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Browse our anti-Complement Factor I (CFI) Antibodies

Full name:: anti-Complement Factor I Antibodies (CFI)

On www.antibodies-online.com are 130 Complement Factor I (CFI) Antibodies from 22 different suppliers available. Additionally we are shipping Complement Factor I Kits (25) and Complement Factor I Proteins (15) and many more products for this protein. A total of 174 Complement Factor I products are currently listed.

Synonyms:: AHUS3, C3b-INA, c3bc4bi, C3BINA, CFI, factor I, FI, gb:ai721528, IF, KAF, MGC53615

list all antibodies	Gene Name	GeneID	UniProt
	CFI	12630	Q61129
	CFI	3426	P05156
	CFI	79126	Q9WUW3
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Most Popular Reactivities for anti-Complement Factor I (CFI) Antibodies

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anti-Mouse (Murine) Complement Factor I Antibodies:

10 WB Antibodies

anti-Human Complement Factor I Antibodies:

anti-Rat (Rattus) Complement Factor I Antibodies:

6 WB Antibodies

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Relevant Pathways for anti-Complement Factor I Antibodies

Complement System

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Top referenced anti-Complement Factor I Antibodies

Human Monoclonal Complement Factor I Primary Antibody for Func, IHC (fro) - ABIN2473071 : Ernberg: Studies on Epstein-Barr virus-associated antigens. in Annals of the New York Academy of Sciences 1975 (PubMed)
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More Antibodies against Complement Factor I Interaction Partners

Mouse (Murine) Complement Factor I (CFI) interaction partners

Factor I-mediated generation of activated C3 fragments in the circulation is a critical determinant for the development of MPGN2 associated with factor H deficiency.

Human Complement Factor I (CFI) interaction partners

performed sequence analysis of the complement genes complement factor H (CFH), complement factor I (CFI), and complement C3 (C3) in 866 aHUS/C3G and 697 AMD patients. In total, we identified 505 low-frequency alleles, representing 121 unique variants, of which 51 are novel
Oxidized CFH enhances Factor I mediated cleavage of C3 and C3b whereas the reduced form loses this activity in age-related macular degeneration.
CFI deficiency is thus now added to the growing list of monogenic causes of vasculitis and should always be considered in vasculitis patients found to have persistently low levels of C3 with normal C4.
A high occurrence of Ile357Met mutation and association of simultaneous genetic abnormalities of CFI characterized our Tunisian Atypical Hemolytic and Uremic syndrome patients.
CFI rs141853578 (G119R) is a risk factor for developing advanced type AMD. This study also suggests that the frequency of G119R polymorphism in our population is not as rare as reported from other populations.
This study has revealed a significant genetic role for CFI-rs13104777 in acute anterior uveitis. This influence may be dependent on human leukocyte antigen (HLA)-B27 and disease laterality.
An extremely rare, heterozygous mutation in the gene encoding CFI likely affecting splicing was associated for the first time with atypical hemolytic uremic syndrome.
this study illustrates the importance of early versus late diagnosis of CFI deficiency
This finding although rare does suggest that screening for chromosomal rearrangements affecting CFI should be undertaken in all aHUS patients particularly if the factor I level is unexplainably low.
Factor I binds C3b-Factor H between Factor H domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.
Taken together, our data argue that multiple rare and ultra-rare alleles in CFI contribute to AMD pathogenesis; they improve the precision of the assessment of the contribution of CFI to AMD
Case Report: thrombotic microangiopathy with mutations in complement factor I and thrombomodulin.
Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome.
Patients with advanced atrophic AMD carried these rare variants more frequently than patients with neovascular AMD (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04).
Low FI levels are strongly associated with rare CFI variants and age-related macular degeneration.
A missense variant (p.V412M) in CFI was discovered in two Tunisian Jewish families with early-onset age-related macular degeneration.
Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies.
In this study, the odds of AMD were highest in those with deficient vitamin D status and 2 risk alleles for the CFH and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function.
iC3b level, a proteolytically inactive form of C3b, was lower in HCV infected patient sera, reflecting impairment of both C3 convertase and Factor I activity.
association between rs10033900 and age-related macular degeneration risk in Han Chinese population

Complement Factor I (CFI) Antigen Profile

Antigen Summary

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

complement factor I S homeolog (cfi.S) antibody
complement factor I L homeolog (cfi.L) antibody
complement factor I (CFI) antibody
complement factor I (cfi) antibody
complement component factor i (Cfi) antibody
complement factor I (Cfi) antibody

AHUS3 antibody
C3b-INA antibody
c3bc4bi antibody
C3BINA antibody
CFI antibody
factor I antibody
FI antibody
gb:ai721528 antibody
IF antibody
KAF antibody
MGC53615 antibody

Protein level used designations for CFI

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1

GENE ID	SPECIES
379108	Xenopus laevis
399318	Xenopus laevis
471271	Pan troglodytes
557557	Danio rerio
613100	Xenopus (Silurana) tropicalis
100072852	Equus caballus
100306949	Ictalurus punctatus
12630	Mus musculus
3426	Homo sapiens
79126	Rattus norvegicus
100338923	Oryctolagus cuniculus
100713918	Cavia porcellus
513197	Bos taurus
478515	Canis lupus familiaris
428773	Gallus gallus
101119307	Ovis aries
100174703	Pongo abelii
100516921	Sus scrofa

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Show all anti-Complement Factor I (CFI) Antibodies with Pubmed References

Mouse (Murine) Complement Factor I (CFI) interaction partners

Human Complement Factor I (CFI) interaction partners

Antigen Summary

Alternative names and synonyms associated with Complement Factor I (CFI)

Protein level used designations for CFI