Browse our C8A Proteins (C8A)

Full name:: Complement Component 8, alpha Polypeptide Proteins (C8A)

On www.antibodies-online.com are 4 Complement Component 8, alpha Polypeptide (C8A) Proteins from 2 different suppliers available. Additionally we are shipping C8A Kits (8) and C8A Antibodies (8) and many more products for this protein. A total of 20 C8A products are currently listed.

Synonyms:

list all proteins	Gene Name	GeneID	UniProt
	C8A	731	P07357
	C8A	230558	Q8K182
	C8A
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Relevant Pathways for C8A Proteins

Complement System

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Human Complement Component 8, alpha Polypeptide (C8A) interaction partners

C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
The binding specificity between C8 alpha and C8 beta subunits is determined by a cooperative interaction of the N-terminal thrombospondin type 1 module and the membrane attack complex/perforin (show PRF1 Proteins) domain.
Both N-terminal modules in C8 alpha have a role in forming the principal binding site for C9, and binding may be dependent on a cooperative interaction between these modules and the C8 alpha membrane attack complex/perforin (show PRF1 Proteins) domain.
result suggests that this segment of C8alpha and corresponding segments of the other MAC family members are independently folded domains

C8A Protein Profile

Protein Summary

C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency.

Alternative names and synonyms associated with C8A

complement C8 alpha chain (C8A)
complement component 8, alpha polypeptide (C8a)

Protein level used designations for C8A

complement component 8 subunit alpha , complement component C8 alpha chain , complement component 8 alpha subunit , complement component C8 alpha subunit

GENE ID	SPECIES
731	Homo sapiens
230558	Mus musculus
100009076	Oryctolagus cuniculus

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