Browse our anti-Complement Factor I (CFI) Antibodies

Full name:: anti-Complement Factor I Antibodies (CFI)

On www.antibodies-online.com are 163 Complement Factor I (CFI) Antibodies from 0 different suppliers available. A total of 235 Complement Factor I products are currently listed.

Synonyms:: AHUS3, C3b-INA, c3bc4bi, C3BINA, CFI, factor I, FI, gb:ai721528, IF, KAF, MGC53615

list all antibodies	Gene Name	GeneID	UniProt
Anti-Mouse CFI	CFI	12630	Q61129
Anti-Human CFI	CFI	3426	P05156
Anti-Rat CFI	CFI	79126	Q9WUW3
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Relevant Pathways for anti-Complement Factor I Antibodies

Complement System

More product categories related to Complement Factor I Antibody

Top referenced anti-Complement Factor I Antibodies

Human Monoclonal Complement Factor I Primary Antibody for FACS, IHC (p) - ABIN315441 : Crook, Hunt: Enrichment of early fetal-liver hemopoietic stem cells of the rat using monoclonal antibodies against the transferrin receptor, Thy-1, and MRC-OX82. in Developmental immunology 1996 (PubMed)
Human Monoclonal Complement Factor I Primary Antibody for IP, RIA - ABIN2473072 : Hsiung, Barclay, Brandon, Sim, Porter: Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. in The Biochemical journal 1982 (PubMed)
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Human Monoclonal Complement Factor I Primary Antibody for Func, IHC (fro) - ABIN2473071 : Ernberg: Studies on Epstein-Barr virus-associated antigens. in Annals of the New York Academy of Sciences 1975 (PubMed)
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More Antibodies against Complement Factor I Interaction Partners

Mouse (Murine) Complement Factor I (CFI) interaction partners

Factor I-mediated generation of activated C3 fragments in the circulation is a critical determinant for the development of MPGN2 associated with factor H (show CFH Antibodies) deficiency.

Human Complement Factor I (CFI) interaction partners

this study illustrates the importance of early versus late diagnosis of CFI deficiency
This finding although rare does suggest that screening for chromosomal rearrangements affecting CFI should be undertaken in all aHUS patients particularly if the factor I level is unexplainably low.
Factor I binds C3b-Factor H (show CFH Antibodies) between Factor H (show CFH Antibodies) domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.
Taken together, our data argue that multiple rare and ultra-rare alleles in CFI contribute to AMD (show AMD1 Antibodies) pathogenesis; they improve the precision of the assessment of the contribution of CFI to AMD (show AMD1 Antibodies)
Case Report: thrombotic microangiopathy with mutations in complement factor I and thrombomodulin (show THBD Antibodies).
Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome.
Patients with advanced atrophic AMD (show AMD1 Antibodies) carried these rare variants more frequently than patients with neovascular AMD (show AMD1 Antibodies) (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04).
Low FI levels are strongly associated with rare CFI variants and age-related macular degeneration.
A missense variant (p.V412M) in CFI was discovered in two Tunisian Jewish families with early-onset age-related macular degeneration.
Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H (show CFH Antibodies) and factor I, are not packaged in Weibel-Palade bodies.

Complement Factor I (CFI) Antigen Profile

Antigen Summary

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

complement factor I S homeolog (cfi.S) antibody
complement factor I L homeolog (cfi.L) antibody
complement factor I (CFI) antibody
complement factor I (cfi) antibody
complement component factor i (Cfi) antibody
complement factor I (Cfi) antibody

AHUS3 antibody
C3b-INA antibody
c3bc4bi antibody
C3BINA antibody
CFI antibody
factor I antibody
FI antibody
gb:ai721528 antibody
IF antibody
KAF antibody
MGC53615 antibody

Protein level used designations for CFI

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1

GENE ID	SPECIES
379108	Xenopus laevis
399318	Xenopus laevis
471271	Pan troglodytes
557557	Danio rerio
613100	Xenopus (Silurana) tropicalis
100072852	Equus caballus
100306949	Ictalurus punctatus
12630	Mus musculus
3426	Homo sapiens
79126	Rattus norvegicus
100338923	Oryctolagus cuniculus
100713918	Cavia porcellus
513197	Bos taurus
478515	Canis lupus familiaris
428773	Gallus gallus
101119307	Ovis aries
100174703	Pongo abelii
100516921	Sus scrofa

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Show all anti-Complement Factor I (CFI) Antibodies with Pubmed References

Mouse (Murine) Complement Factor I (CFI) interaction partners

Human Complement Factor I (CFI) interaction partners

Antigen Summary

Alternative names and synonyms associated with Complement Factor I (CFI)

Protein level used designations for CFI