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YBX2 has the important role of coordinating the storage of translationally repressed mRNAs in round spermatids by inhibiting translational activity and the degradation of transcripts via translation-dependent deadenylation.
provides first evidence showing dbpC highly expressed in human testicular seminoma and ovarian dysgerminomas, and in carcinomas in other tissues and that its expression in normal tissues is nearly restricted to germ cells and placental trophoblasts
transcriptional regulation of Contrin was investigated, and the promoter region between -272 and -253 relative to the transcription start site was shown to be critical for the manifestation of cell-type specific transcription
A significant association between gene alterations in the YBX2 gene and abnormal spermatogenesis in humans, including a potential role in altering protamine expression, and implicate YBX2 gene alterations as a potential cause of male factor infertility.
some polymorphisms of the MSY2 gene might be associated with impaired spermatogenesis and that the gene could also be involved in modifying the susceptibility to idiopathic spermatogenic impairment in humans
Ybx2 is a novel regulator that controls brown adipose tissue activation by regulating mRNA stability.
mRNAs, possibly in a complex with MSY2 and PADI6, are bound in the cytoplasmic lattices (CPLs) and may play a role in securing the mRNA-MSY2 complex to the CPLs.
homozygous double mutants could not be generated as haploinsufficiency of both Ybx2 and Ybx3 (show CSDA Proteins) caused sterility characterized by extensive defects in spermatid differentiation.
data suggest that MSY2 packages mRNAs in vivo with relatively little sequence specificity, which may lead to both stabilization and translation repression of maternal mRNAs
binding of intact maternal mRNA by MSY2 is required for its cytoplasmic retention in oocytes
role for MSY2 in stabilizing maternal mRNAs in growing oocytes
MSY2 marks specific mRNAs in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay in meiotic and postmeiotic male germ cells of the mouse.
Results suggest that Msy2 represents one of a small number of germ-cell-specific genes whose deletion leads to the disruption of both spermatogenesis and oogenesis.
mRNA instability is a likely cause of the male infertility in Msy2-null mice.
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15.
Y box binding protein 2
, DNA-binding protein C
, MSY2 homolog
, Y-box-binding protein 2
, germ cell specific Y-box binding protein
, germ cell-specific Y-box-binding protein
, Y box protein 2
, FRGY2 homolog
, Y-box protein MSY2