C1R antibody (AA 466-705)

Catalog No. ABIN6137761

Product Details anti-C1R Antibody

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Binding Specificity: AA 466-705

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1R antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: GGQKAKMGNF PWQVFTNIHG RGGGALLGDR WILTAAHTLY PKEHEAQSNA SLDVFLGHTN VEELMKLGNH PIRRVSVHPD YRQDESYNFE GDIALLELEN SVTLGPNLLP ICLPDNDTFY DLGLMGYVSG FGVMEEKIAH DLRFVRLPVA NPQACENWLR GKNRMDVFSQ NMFCAGHPSL KQDACQGDSG GVFAVRDPNT DRWVATGIVS WGIGCSRGYG FYTKVLNYVD WIKKEMEEED

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C1R

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Alternative Name: C1R (C1R Products)

Synonyms: C1R antibody, MGC84776 antibody, MGC127774 antibody, c1rl antibody, complement C1r antibody, complement component 1, r subcomponent L homeolog antibody, complement component 1, r subcomponent antibody, C1R antibody, C1r antibody, c1r.L antibody, c1r antibody

Background: The classical complement pathway plays a major role in innate immunity against infection. This pathway is triggered by C1, a multimolecular complex composed of the recognition protein C1q and two serine proteases, C1r and C1s. Following the C1q recognition, C1r is autoactivated, and in turn activates C1s, which cleaves C4 and C2, the C1 substrates. C1r acts by transforming the activation signal into an enzymic activity. C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation. This protien recognizes full-length C1r chain and the cleaved B chain.,C1R,EDSPD1,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,C1R

Molecular Weight: 80 kDa

Gene ID: 715

UniProt: P00736

Pathways: Complement System