anti-Complement Factor I Antibodies

Protein Summary

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

• complement factor I S homeolog (cfi.S) antibody
• complement factor I L homeolog (cfi.L) antibody
• complement factor I (CFI) antibody
• complement factor I (cfi) antibody
• complement component factor i (Cfi) antibody
• Show all gene names
• complement factor I (Cfi) antibody

• AHUS3 antibody
• C3b-INA antibody
• c3bc4bi antibody
• C3BINA antibody
• CFI antibody
• Show all synonym aliases
• factor I antibody
• FI antibody
• gb:ai721528 antibody
• IF antibody
• KAF antibody
• MGC53615 antibody

Protein level used designations for CFI

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1