C4BPB Proteins

Protein Summary

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

Alternative names and synonyms associated with C4BPB

• complement component 4 binding protein beta (C4BPB) antibody
• complement component 4 binding protein, beta (C4bpb) antibody

• C4BP antibody
• C4bp-ps1 antibody
• C4BPB antibody

Protein level used designations for C4BPB

complement component 4 binding protein, beta , complement component 4 binding protein, beta chain , C4b-binding protein beta chain , complement component 4-binding protein, beta