domain of BAF155 is responsible for its interaction with BAF47 and then narrowed down the SWIRM-binding region in BAF47 to the Repeat 1 (RPT1) domain.
NKX6.1 (show NKX6-1 ELISA Kits) directly enhances the mRNA level of E-cadherin (show CDH1 ELISA Kits) by recruiting BAF155 coactivator and represses that of vimentin (show VIM ELISA Kits) and N-cadherin (show CDH2 ELISA Kits) by recruiting RBBP7 (retinoblastoma binding protein 7 (show RBBP7 ELISA Kits)) corepressor.
Results show the secondary structure of SWIRM domain of BAF155 consists of five alpha-helices forming a typical histone fold for DNA interactions.
we identify BAF155 as a substrate for arginine methyltransferase CARM1 (show CARM1 ELISA Kits).
Wwp2 (show WWP2 ELISA Kits) acts as a ubiquitin ligase of SRG3.
miR (show MLXIP ELISA Kits)-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1.
loss of BAF155 expression represents another mechanism for inactivation of SWI (show SMARCA1 ELISA Kits)/SNF (show SNRPA ELISA Kits) complex activity in the development in human cancer.
Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12.
protein levels of BAF155/170 dictate the maximum cellular amount of BAF57
BAF155 and potentially INI1 (show SMARCB1 ELISA Kits) are substrates for Akt (show AKT1 ELISA Kits) phosphorylation
Conditional deletion of BAF155 causes impaired proliferation of olfactory neurons and defective axonogenesis in the developing olfactory epithelium.
BAF155 mediates the interaction between BAF (show BANF1 ELISA Kits) complexes and H3K27demethylases, controlling the global level of H3K27me2/3 and ultimately the gene expression program in cortical development.
the role of BAF155 in late pre-implantation stages of mouse embryos
Specific inactivation of Srg3 a core subunit of the remodeling complex, in developing limb buds hampered the transcriptional upregulation of Shh (show SHH ELISA Kits)/Gli (show GLI1 ELISA Kits) target genes, including the Shh (show SHH ELISA Kits) receptor Ptch1 (show PTCH1 ELISA Kits) and its downstream effector Gli1 (show GLI1 ELISA Kits) in the posterior limb bud
the increased frequency of Treg cells in the spinal cord of beta-actin (show ACTB ELISA Kits)-SRG3 Tg mice might induce the suppression of and accelerate the recovery from EAE symptoms.
Deletion of either Brg1 (show SMARCA4 ELISA Kits) in the subependymal zone (SEZ) causes the progeny of adult neural stem cells to convert to the ependymal lineage within the SEZ while migrating neuroblasts convert to different glial lineages en route to or in the olfactory bulb.
Characterization of a missense mutation allele of the Smarcc1 gene (Smarcc1msp3 or Baf155msp3); lends new insight into the functions of the BAF (show BANF1 ELISA Kits) chromatin remodeling complex during the critical stage of neural tube closure
Wwp2 (show WWP2 ELISA Kits) acts as a ubiquitin ligase (show RNF123 ELISA Kits) of SRG3.
Liver progenitor cells have intrinsic, cell proliferation-independent characteristics resulting in an increased reprogramming capacity compared to differentiated liver cells which requires the BAF (show BANF1 ELISA Kits) complex.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
, BRG1-associated factor 155
, SWI/SNF complex 155 kDa subunit
, SWI/SNF complex subunit SMARCC1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
, chromatin remodeling complex BAF155 subunit
, mammalian chromatin remodeling complex BRG1-associated factor 155
, SWI3-related protein