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anti-Human C1R Antibodies:
anti-Rat (Rattus) C1R Antibodies:
anti-Mouse (Murine) C1R Antibodies:
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We identified a novel, homozygous, loss-of-function mutation (p.Pro445Leufs*11) in the C1R gene. Using the Sanger method of DNA sequencing in 14 family members, we confirmed the presence of the mutation in 4 patients with early-onset systemic lupus erythematosus and in an asymptomatic 9-year-old girl. Complement levels were low in sera from patients with truncated C1r protein.
Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S (show C1S Antibodies).
We confirmed increased levels of C1R and VTN (show VTN Antibodies) in sera from patients with Joint hypermobility syndrome by western blot analyses
C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s (show C1S Antibodies) proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin (show NCL Antibodies) and nucleophosmin 1 (show NPM1 Antibodies). T
C1r specificity is well suited to its cleavage targets and that efficient cleavage of C1s (show C1S Antibodies) is achieved through both active site and exosite contributions.
Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s (show C1S Antibodies)-C1r-C1r-C1s (show C1S Antibodies) tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 (show PTX3 Antibodies)
a structural rearrangement as a switch between functional states of human C1r
These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r and C1s (show C1S Antibodies).
The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity.
Detailed mapping of C1q post-translational modifications and insights into the C1r/C1s (show C1S Antibodies) binding sites.
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
complement C1r subcomponent
, complement C1r
, complement component 1, r subcomponent
, complement component 1 subcomponent r