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|Antigen||Kallikrein 1 (KLK1) Antibodies|
|Epitope||AA 243-261, C-Term Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This Kallikrein 1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
Product Details anti-Kallikrein 1 AntibodyTarget Details Kallikrein 1 Application Details Handling References for anti-Kallikrein 1 antibody (ABIN3043080) Images
|Purpose||Rabbit IgG polyclonal antibody for Kallikrein-1(KLK1) detection. Tested with WB, IHC-P in Mouse.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Kallikrein-1(KLK1) detection. Tested with WB, IHC-P in Mouse.
Gene Name: kallikrein 1
Protein Name: Kallikrein-1
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 1(243-261aa YTRVLNFNTWIRETMAEND).|
|Plasmids, Primers & others|
Target Details Kallikrein 1Product Details anti-Kallikrein 1 Antibody Application Details Handling References for anti-Kallikrein 1 antibody (ABIN3043080) Images back to top
|Alternative Name||KLK1 (KLK1 Antibody Abstract)|
KLK1(KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Synonyms: Glandular kallikrein 1 antibody|hK 1 antibody|hK1 antibody|Kallikrein serine protease 1 antibody|Kallikrein-1 antibody|Kidney/pancreas/salivary gland kallikrein antibody|Klk 6 antibody|KLK1 antibody|KLK1_HUMAN antibody|Klk6 antibody|KLKR antibody|Tissue kallikrein antibody
Application DetailsProduct Details anti-Kallikrein 1 Antibody Target Details Kallikrein 1 Handling References for anti-Kallikrein 1 antibody (ABIN3043080) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
|Restrictions||For Research Use only|
HandlingProduct Details anti-Kallikrein 1 Antibody Target Details Kallikrein 1 Application Details References for anti-Kallikrein 1 antibody (ABIN3043080) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-Kallikrein 1 antibody (ABIN3043080)Product Details anti-Kallikrein 1 Antibody Target Details Kallikrein 1 Application Details Handling Images back to top
|Product cited in:||
Zhang, Xu, Zhao, Chen: "Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury." in: Oncotarget, Vol. 8, Issue 37, pp. 61385-61392, 2017
Lin, Lin, Chung, Vonderfecht, Camden, Flodby, Borok, Limesand, Mizushima, Ann: "Dynamic involvement of ATG5 in cellular stress responses." in: Cell death & disease, Vol. 5, pp. e1478, 2014
ImagesProduct Details anti-Kallikrein 1 Antibody Target Details Kallikrein 1 Application Details Handling References for anti-Kallikrein 1 antibody (ABIN3043080) back to top